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Article
Open AccessTumor promoting effect of PDLIM2 downregulation involves mitochondrial ROS, oncometabolite accumulations and HIF-1α activation
Cancer is characterized by dysregulated cellular metabolism. Thus, understanding the mechanisms underlying these metabolic alterations is important for develo** targeted therapies. In this study, we investig...
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Article
Open AccessCerebrospinal fluid shunt surgery reduces the risk of develo** dementia and Alzheimer’s disease in patients with idiopathic normal pressure hydrocephalus: a nationwide population-based propensity-weighted cohort study
Patients with idiopathic normal-pressure hydrocephalus (iNPH) are predisposed to develo** dementing disorders. Cerebrospinal fluid (CSF) shunt implantation is a treatment used to improve the motor and cognit...
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Article
Oriented lateral growth of two-dimensional materials on c-plane sapphire
Two-dimensional (2D) semiconducting transition metal dichalcogenides (TMDs) represent the ultimate thickness for scaling down channel materials. They provide a tantalizing solution to push the limit of semicon...
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Article
Open AccessLong read isoform sequencing reveals hidden transcriptional complexity between cattle subspecies
The Iso-Seq method of full-length cDNA sequencing is suitable to quantify differentially expressed genes (DEGs), transcripts (DETs) and transcript usage (DTU). However, the higher cost of Iso-Seq relative to R...
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Article
Open AccessA robust embedded load cell sensor for tool life prognosis and smart sawing of medium carbon steel
An embedded load cell sensor is proposed for the tool life prognosis and thrust force control of a band saw machine. The sensor enables the tool life and surface quality of the machined workpiece to be effecti...
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Article
Open AccessChanging surface ocean circulation caused the local demise of echinoid Scaphechinus mirabilis in Taiwan during the Pleistocene–Holocene transition
Abundant fossil specimens of Scaphechinus mirabilis, now occurring mostly in temperate waters, have been found in the Toukoshan Formation (Pleistocene) in Miaoli County, Taiwan. Environmental changes leading to i...
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Article
Open AccessRising incidence of HPV positive oropharyngeal cancer in Taiwan between 1999 and 2014 where betel nut chewing is common
The incidence of human papillomavirus (HPV) positive oropharyngeal cancer (OPC) is rising but HPV negative OPC is decreasing in Western countries. In Taiwan, the incidence of HPV negative OPC is common but the...
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Article
Open AccessMeasuring Heterogeneity in 18F-Fluorodeoxyglucose Positron Emission Tomography Images for Classifying Metastatic and Benign Bone Lesions in Patients with Cervical Cancer
Heterogeneity assessment can be applied for medical imaging analysis. Here, we evaluated first-order and texture analysis (TA) metrics in 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) imagin...
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Article
Open AccessHuman ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation
Human ribonuclease 1 (hRNase 1) is critical to extracellular RNA clearance and innate immunity to achieve homeostasis and host defense; however, whether it plays a role in cancer remains elusive. Here, we demo...
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Article
Pten-NOLC1 fusion promotes cancers involving MET and EGFR signalings
Inactivation of Pten gene through deletions and mutations leading to excessive pro-growth signaling pathway activations frequently occurs in cancers. Here, we report a Pten derived pro-cancer growth gene fusion P...
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Article
Open AccessMeasurement of long-range two-particle azimuthal correlations in Z-boson tagged pp collisions at \(\sqrt{s}=8\) and 13 TeV
Results are presented from the measurement by ATLAS of long-range (\(|\Delta \eta |>2\)|Δη|>2) dihadron angular correlations in \(\sqrt{s}=8\)s=8 and 13 TeV pp collisions containing a Z boson. The analysis is per...
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Article
Open AccessFluctuations of anisotropic flow in Pb+Pb collisions at \( \sqrt{{\mathrm{s}}_{\mathrm{NN}}} \) = 5.02 TeV with the ATLAS detector
Multi-particle azimuthal cumulants are measured as a function of centrality and transverse momentum using 470 μb−1 of Pb+Pb collisions at sNN\( \sqrt{s_{\mathrm{NN}}} \) = 5.02 TeV with the ATLAS detector at the ...
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Article
Open AccessA Smartphone-based Diffusometric Immunoassay for Detecting C-Reactive Protein
In this study, we developed a portable smartphone-based diffusometry for analyzing the C-reactive protein (CRP) concentration. An optimized fluorescence microscopic add-on system for a smartphone was used to i...
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Article
Open AccessNaturally occurring mutations in PB1 affect influenza A virus replication fidelity, virulence, and adaptability
Mutations in the PB1 subunit of RNA-dependent RNA polymerase (RdRp) of influenza A virus can affect replication fidelity. Before the influenza A/H1N1 pandemic in 2009, most human influenza A/H1N1 viruses conta...
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Article
Open AccessPotential usefulness of 68Ga-citrate PET/CT in detecting infected lower limb prostheses
Prosthetic joint infections may lead to failures of total joint arthroplasty. Radionuclide imaging can play a diagnostic role in identifying such infections, which require two-stage exchange arthroplasty (inst...
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Chapter and Conference Paper
The Impact of Game-Based Situated Learning System in Oral Health Education
This study aimed to determine the effectiveness of a game-based situated learning system in oral health education, on middle age and elderly subjects. The learning outcomes of the middle-aged and elderly subje...
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Article
Open AccessMeasurement of the azimuthal anisotropy of charged particles produced in \(\sqrt{s_{_\text {NN}}}\) = 5.02 TeV Pb+Pb collisions with the ATLAS detector
Measurements of the azimuthal anisotropy in lead–lead collisions at \(\sqrt{s_{_\text {NN}}}\)
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Article
Open AccessMeasurements of b-jet tagging efficiency with the ATLAS detector using \( t\overline{t} \) events at \( \sqrt{s}=13 \) TeV
The efficiency to identify jets containing b-hadrons (b-jets) is measured using a high purity sample of dileptonic top quark-antiquark pairs (
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Article
Open AccessSearch for pair production of heavy vector-like quarks decaying into high-pT W bosons and top quarks in the lepton-plus-jets final state in pp collisions at \( \sqrt{s}=13 \) TeV with the ATLAS detector
A search is presented for the pair production of heavy vector-like B quarks, primarily targeting B quark decays into a W boson and a top quark. The search is based on 36.1 fb−1 of pp collisions at ...
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Article
Open AccessSubmarine Groundwater Discharge helps making nearshore waters heterotrophic
Submarine groundwater discharge (SGD) is the submarine seepage of all fluids from coastal sediments into the overlying coastal seas. It has been well documented that the SGD may contribute a great deal of allo...
