55 Result(s)

Article

Van der Waals polarity-engineered 3D integration of 2D complementary logic

Vertical three-dimensional integration of two-dimensional (2D) semiconductors holds great promise, as it offers the possibility to scale up logic layers in the z axis^1–3. Indeed, vertical complementary field-effe...

Yimeng Guo, Jiangxu Li, Xuepeng Zhan, Chunwen Wang, Min Li, Biao Zhang… in Nature (2024)

Article

The Shigella kinase effector OspG modulates host ubiquitin signaling to escape septin-cage entrapment

Shigella flexneri is a Gram-negative bacterium causing severe bloody dysentery. Its pathogenesis is largely dictated by a plasmid-encoded type III secretion system (T3SS) and its associated effectors. Among these...

Wei **an, Jiaqi Fu, Qinxin Zhang, Chuang Li, Yan-Bo Zhao… in Nature Communications (2024)

Article

Author Correction: Meiotic protein SYCP2 confers resistance to DNA-damaging agents through R-loop-mediated DNA repair

Yumin Wang, Boya Gao, Luyuan Zhang, Xudong Wang, … in Nature Communications (2024)

Article

Optofluidic crystallithography for directed growth of single-crystalline halide perovskites

Crystallization is a fundamental phenomenon which describes how the atomic building blocks such as atoms and molecules are arranged into ordered or quasi-ordered structure and form solid-state materials. While...

Xue-Guang Chen, Linhan Lin, Guan-Yao Huang, **ao-Mei Chen… in Nature Communications (2024)

Article

Enantioselective functionalization of unactivated C(sp³)–H bonds through copper-catalyzed diyne cyclization by kinetic resolution

Site- and stereoselective C–H functionalization is highly challenging in the synthetic chemistry community. Although the chemistry of vinyl cations has been vigorously studied in C(sp³)–H functionalization reacti...

Yang-Bo Chen, Li-Gao Liu, Zhe-Qi Wang, Rong Chang, **n Lu, Bo Zhou… in Nature Communications (2024)

Article

Meiotic protein SYCP2 confers resistance to DNA-damaging agents through R-loop-mediated DNA repair

Drugs targeting the DNA damage response (DDR) are widely used in cancer therapy, but resistance to these drugs remains a major clinical challenge. Here, we show that SYCP2, a meiotic protein in the synaptonema...

Yumin Wang, Boya Gao, Luyuan Zhang, Xudong Wang, … in Nature Communications (2024)

Article

Follicle-stimulating hormone orchestrates glucose-stimulated insulin secretion of pancreatic islets

Follicle-stimulating hormone (FSH) is involved in mammalian reproduction via binding to FSH receptor (FSHR). However, several studies have found that FSH and FSHR play important roles in extragonadal tissue. H...

Yi Cheng, Hong Zhu, Jun Ren, Hai-Yan Wu, Jia-En Yu, Lu-Yang **… in Nature Communications (2023)

Article

Positive rate of wheat allergens in the Chinese allergic population: a systematic review and meta-analysis

In recent years, the prevalence of allergic diseases has increased significantly, causing great concern, and wheat, as one of the top 8 food allergens, is a common allergy trigger. Nevertheless, reliable estim...

Fengmei Yang, **nyi Zhao, Wenfeng Liu, Bo Zhou, Lili Deng… in Scientific Reports (2023)

Article

A randomized trial of Trendelenburg position for acute moderate ischemic stroke

We aim to explore the effect of head-down position (HDP), initiated within 24 hours of onset, in moderate anterior circulation stroke patients with probable large artery atherosclerosis (LAA) etiology. This in...

Hui-Sheng Chen, Nan-Nan Zhang, Yu Cui, **ao-Qiu Li, Cheng-Shu Zhou… in Nature Communications (2023)

Article

Establishment and validation of a plasma oncofetal chondroitin sulfated proteoglycan for pan-cancer detection

Various biomarkers targeting cell-free DNA (cfDNA) and circulating proteins have been tested for pan-cancer detection. Oncofetal chondroitin sulfate (ofCS), which distinctively modifies proteoglycans (PGs) of ...

