22 Result(s)
within
**ghui Wei
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessRegio- and stereoselective access to highly substituted vinylphosphine oxides via metal-free electrophilic phosphonoiodination of alkynes
In general, the P-centered ring-opening of quaternary phosphirenium salts (QPrS) predominantly leads to hydrophosphorylated products, while the C-centered ring-opening is primarily confined to intramolecular n...
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Article
Open AccessDevelopment of deaminase-free T-to-S base editor and C-to-G base editor by engineered human uracil DNA glycosylase
DNA base editors enable direct editing of adenine (A), cytosine (C), or guanine (G), but there is no base editor for direct thymine (T) editing currently. Here we develop two deaminase-free glycosylase-based b...
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Article
Open AccessCatalytic asymmetric synthesis of planar-chiral dianthranilides via (Dynamic) kinetic resolution
Chirality constitutes an inherent attribute of nature. The catalytic asymmetric synthesis of molecules with central, axial, and helical chirality is a topic of intense interest and is becoming a mature field o...
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Article
Open AccessUmpolung reactivity of strained C–C σ-bonds without transition-metal catalysis
Umpolung is an old and important concept in organic chemistry, which significantly expands the chemical space and provides unique structures. While, previous research focused on carbonyls or imine derivatives,...
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Open AccessComparison of different machine learning classification models for predicting deep vein thrombosis in lower extremity fractures
Deep vein thrombosis (DVT) is a common complication in patients with lower extremity fractures. Once it occurs, it will seriously affect the quality of life and postoperative recovery of patients. Therefore, e...
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Article
Open AccessImpact of vaccination on the association of COVID-19 with cardiovascular diseases: An OpenSAFELY cohort study
Infection with SARS-CoV-2 is associated with an increased risk of arterial and venous thrombotic events, but the implications of vaccination for this increased risk are uncertain. With the approval of NHS Engl...
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Open AccessA Mendelian randomization study on the causal relationship between smoking, alcohol consumption, and the development of myopia and astigmatism
The influence of environmental factors like smoking and alcohol on myopia and astigmatism is controversial. However, due to ethical concerns, alternative study designs are urgently needed to assess causal infe...
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Research on Energy Transport Characteristics of an Axial Flow Circulating Pump under Unpowered Driven and Pump Operating Conditions
An axial flow circulating pump (AFCP), as a key facility of the large vessel power system, is designed for conveying cooling water of the power system. The pump will be rotated actively under the drive of moto...
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Open AccessCatalytic asymmetric dearomatization of phenols via divergent intermolecular (3 + 2) and alkylation reactions
The catalytic asymmetric dearomatization (CADA) reaction has proved to be a powerful protocol for rapid assembly of valuable three-dimensional cyclic compounds from readily available planar aromatics. In contr...
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Article
Open AccessEngineered CRISPR-OsCas12f1 and RhCas12f1 with robust activities and expanded target range for genome editing
The type V-F CRISPR-Cas12f system is a strong candidate for therapeutic applications due to the compact size of the Cas12f proteins. In this work, we identify six uncharacterized Cas12f1 proteins with nuclease...
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Open AccessExperimental study on the shear performance of an anchor cable with a C-shaped tube anchored flat structural plane
To analyse the influence of normal stress (σn) and steel tube strength on an anchor cable with a C-shaped tube (ACC), we selected Q235 steel tubes and Q345 steel tubes as representative ACCs and carried out doubl...
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Open AccessAnalysis of clinical presentations, lip transepidermal water loss and associated dermatological conditions in patients with chronic cheilitis
Chronic cheilitis (CC) is a spectrum of inflammatory changes of unknown etiology that affect the vermilion of the lips. This study aimed to describe the epidemiology, clinical presentations and risk factors of...
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Article
Open AccessForecasts for the concentration of petroleum gas leakage diffusion under different liquid level heights of a sealing ring of sizeable floating roof tank
The sealing ring of the external floating roof tank is prone to petroleum gas leakage due to material aging and oil corrosion. Petroleum gas leakage and diffusion easily accumulate above the floating deck. Whe...
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Article
Open AccessDesymmetrization of N-Cbz glutarimides through N-heterocyclic carbene organocatalysis
Over the past decade, the catalysis of N-heterocyclic carbenes has achieved significant advances. In this area, aldehydes, enals, and esters, are commonly employed as starting materials through various catalytic ...
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Article
Open AccessSource analysis of heavy metal pollution in agricultural soil irrigated with sewage in Wuqing, Tian**
In this study, the contents of heavy metals and Cd and Pb isotope ratios of agricultural soil and potential source samples collected from farmland receiving sewage irrigation in Wuqing District, Tian**, China...
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Article
Open AccessOrganocatalytic asymmetric N-sulfonyl amide C-N bond activation to access axially chiral biaryl amino acids
Amides are among the most fundamental functional groups and essential structural units, widely used in chemistry, biochemistry and material science. Amide synthesis and transformations is a topic of continuous...
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Article
Open AccessHydrological simulation and uncertainty analysis using the improved TOPMODEL in the arid Manas River basin, China
Understanding the mechanism of complicated hydrological processes is important for sustainable management of water resources in an arid area. This paper carried out the simulations of water movement for the Ma...
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Open AccessModeling and prediction of copper removal from aqueous solutions by nZVI/rGO magnetic nanocomposites using ANN-GA and ANN-PSO
Reduced graphene oxide-supported nanoscale zero-valent iron (nZVI/rGO) magnetic nanocomposites were prepared and then applied in the Cu(II) removal from aqueous solutions. Scanning electron microscopy, transmi...
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Open AccessStudy on the characteristics of future precipitation in response to external changes over arid and humid basins
The simulation abilities of the Coupled Model Inter-comparison Project Phase 5 (CMIP5) models to the arid basin (the Tarim River Basin, TRB) and humid basin (the Yangtze River Basin, YRB) were evaluated, deter...
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Article
Open AccessBaculovirus infection induces disruption of the nuclear lamina
Baculovirus nucleocapsids egress from the nucleus primarily via budding at the nuclear membrane. The nuclear lamina underlying the nuclear membrane represents a substantial barrier to nuclear egress. Whether t...
