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Article
Open AccessEfficient electrochemical reduction of nitrate to ammonia over metal-organic framework single-atom catalysts
The design and preparation of efficient catalysts for ammonia production under mild conditions is a desirable but highly challenging target. Here, we report a series of single-atom catalysts [M-SACs, M = Mn(II...
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Article
Nanoparticle targeting cGAS-STING signaling in disease therapy
The cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon (IFN) genes (cGAS-STING) signaling pathway is crucial for sensing abnormal DNA accumulation in the cytoplasm. Once b...
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Article
Open AccessUSP47 deficiency in mice modulates tumor infiltrating immune cells and enhances antitumor immune responses in prostate cancer
This study investigates the role of USP47, a deubiquitinating enzyme, in the tumor microenvironment and its impact on antitumor immune responses. Analysis of TCGA database revealed distinct expression patterns...
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Article
2023: Weather and Climate Extremes Hitting the Globe with Emerging Features
Globally, 2023 was the warmest observed year on record since at least 1850 and, according to proxy evidence, possibly of the past 100 000 years. As in recent years, the record warmth has again been accompanied...
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Article
Insight into structural degradation of NCMs under extreme fast charging process
Lithium-ion batteries (LIBs) with extreme fast charging (XFC) capability are considered an effective way to alleviate range anxiety for electric vehicle (EV) buyers. Owing to the high ionic and electronic cond...
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Article
NνDEx-100 conceptual design report
Observing nuclear neutrinoless double beta (0 \(\nu \beta \beta\) ν ...
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Open AccessThe high level of IL-1β in the serum of ACLF patients induces increased IL-8 expression in hUC-MSCs and reduces the efficacy of hUC-MSCs in liver failure
Stem cells play a therapeutic role mainly through immunoregulation. However, the immunomodulatory function of stem cells may be affected by inflammation-related factors in patients’ serum. Therefore, this stud...
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Article
Open AccessMeasurement of the \( ^{181} \) Ta( \(n,\gamma \) ) cross sections up to stellar s-process temperatures at the CSNS Back-n
The neutron capture cross section of \( ^{181} \) 181 ...
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Article
A genetically encoded sensor measures temporal oxytocin release from different neuronal compartments
Oxytocin (OT), a peptide hormone and neuromodulator, is involved in diverse physiological and pathophysiological processes in the central nervous system and the periphery. However, the regulation and functiona...
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Article
Open AccessDeep learning and ultrasound feature fusion model predicts the malignancy of complex cystic and solid breast nodules with color Doppler images
This study aimed to evaluate the performance of traditional-deep learning combination model based on Doppler ultrasound for diagnosing malignant complex cystic and solid breast nodules. A conventional statisti...
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Article
Self-aware circular response-guided attention for robust siamese tracking
Siamese trackers recently have achieved remarkable advancements in accuracy, yet the further improvement is subject to semantic interferences. An potential reason may be the lack of prior information in visual...
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Article
Open AccessCell therapy in end-stage liver disease: replace and remodel
Liver disease is prevalent worldwide. When it reaches the end stage, mortality rises to 50% or more. Although liver transplantation has emerged as the most efficient treatment for end-stage liver disease, its ...
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Article
Open AccessCigarette smoke increases susceptibility of alveolar macrophages to SARS-CoV-2 infection through inducing reactive oxygen species-upregulated angiotensin-converting enzyme 2 expression
Alveolar macrophages (AMs) are the drivers of pulmonary cytokine storm in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This study aimed to investigate clinical–regulatory factors for...
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Open AccessThe post-discharge co** difficulty of puerperal women in a middle and low-income tourist city during the COVID-19 pandemic
Since the coronavirus disease 2019 (COVID-19) pandemic outbreak, the incidence of mental health problems in perinatal women has been high, and particularly prominent in China which was the first country affect...
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Article
Modulation of somatosensation by transcranial magnetic stimulation over somatosensory cortex: a systematic review
Over the last three decades, transcranial magnetic stimulation (TMS) has gained popularity as a tool to modulate human somatosensation. However, the effects of different stimulation types on the multiple disti...
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Open AccessA decade of innovation to deepen the understanding of infectious diseases of poverty and foster their control and elimination
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Open AccessAcupuncture combined with auricular acupressure for smoking cessation and its effects on tobacco dependence and smoking behavior among Hong Kong smokers: a multicenter pilot clinical study
Acupuncture combined with auricular acupressure has been used as a complementary and alternative treatment for smoking cessation in Hong Kong for over 10 years. This study aimed to investigate the success rate...
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Article
STING inhibitor ameliorates LPS-induced ALI by preventing vascular endothelial cells-mediated immune cells chemotaxis and adhesion
Acute lung injury (ALI) is a common and devastating clinical disorder featured by excessive inflammatory responses. Stimulator of interferon genes (STING) is an indispensable molecule for regulating inflammati...
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Article
MRI-derived radiomics analysis improves the noninvasive pretreatment identification of multimodality therapy candidates with early-stage cervical cancer
To develop and validate a clinical-radiomics model that incorporates radiomics signatures and pretreatment clinicopathological parameters to identify multimodality therapy candidates among patients with early-...
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Article
PELO facilitates PLK1-induced the ubiquitination and degradation of Smad4 and promotes the progression of prostate cancer
PLK1 and Smad4 are two important factors in prostate cancer initiation and progression. They have been reported to play the opposite role in Pten-deleted mice, one is an oncogene, the other is a tumor suppress...
