64 Result(s)

Article

Otud6b induces pulmonary arterial hypertension by mediating the Calpain-1/HIF-1α signaling pathway

Pulmonary hypertension (PAH) is a cardiopulmonary disease in which pulmonary artery pressure continues to rise, leading to right heart failure and death. Otud6b is a member of the ubiquitin family and is invol...

Yu Liu, Bailin Tang, Hongxin Wang, Meili Lu in Cellular and Molecular Life Sciences (2024)

Article

Circulating tumour cells predict recurrences and survival in head and neck squamous cell carcinoma patients

Patients with head and neck squamous cell carcinoma (HNSCC) are at a high risk of develo** recurrence and secondary cancers. This study evaluates the prognostic and surveillance utilities of circulating tumo...

** Zhang, Chameera Ekanayake Weeramange… in Cellular and Molecular Life Sciences (2024)

Article

Author Correction: Identification of an intraocular microbiota

Yuhua Deng, **aofei Ge, Yan Li, Bin Zou, **aofeng Wen, Weirong Chen… in Cell Discovery (2024)

Article

USP24-i-101 targeting of USP24 activates autophagy to inhibit drug resistance acquired during cancer therapy

Drug resistance in cancer therapy is the major reason for poor prognosis. Addressing this clinically unmet issue is important and urgent. In this study, we found that targeting USP24 by the specific USP24 inhi...

Ming-Jer Young, Shao-An Wang, Yung-Ching Chen, Chia-Yu Liu… in Cell Death & Differentiation (2024)

Article

Identification of the role of DAB2 and CXCL8 in uterine spiral artery remodeling in early-onset preeclampsia

Aberrant remodeling of uterine spiral arteries (SPA) is strongly associated with the pathogenesis of early-onset preeclampsia (EOPE). However, the complexities of SPA transformation remain inadequately underst...

Yu Liu, Lili Du, Shifeng Gu, **gying Liang… in Cellular and Molecular Life Sciences (2024)

Article

KEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC

Immunotherapy has become a prominent first-line cancer treatment strategy. In non-small cell lung cancer (NSCLC), the expression of PD-L1 induces an immuno-suppressive effect to protect cancer cells from immun...

**ghan Li, Daiwang Shi, Siyi Li, **ang Shi, Yu Liu, Yi Zhang… in Cell Death & Disease (2024)

Article

Comprehensive genomic profiling of breast cancers characterizes germline-somatic mutation interactions mediating therapeutic vulnerabilities

Germline-somatic mutation interactions are universal and associated with tumorigenesis, but their role in breast cancer, especially in non-Caucasians, remains poorly characterized. We performed large-scale pro...

Chao Chen, Cai-** Lin, Yu-Chen Pei, Ding Ma, Li Liao, Si-Yuan Li… in Cell Discovery (2023)

Article

Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P

Pyroptosis is a type of regulated cell death executed by gasdermin family members. However, how gasdermin-mediated pyroptosis is negatively regulated remains unclear. Here, we demonstrate that mannose, a hexos...

Yuan-li Ai, Wei-jia Wang, Fan-jian Liu, Wei Fang, Hang-zi Chen… in Cell Research (2023)

Article

The E3 ligase TRIM26 suppresses ferroptosis through catalyzing K63-linked ubiquitination of GPX4 in glioma

The selenium-containing enzyme GPX4 moonlights as a central regulator of ferroptosis, an iron-dependent, nonapoptotic form of regulated cell death caused by lipid peroxidation. Yet, little is known about the m...

Zhangjie Wang, Yuan **a, Yang Wang, Ruiqiu Zhu, Hongbo Li, Yu Liu… in Cell Death & Disease (2023)

Article

The BRCA1/BARD1 complex recognizes pre-ribosomal RNA to facilitate homologous recombination

The BRCA1/BARD1 complex plays a key role in the repair of DNA double-strand breaks (DSBs) in both somatic cells and germ cells. However, the underlying molecular mechanism by which this complex mediates DSB re...

Duo Wu, Huang Huang, Tenglong Chen, **aochen Gai, Qilin Li, Chunhui Wang… in Cell Discovery (2023)

Article

Multidirectional characterization of cellular composition and spatial architecture in human multiple primary lung cancers

Multiple primary lung cancers (MPLCs) pose diagnostic and therapeutic challenges in clinic. Here, we orchestrated the cellular and spatial architecture of MPLCs by combining single-cell RNA-sequencing and spat...

Yawei Wang, Di Chen, Yu Liu, Daiwang Shi, Chao Duan, **ghan Li… in Cell Death & Disease (2023)

Article

Subty**-based platform guides precision medicine for heavily pretreated metastatic triple-negative breast cancer: The FUTURE phase II umbrella clinical trial

Triple-negative breast cancer (TNBC) is a heterogeneous disease and lacks effective treatment. Our previous study classified TNBCs into four subtypes with putative therapeutic targets. Here, we report the fina...

Yin Liu, **u-Zhi Zhu, Yi **ao, Song-Yang Wu, Wen-Jia Zuo, Qiang Yu… in Cell Research (2023)

Article

Upregulation of KLK8 contributes to CUMS-induced hippocampal neuronal apoptosis by cleaving NCAM1

Neuronal apoptosis has been well-recognized as a critical mediator in the pathogenesis of depressive disorders. Tissue kallikrein-related peptidase 8 (KLK8), a trypsin-like serine protease, has been implicated...

Dan-Hong Xu, Jian-Kui Du, Shi-Yu Liu, Hui Zhang, Lu Yang… in Cell Death & Disease (2023)

Article

Tp53 haploinsufficiency is involved in hotspot mutations and cytoskeletal remodeling in gefitinib-induced drug-resistant EGFR^L858R-lung cancer mice

Tumor heterogeneity is the major factor for inducing drug resistance. p53 is the major defender to maintain genomic stability, which is a high proportion mutated in most of the cancer types. In this study, we ...

Yi-Shiang Wang, Ming-Jer Young, Chia-Yu Liu, Yung-Ching Chen… in Cell Death Discovery (2023)

Article

CircKIF4A promotes glioma growth and temozolomide resistance by accelerating glycolysis

Circular RNAs (circRNAs) are a kind of noncoding RNAs that have different biological functions. CircRNAs play very important parts in the progression of cancers. Nevertheless, the exact mechanism and function ...

Kui Luo, Aiqun Liu, Hao Wu, Qiang Liu, ** Dai, Yu Liu, Zhifei Wang in Cell Death & Disease (2022)

Article

The ASIC3-M-CSF-M2 macrophage-positive feedback loop modulates fibroblast-to-myofibroblast differentiation in skin fibrosis pathogenesis

Inflammation is one of the main pathological features leading to skin fibrosis and a key factor leading to the progression of skin fibrosis. Acidosis caused by a decrease in extracellular pH is a sign of the i...

Jun-Jie Wu, Zi-Li Sun, Si-Yu Liu, Zhong-Hua Chen, Zheng-Dong Yuan… in Cell Death & Disease (2022)