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  1. No Access

    Article

    PXR mediates mifepristone-induced hepatomegaly in mice

    Mifepristone (Mif), an effective synthetic steroidal antiprogesterone drug, is widely used for medical abortion and pregnancy prevention. Due to its anti-glucocorticoid effect, high-dose Mif is also used to tr...

    **n-peng Yao, Ting-ying Jiao, Yi-ming Jiang, Shi-cheng Fan… in Acta Pharmacologica Sinica (2022)

  2. Article

    Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein

    An epidemic of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading worldwide. SARS-CoV-2 relies on its spike protein to invade host cells by interacting with the human...

    Lin Wang, Yan Wu, Sheng Yao, Huan Ge, Ya Zhu, Kun Chen… in Acta Pharmacologica Sinica (2022)

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    Article

    Deubiquitinating enzyme USP11 promotes renal tubular cell senescence and fibrosis via inhibiting the ubiquitin degradation of TGF-β receptor II

    Transforming growth factor-β1 (TGF-β1) is regarded as a key factor in promoting renal fibrosis during chronic kidney disease (CKD). Signaling transduction of TGF-β1 starts with binding to TGF-β type II recepto...

    Jia-yun Ni, **n Wang, Hong-yan **e, Ning-hao Yang… in Acta Pharmacologica Sinica (2023)

  4. No Access

    Article

    PGAM5 exacerbates acute renal injury by initiating mitochondria-dependent apoptosis by facilitating mitochondrial cytochrome c release

    Acute kidney injury (AKI) is a worldwide public health problem characterized by the massive loss of tubular cells. However, the precise mechanism for initiating tubular cell death has not been fully elucidated...

    **g-yao Li, **-ang Sun, **n Wang, Ning-hao Yang… in Acta Pharmacologica Sinica (2024)

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    Article

    E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1

    The circadian clock is the inner rhythm of life activities and is controlled by a self-sustained and endogenous molecular clock, which maintains a ~ 24 h internal oscillation. As the core element of the circad...

    Chun-yan Duan, Yue Li, Hao-yu Zhi, Yao Tian, Zheng-yun Huang… in Acta Pharmacologica Sinica (2024)

  6. No Access

    Article

    Human amniotic epithelial stem cell is a cell therapy candidate for preventing acute graft-versus-host disease

    Graft-versus-host disease (GVHD), an immunological disorder that arises from donor T cell activation through recognition of host alloantigens, is the major limitation in the application of allogeneic hematopoi...

    Peng-jie Yang, **ang-yu Zhao, Yao-hui Kou, Jia Liu… in Acta Pharmacologica Sinica (2024)

  7. Article

    Publisher Correction: E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1

    Chun-yan Duan, Yue Li, Hao-yu Zhi, Yao Tian, Zheng-yun Huang… in Acta Pharmacologica Sinica (2024)

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