39 Result(s)

Article

Dynamic changes in RNA m⁶A and 5 hmC influence gene expression programs during macrophage differentiation and polarisation

RNA modifications are essential for the establishment of cellular identity. Although increasing evidence indicates that RNA modifications regulate the innate immune response, their role in monocyte-to-macropha...

Natalia Pinello, Renhua Song, Quintin Lee… in Cellular and Molecular Life Sciences (2024)

Article

Transcription factor ATMIN facilitates chemoresistance in nasopharyngeal carcinoma

Despite that the docectaxel-cisplatin-5-fluorouracil (TPF) induction chemotherapy has greatly improved patients’ survival and became the first-line treatment for advanced nasopharyngeal carcinoma (NPC), not al...

Xue-Liang Fang, Qing-Jie Li, Jia-Yi Lin, Cheng-Long Huang… in Cell Death & Disease (2024)

Article

Pan-cancer surveys indicate cell cycle-related roles of primate-specific genes in tumors and embryonic cerebrum

Despite having been extensively studied, it remains largely unclear why humans bear a particularly high risk of cancer. The antagonistic pleiotropy hypothesis predicts that primate-specific genes (PSGs) tend t...

Chenyu Ma, Chunyan Li, Hui**g Ma, Daqi Yu, Yufei Zhang, Dan Zhang… in Genome Biology (2022)

Article

Fungal diversity notes 1512–1610: taxonomic and phylogenetic contributions on genera and species of fungal taxa

This article is the 14th in the Fungal Diversity Notes series, wherein we report 98 taxa distributed in two phyla, seven classes, 26 orders and 50 families which are described and illustrated. Taxa in this stu...

Ruvishika S. Jayawardena, Kevin D. Hyde, Song Wang, Ya-Ru Sun… in Fungal Diversity (2022)

Article

DNA damage-induced paraspeckle formation enhances DNA repair and tumor radioresistance by recruiting ribosomal protein P0

Paraspeckles are mammal-specific membraneless nuclear bodies that participate in various biological processes. NONO, a central paraspeckle component, has been shown to play pivotal roles in DNA double-strand b...

Yun-Long Wang, Wan-Wen Zhao, Shao-Mei Bai, Yan Ma, **n-Ke Yin… in Cell Death & Disease (2022)

Article

m6A methylation mediates LHPP acetylation as a tumour aerobic glycolysis suppressor to improve the prognosis of gastric cancer

LHPP, a histidine phosphatase, has been implicated in tumour progression. However, its role, underlying mechanisms, and prognostic significance in human gastric cancer (GC) are elusive. Here, we obtained GC ti...

Jian-**an Lin, Ning-Zi Lian, You-**n Gao, Qiao-Ling Zheng… in Cell Death & Disease (2022)

Article

Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is an aggressive malignancy with extremely skewed ethnic and geographic distributions. Increasing evidence indicates that targeting the tumor microenvironment (TME) represents a ...

Yu-Pei Chen, Jian-Hua Yin, Wen-Fei Li, Han-Jie Li, Dong-** Chen… in Cell Research (2020)

Article

Cdc42 subcellular relocation in response to VEGF/NRP1 engagement is associated with the poor prognosis of colorectal cancer

Microscopic indications of malignancy and hallmark molecules of cancer are pivotal to determining cancer patient prognosis and subsequent medical intervention. Here, we found that compared to apical expression...

Li-li Ma, Li-li Guo, Yang Luo, Guang-long Liu, Yan Lei… in Cell Death & Disease (2020)

Article

Genome-wide association study reveals new loci for yield-related traits in Sichuan wheat germplasm under stripe rust stress

As one of the most important food crops in the world, increasing wheat (Triticum aestivum L.) yield is an urgent task for global food security under the continuous threat of stripe rust (caused by Puccinia striif...

Xueling Ye, Jian Li, Yukun Cheng, Fangjie Yao, Li Long, Yuqi Wang, Yu Wu… in BMC Genomics (2019)

Article

Transcriptome analysis reveals pathways facilitating the growth of tobacco powdery mildew in Arabidopsis

Powdery mildew (PM) fungi are biotrophic pathogens that rely on living hosts to survive and thrive. However, their colonization is restricted by host defenses at both the penetration and post-penetration stage...

Ran Li, Ling-Li Zhang, Xue-Mei Yang, **ao-Long Cao, Ying-Ge Wang… in Phytopathology Research (2019)

Article

Autophagy suppresses self-renewal ability and tumorigenicity of glioma-initiating cells and promotes Notch1 degradation

Autophagy is a vital process that involves degradation of long-lived proteins and dysfunctional organelles and contributes to cellular metabolism. Glioma-initiating cells (GICs) have the ability to self-renew,...

Zhennan Tao, Tao Li, Haiwen Ma, Yihan Yang, Chen Zhang, Long Hai… in Cell Death & Disease (2018)

Article

PLZF play as an indirect facilitator of thymic retention for the innate-like T-cells to aquire innate-like functions

**n Cao, **ao-xia Ma, Yu-jia Xue, Yan Zeng, **an-yu Zhang, Ying Lu… in Cell Death & Disease (2018)

Article

Degranulation of mast cells induced by gastric cancer-derived adrenomedullin prompts gastric cancer progression

Mast cells are prominent components of solid tumors and exhibit distinct phenotypes in different tumor microenvironments. However, their precise mechanism of communication in gastric cancer remains largely unc...

Yi-pin Lv, Liu-sheng Peng, Qi-hong Wang, Na Chen, Yong-sheng Teng… in Cell Death & Disease (2018)