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Article
Evaluation of fragility fracture risk using deep learning based on ultrasound radio frequency signal
It was essential to identify individuals at high risk of fragility fracture and prevented them due to the significant morbidity, mortality, and economic burden associated with fragility fracture. The quantitat...
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Article
Open AccessAMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine
The shift of carbon utilization from primarily glucose to other nutrients is a fundamental metabolic adaptation to cope with decreased blood glucose levels and the consequent decline in glucose oxidation. AMP-...
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Article
Open AccessMetabolic engineering of Escherichia coli for the production of 5-aminolevulinic acid based on combined metabolic pathway modification and reporter-guided mutant selection (RGMS)
5-Aminolevulinic acid (ALA) recently received much attention due to its potential application in many fields such as medicine, nutrition and agriculture. Metabolic engineering is an efficient strategy to impro...
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Article
When cancer survivors are also caregivers: well-being of “dual-role” cancer survivors
As the life expectancy of cancer survivors continues to improve, cancer survivors start or resume their life roles as caregivers themselves. We aim to assess the associations between caregiving, cancer diagnos...
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Article
Equity, diversity, and inclusion in the Multinational Association for Supportive Care in Cancer: a global membership survey
Equity, diversity, and inclusion (EDI) are essential for healthcare organizations since they allow for the development of programs and initiatives that bring together diverse perspectives and knowledge. Global...
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Article
Open AccessCorrection: NOD2 attenuates osteoarthritis via reprogramming the activation of synovial macrophages
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Chapter and Conference Paper
A Substructure-Based Method for Evaluating Structural Deformation
In the present study, a method that integrates substructure coupling with the vortex lattice method (VLM) was introduced for the assessment of structural deformation. The aerodynamic force is solved by mean of...
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Chapter and Conference Paper
Influence of Kinematics on Aerodynamic Characteristics of an Albatross-Like Flexible Flap** Wing in Forward Flight
Flap** wings have attracted much attention in recent years due to various merits. Many efforts have been made to study the kinematics and flexibility of flap** wings. However, the kinematics of flap** wi...
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Article
Open AccessNOD2 attenuates osteoarthritis via reprogramming the activation of synovial macrophages
Synovial inflammation, which precedes other pathological changes in osteoarthritis (OA), is primarily initiated by activation and M1 polarization of macrophages. While macrophages play a pivotal role in the in...
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Article
Open AccessLow glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate
Glycolytic intermediary metabolites such as fructose-1,6-bisphosphate can serve as signals, controlling metabolic states beyond energy metabolism. However, whether glycolytic metabolites also play a role in co...
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Chapter and Conference Paper
Geometrically Nonlinear Static Aeroelastic Analysis Based on CFD/CSD Interaction Accelerated by Panel Method
High-fidelity computational aeroelasticity based on CFD/CSD coupling method can capture the nonlinear effects in both aerodynamic and structural aspects. In this paper, geometrically nonlinear static aeroelast...
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Chapter and Conference Paper
Flutter Analysis of Large Flexible Aircraft Based on Reduced Order Model
This paper developments approach for stable analysis in flight of large flexible aircraft. Considering geometrical nonlinearity, aircraft is divided into nonlinear wing components and linear fuselage component...
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Chapter and Conference Paper
Aerodynamics Characteristics and Flight Dynamics Analysis of Multi-body Aircraft
As a new aircraft concept composed of independent aircrafts, multi-body aircraft (MBA) is connected together by hinge in wing tip to wing tip configuration. The dynamic characteristics of this kind of aircraft...
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Chapter and Conference Paper
Study on Aerodynamic Characteristics of “Propeller/Wing” System with Overset Mesh Method
In this paper, the propeller unsteady aerodynamic and “propeller/wing” aerodynamic interaction are investigated using the Computational Fluid Dynamics (CFD) method. Based on the true three-dimensional (3D) pro...
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Chapter and Conference Paper
Research on the Curriculum System of Electronic Information Engineering for the Certification of Engineering Education
The curriculum system is very important in the professional training program, and it is also an important inspection link in the professional certification of engineering education. For electronic information ...
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Article
Open AccessClinical outcomes of de novo metastatic HER2-low breast cancer: a National Cancer Database Analysis
The development of novel anti-HER2 drugs opens new treatment options for women with breast cancers, including lower expression of HER2. The epidemiology and clinical outcome of metastatic HER2-low breast cance...
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Article
Open AccessMetabolic engineering of Escherichia coli BW25113 for the production of 5-Aminolevulinic Acid based on CRISPR/Cas9 mediated gene knockout and metabolic pathway modification
5-Aminolevulinic acid (ALA) recently received much attention due to its potential application in many fields. In this study, an ALA production strain of Escherichia coli was constructed by rational metabolic engi...
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Article
Open AccessTargeting EGFR-dependent tumors by disrupting an ARF6-mediated sorting system
Aberrant activation of EGFR due to overexpression or mutation is associated with poor prognosis in many types of tumors. Here we show that blocking the sorting system that directs EGFR to plasma membrane is a ...
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Article
Open AccessThe aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK
The activity of 5′-adenosine monophosphate-activated protein kinase (AMPK) is inversely correlated with the cellular availability of glucose. When glucose levels are low, the glycolytic enzyme aldolase is not ...
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Article
Open AccessMiR-92a/KLF4/p110δ regulates titanium particles-induced macrophages inflammation and osteolysis
As total joint replacement is widely applied for severe arthropathy, peri-prosthetic aseptic loosening as one of the main causes of implant failure has drawn wide attention. Wear particles such as titanium par...
