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  1. Article

    Open Access

    Age-related visual impairments and retinal ganglion cells axonal degeneration in a mouse model harboring OPTN (E50K) mutation

    Retinal ganglion cells (RGCs) axons are the signal carriers of visual information between retina and brain. Therefore, they play one of the important roles affected in many optic neurodegenerative diseases lik...

    Mingying Hou, Zhengbo Shao, Shiqi Zhang, **nna Liu, Pan Fan… in Cell Death & Disease (2022)

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  2. Article

    Open Access

    Neuroprotective effects of bone marrow Sca-1+ cells against age-related retinal degeneration in OPTN E50K mice

    Glaucoma is characterized by retinal ganglion cell (RGC) death, the underlying mechanisms of which are still largely unknown. An E50K mutation in the Optineurin (OPTN) gene is a leading cause of normal-tension...

    **nna Liu, Mingying Hou, Shiqi Zhang, Yutong Zhao, Qi Wang… in Cell Death & Disease (2021)

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  3. Article

    Open Access

    The E50K optineurin mutation impacts autophagy-mediated degradation of TDP-43 and leads to RGC apoptosis in vivo and in vitro

    The glaucoma-associated E50K mutation in optineurin (OPTN) is known to affect autophagy and cause the apoptosis of retinal ganglion cells (RGCs), but the pathogenic mechanism remains unclear. In this study, we...

    Shiqi Zhang, Zhengbo Shao, **nna Liu, Mingying Hou, Fang Cheng… in Cell Death Discovery (2021)

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  4. No Access

    Article

    Novel resistance mechanism of barley chlorina f104 antenna mutant against photoinhibition: possible role of new identified chloroplastic cpNrp protein

    Protein with NmrA domain serving as the receptor for oxidized NAD+/NADP was identified in chloroplasts of spring barley mutant chlorina f104. NmrA was upregulated under environmental stresses in comparison to wil...

    Marián Brestič, Marek Živčák, Miroslav Ďatko… in Theoretical and Experimental Plant Physiol… (2015)