14 Result(s)

Article

Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases

Mitotic catastrophe (MC), which occurs under dysregulated mitosis, represents a fascinating tactic to specifically eradicate tumor cells. Whether pyroptosis can be a death form of MC remains unknown. Proteasom...

Zhan-Li Chen, Chen **e, Wei Zeng, Rui-Qi Huang… in Signal Transduction and Targeted Therapy (2024)

Article

Correction: c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses

Xu-Yan Wang, Yuan Wei, Bo Hu, Yuan Liao… in Signal Transduction and Targeted Therapy (2024)

Article

CXXC finger protein 1 (CFP1) bridges the resha** of genomic H3K4me3 signature to the advancement of lung adenocarcinoma

Histone H3 lysine 4 trimethylation (H3K4me3) is a canonical chromatin modification associated with active gene transcription, playing a pivotal role in regulating various cellular functions. Components of the ...

Tao Fan, Chu **ao, Hengchang Liu, Yu Liu… in Signal Transduction and Targeted Therapy (2023)

Article

Cyclin L1 controls cardiomyocyte proliferation and heart repair after injury

Rui Gong, **nlu Gao, Yu Liu, Yifu Shen… in Signal Transduction and Targeted Therapy (2023)

Article

Biomarker and genomic analyses reveal molecular signatures of non-cardioembolic ischemic stroke

Acute ischemic stroke (AIS) is a major cause of disability and mortality worldwide. Non-cardioembolic ischemic stroke (NCIS), which constitutes the majority of AIS cases, is highly heterogeneous, thus requirin...

Lingling Ding, Yu Liu, **a Meng, Yong Jiang… in Signal Transduction and Targeted Therapy (2023)

Article

ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage

Myocardial ischemia/reperfusion (I/R) injury is a classic type of cardiovascular disease characterized by injury to cardiomyocytes leading to various forms of cell death. It is believed that irreversible myoca...

**ao-Hui Ma, Jiang-Han-Zi Liu, Chun-Yu Liu… in Signal Transduction and Targeted Therapy (2022)

Article

TRIM47 is a novel endothelial activation factor that aggravates lipopolysaccharide-induced acute lung injury in mice via K63-linked ubiquitination of TRAF2

Endothelial activation plays an essential role in the pathogenesis of sepsis-induced acute lung injury, however, the detailed regulatory mechanisms remain largely unknown. Here, we reported that TRIM47, an E3 ...

Yisong Qian, Ziwei Wang, Hongru Lin… in Signal Transduction and Targeted Therapy (2022)

Article

c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses

B cells secreting IL-10 functionally are recognized as functional regulatory B (B_reg) cells; however, direct evidence concerning the phenotype, regulation, and functional and clinical relevance of IL-10-secreting...

Xu-Yan Wang, Yuan Wei, Bo Hu, Yuan Liao… in Signal Transduction and Targeted Therapy (2022)

Article

Identifying a confused cell identity for esophageal squamous cell carcinoma

The cell identity of malignant cells and how they acquire it are fundamental for our understanding of cancer. Here, we report that esophageal squamous cell carcinoma (ESCC) cells display molecular features equ...

**angyu Pan, Jian Wang, Linjie Guo, Feifei Na… in Signal Transduction and Targeted Therapy (2022)

Article

Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion

Ischemic stroke represents a significant danger to human beings, especially the elderly. Interventions are only available to remove the clot, and the mechanism of neuronal death during ischemic stroke is still...

Qing-zhang Tuo, Yu Liu, … in Signal Transduction and Targeted Therapy (2022)

Article

Correction: Spontaneous apoptosis of cells in therapeutic stem cell preparation exert immunomodulatory effects through release of phosphatidylserine

Xuemei He, Weiqi Hong, **gyun Yang, Hong Lei… in Signal Transduction and Targeted Therapy (2022)

Article

Spontaneous apoptosis of cells in therapeutic stem cell preparation exert immunomodulatory effects through release of phosphatidylserine

Mesenchymal stem cell (MSC)-mediated immunomodulation has been harnessed for the treatment of human diseases, but its underlying mechanism has not been fully understood. Dead cells, including apoptotic cells h...

Xuemei He, Weiqi Hong, **gyun Yang, Hong Lei… in Signal Transduction and Targeted Therapy (2021)

Article

Targeting folate receptor β positive tumor-associated macrophages in lung cancer with a folate-modified liposomal complex

Tumor-associated macrophages (TAMs) facilitate cancer progression by promoting tumor invasion, angiogenesis, metastasis, inflammatory responses, and immunosuppression. Folate receptor β (FRβ) is overexpressed ...

Yan Tie, Heng Zheng, Zhiyao He, **gyun Yang… in Signal Transduction and Targeted Therapy (2020)

Article

Epigenetic drug library screening identified an LSD1 inhibitor to target UTX-deficient cells for differentiation therapy

UTX (also known as KDM6A), a histone 3 lysine 27 demethylase, is among the most frequently mutated epigenetic regulators in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Recent studies have ...

Baohong Wu, **angyu Pan, Xuelan Chen, Mei Chen… in Signal Transduction and Targeted Therapy (2019)