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Article
Bioinspired Polarized Optical Flow Enables Turbid Underwater Target Motion Estimation
Underwater target motion estimation is a challenge for ocean military and scientific research. In this work, we propose a method based on the combination of polarization imaging and optical flow for turbid und...
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Article
Open AccessGenome-Wide Identification and Expression Analysis of the STAT Family in Reeve’s Turtle (Mauremys reevesii)
The Stat (signal transducer and activator of transcription) gene family plays a vital role in regulating immunity and the processes of cellular proliferation, differentiation, and apoptosis across diverse organis...
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Article
Open AccessProto-oncogene c-Myb potentiates cisplatin resistance of ovarian cancer cells by downregulating lncRNA NKILA and modulating cancer stemness and LIN28A-let7 axis
Ovarian cancer is a major gynecological cancer that has poor prognosis associated mainly to its late diagnosis. Cisplatin is an FDA approved ovarian cancer therapy and even though the therapy is initially prom...
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Article
Open AccessClustering of lifestyle behaviours and analysis of their associations with MAFLD: a cross-sectional study of 196,515 individuals in China
The aggregation of lifestyle behaviours and their association with metabolic-associated fatty liver disease (MAFLD) remain unclear. We identified lifestyle patterns and investigated their association with the ...
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Article
The incompatibility between industrial restructuring and low-carbon economy: a comprehensive analysis
Numerous studies have demonstrated that the development of low-carbon economy and industrial restructuring cannot occur in a coordinated manner. However, academic literature does not provide further explanatio...
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Article
Bioinspired Underwater Navigation Using Polarization Patterns Within Snell’s Window
Aiming at the requirement of autonomous navigation capability of the underwater unmanned vehicle (UUV), a novel bionic method for underwater navigation based on polarization pattern within Snell’s window is pr...
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Article
Open AccessDevelopment and validation of a nomogram for predicting metabolic-associated fatty liver disease in the Chinese physical examination population
We aim to develop and validate a nomogram including readily available clinical and laboratory indicators to predict the risk of metabolic-associated fatty liver disease (MAFLD) in the Chinese physical examinat...
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Article
Revisited electrochemical gas evolution reactions from the perspective of gas bubbles
Electrochemical gas evolution reactions are common but essential in many electrochemical processes including water electrolysis. During these processes, gas bubbles are constantly nucleating on reaction interf...
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Chapter and Conference Paper
Three-Dimensional Force Sensor Based on Deep Learning
Human skin can accurately sense subtle changes of both normal and shear forces. However, tactile sensors applied to robots are challenging in decoupling 3D forces due to the inability to develop adaptive model...
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Article
Open AccessSARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling
Severe COVID-19 is associated with epithelial and endothelial barrier dysfunction within the lung as well as in distal organs. While it is appreciated that an exaggerated inflammatory response is associated wi...
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Article
Exosomal circ_0001190 Regulates the Progression of Gastric Cancer via miR-586/SOSTDC1 Axis
Gastric cancer (GC) is the fifth most common cancer, which has a significant impact on human health. Recent researches have shown that circular RNAs (circRNAs) could affect the progress of GC, but the mechanis...
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Article
Open AccessDiscovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells
SARS coronavirus 2 (SARS-CoV-2) has caused an ongoing global pandemic with significant mortality and morbidity. At this time, the only FDA-approved therapeutic for COVID-19 is remdesivir, a broad-spectrum anti...
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Article
Pollution Characteristics and Health Risk Assessment of Phthalate Esters in PSW Recycling Sites: A Typical Case Study
The concentrations of six priority phthalate esters (PAEs) in 700 soil samples and 110 sediment samples from an area in China containing plastic solid waste (PSW) recycling sites were determined. The total con...
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Article
Open AccessAn intranasal ASO therapeutic targeting SARS-CoV-2
The COVID-19 pandemic is exacting an increasing toll worldwide, with new SARS-CoV-2 variants emerging that exhibit higher infectivity rates and that may partially evade vaccine and antibody immunity. Rapid dep...
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Article
Thermodynamic analysis of a novel adiabatic compressed air energy storage system with water cycle
A novel water cycle compressed air energy storage system (WC-CAES) is proposed to improve the energy storage density (ESD) and round trip efficiency (RTE) of A-CAES. The new system decreases electricity consum...
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Article
Open AccessDeep whole-genome resequencing sheds light on the distribution and effect of amphioxus SNPs
Amphioxus is a model organism for vertebrate evolutionary research. The significant contrast between morphological phenotypic similarity and high-level genetic polymorphism among amphioxus populations has arou...
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Article
Open AccessSecondary structural ensembles of the SARS-CoV-2 RNA genome in infected cells
SARS-CoV-2 is a betacoronavirus with a single-stranded, positive-sense, 30-kilobase RNA genome responsible for the ongoing COVID-19 pandemic. Although population average structure models of the genome were rec...
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Article
Critical thinking on amyloid-beta-targeted therapy: challenges and perspectives
Amyloid-beta (Aβ) plays a pivotal role in the pathogenesis of Alzheimer’s disease (AD) and has been regarded as the main therapeutic target for AD. However, most of the Aβ-targeted clinical trials have not suc...
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Article
Open AccessStructural basis of GABARAP-mediated GABAA receptor trafficking and functions on GABAergic synaptic transmission
GABAA receptors (GABAARs) are the primary fast inhibitory ion channels in the central nervous system. Dysfunction of trafficking and localization of GABAARs to cell membranes is clinically associated with severe ...
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Article
Open AccessCapsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice
Alzheimer’s disease (AD) is the most common cause of age-related dementia and is currently incurable. The failures of current clinical trials and the establishment of modifiable risk factors have shifted the A...
