188 Result(s)
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Tracking cognitive trajectories in older survivors of COVID-19 up to 2.5 years post-infection
Emerging evidence suggests that neurological and other post-acute sequelae of COVID-19 can persist beyond or develop following SARS-CoV-2 infection. However, the long-term trajectories of cognitive change afte...
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Open AccessCommon dietary emulsifiers promote metabolic disorders and intestinal microbiota dysbiosis in mice
Dietary emulsifiers are linked to various diseases. The recent discovery of the role of gut microbiota–host interactions on health and disease warrants the safety reassessment of dietary emulsifiers through th...
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Open AccessCharacterization and the first complete genome sequence of a novel strain of Bergeyella porcorum isolated from pigs in China
Bergeyella porcorum is a newly identified bacterium that has an ambiguous relationship with pneumonia in pigs. However, few studies have adequately characterized this species.
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Open AccessOtud6b induces pulmonary arterial hypertension by mediating the Calpain-1/HIF-1α signaling pathway
Pulmonary hypertension (PAH) is a cardiopulmonary disease in which pulmonary artery pressure continues to rise, leading to right heart failure and death. Otud6b is a member of the ubiquitin family and is invol...
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Open AccessCirculating tumour cells predict recurrences and survival in head and neck squamous cell carcinoma patients
Patients with head and neck squamous cell carcinoma (HNSCC) are at a high risk of develo** recurrence and secondary cancers. This study evaluates the prognostic and surveillance utilities of circulating tumo...
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Open AccessAuthor Correction: Identification of an intraocular microbiota
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Open AccessCirc-0075305 hinders gastric cancer stem cells by indirectly disrupting TCF4–β-catenin complex and downregulation of SOX9
CircRNAs are covalently closed, single-stranded RNA that form continuous loops and play a crucial role in the initiation and progression of tumors. Cancer stem cells (CSCs) are indispensable for cancer develop...
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Open AccessUSP24-i-101 targeting of USP24 activates autophagy to inhibit drug resistance acquired during cancer therapy
Drug resistance in cancer therapy is the major reason for poor prognosis. Addressing this clinically unmet issue is important and urgent. In this study, we found that targeting USP24 by the specific USP24 inhi...
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Open AccessUnveiling the ventral morphology of a rare early Cambrian great appendage arthropod from the Chengjiang biota of China
The early Cambrian arthropod clade Megacheira, also referred to as great appendage arthropods, comprised a group of diminutive and elongated predators during the early Palaeozoic era, around 518 million years ...
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Open AccessEffects of four bolete species on ectomycorrhizae formation and development in Pinus thunbergii and Quercus acutissima
Bolete cultivation is economically and ecologically valuable. Ectomycorrhizae are advantageous for plant development and productivity. This study investigated how boletes affect the formation of Pinus thunbergii ...
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Open AccessIdentification of the role of DAB2 and CXCL8 in uterine spiral artery remodeling in early-onset preeclampsia
Aberrant remodeling of uterine spiral arteries (SPA) is strongly associated with the pathogenesis of early-onset preeclampsia (EOPE). However, the complexities of SPA transformation remain inadequately underst...
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Open AccessPotential scale of industrial outputs of the bronze bell casting industry in 500 BCE China
The potential scale of industrial outputs in the ancient world is often underestimated in current archaeological studies due to the lack of surviving artifacts for validation of the production scale. However, ...
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Open AccessPhylogenomics resolves the higher-level phylogeny of herbivorous eriophyoid mites (Acariformes: Eriophyoidea)
Eriophyoid mites (Eriophyoidea) are among the largest groups in the Acariformes; they are strictly phytophagous. The higher-level phylogeny of eriophyoid mites, however, remains unresolved due to the limited n...
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Recent Advances in the Application of P(III)-Nucleophiles to Create New P−C Bonds through Michaelis–Arbuzov-Type Rearrangement
Organophosphorus compounds have long been considered valuable in both organic synthesis and life science. P(III)-nucleophiles, such as phosphites, phosphonites, and diaryl/alkyl phosphines, are particularly no...
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Open AccessKEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC
Immunotherapy has become a prominent first-line cancer treatment strategy. In non-small cell lung cancer (NSCLC), the expression of PD-L1 induces an immuno-suppressive effect to protect cancer cells from immun...
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Open AccessAuthor Correction: The cerebellum contributes to generalized seizures by altering activity in the ventral posteromedial nucleus
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Identifying keystone species in microbial communities using deep learning
Previous studies suggested that microbial communities can harbour keystone species whose removal can cause a dramatic shift in microbiome structure and functioning. Yet, an efficient method to systematically i...
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TRIM3 facilitates ferroptosis in non-small cell lung cancer through promoting SLC7A11/xCT K11-linked ubiquitination and degradation
Ferroptosis, a unique form of regulated necrotic cell death, is caused by excessive iron-dependent lipid peroxidation. However, the underlying mechanisms driving ferroptosis in human cancers remain elusive. In...
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Open AccessSequencing by avidity enables high accuracy with low reagent consumption
We present avidity sequencing, a sequencing chemistry that separately optimizes the processes of step** along a DNA template and that of identifying each nucleotide within the template. Nucleotide identifica...
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ZNF689 deficiency promotes intratumor heterogeneity and immunotherapy resistance in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is an aggressive disease characterized by remarkable intratumor heterogeneity (ITH), which poses therapeutic challenges. However, the clinical relevance and key determinant...
