5 Result(s)
within
English
Life Sciences
Cancer Research
Cell Biology
**g Yu Liu
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Article
MLL3 loss drives metastasis by promoting a hybrid epithelial–mesenchymal transition state
Phenotypic plasticity associated with the hybrid epithelial–mesenchymal transition (EMT) is crucial to metastatic seeding and outgrowth. However, the mechanisms governing the hybrid EMT state remain poorly def...
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Article
CTCF–CTCF loops and intra-TAD interactions show differential dependence on cohesin ring integrity
The ring-like cohesin complex mediates sister-chromatid cohesion by encircling pairs of sister chromatids. Cohesin also extrudes loops along chromatids. Whether the two activities involve similar mechanisms of...
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Article
Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B
Netrins, a family of secreted molecules, have critical functions in axon guidance and cell migration during neuronal development1,2. In addition to its role as a chemotropic molecule, netrin-1 also acts as a surv...
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Article
Myosin X regulates netrin receptors and functions in axonal path-finding
Netrins regulate axon path-finding during development, but the underlying mechanisms are not well understood. Here, we provide evidence for the involvement of the unconventional myosin X (Myo X) in netrin-1 fu...
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Article
Involvement of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm
Cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-activated chloride channel expressed in a wide variety of epithelial cells, mutations of which are responsible for the hallmark defective ch...