Pei-Fen Zhang, Zi-Yi Wu, Wen-Bin Zhang, Yong-Qiao He, Kexin Chen… in Nature Communications (2023)

Article

Neural network-based prediction of the secret-key rate of quantum key distribution

Numerical methods are widely used to calculate the secure key rate of many quantum key distribution protocols in practice, but they consume many computing resources and are too time-consuming. In this work, we...

Min-Gang Zhou, Zhi-** Liu, Wen-Bo Liu, Chen-Long Li, Jun-Lin Bai… in Scientific Reports (2022)

Article

MRNIP condensates promote DNA double-strand break sensing and end resection

The rapid recognition of DNA double-strand breaks (DSBs) by the MRE11/RAD50/NBS1 (MRN) complex is critical for the initiation of DNA damage response and DSB end resection. Here, we show that MRN complex intera...

Yun-Long Wang, Wan-Wen Zhao, Shao-Mei Bai, Li-Li Feng… in Nature Communications (2022)

Article

A specialized myodural bridge named occipital-dural muscle in the narrow-ridged finless porpoise (Neophocaena asiaeorientalis)

A dense bridge-like tissue named the myodural bridge (MDB) connecting the suboccipital muscles to the spinal dura mater was originally discovered in humans. However, recent animal studies have revealed that th...

Zhao-** Zhang, ** Gong, Sheng-Bo Yu, Chan Li, **g-**an Sun… in Scientific Reports (2021)

Article

Etiological, epidemiological, and clinical features of acute diarrhea in China

National-based prospective surveillance of all-age patients with acute diarrhea was conducted in China between 2009‒2018. Here we report the etiological, epidemiological, and clinical features of the 152,792 e...

Li-** Wang, Shi-**a Zhou, **n Wang, Qing-Bin Lu, Lu-Sha Shi… in Nature Communications (2021)

Article

Spatially interacting phosphorylation sites and mutations in cancer

Advances in mass-spectrometry have generated increasingly large-scale proteomics datasets containing tens of thousands of phosphorylation sites (phosphosites) that require prioritization. We develop a bioinfor...

Kuan-lin Huang, Adam D. Scott, Daniel Cui Zhou, Liang-Bo Wang… in Nature Communications (2021)

Article

Neurofilament light is a novel biomarker for mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is a complicated maternally inherited disorder lacking of sensitive and specific biomarkers. The objective of this study was t...

Yong-Sheng Zheng, Chong Sun, Rong Wang, Ne Chen, Su-Shan Luo… in Scientific Reports (2021)

Article

Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia

Identifying novel drug targets to overcome resistance to tyrosine kinase inhibitors (TKIs) and eradicating leukemia stem/progenitor cells are required for the treatment of chronic myelogenous leukemia (CML). H...

Hu Lei, Han-Zhang Xu, Hui-Zhuang Shan, Meng Liu, Ying Lu… in Nature Communications (2021)

Article

Molecular phylogeny inferred from the mitochondrial genomes of Plecoptera with Oyamia nigribasis (Plecoptera: Perlidae)

In this study, the mitochondrial genome of the stonefly, Oyamia nigribasis Banks, 1920 (Plecoptera: Perlidae), was sequenced and compared with the mtDNA genomes of 38 other stoneflies and two Ephemerae. The O. ni...

Meng-Yuan Zhao, Qing-Bo Huo, Yu-Zhou Du in Scientific Reports (2020)

Article

Aurora-A mediated phosphorylation of LDHB promotes glycolysis and tumor progression by relieving the substrate-inhibition effect

Overexpressed Aurora-A kinase promotes tumor growth through various pathways, but whether Aurora-A is also involved in metabolic reprogramming-mediated cancer progression remains unknown. Here, we report that ...

Aoxing Cheng, Peng Zhang, Bo Wang, Dongdong Yang, **aotao Duan… in Nature Communications (2019)