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Chapter
The Internalization and Intracellular Trafficking of ADCs
Internalization is thought to be an important process during the antibody-based therapeutics. As ADC internalizes, it is transported to lysosome for degradation and payload is released to target intracellular ...
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Chapter
Antibody-Drug Conjugates: Basic Concepts and Structures
Antibody-drug conjugates (ADCs) are new modality of anticancer therapeutics. To enhance the translation, three components of an ADC drug—antibody, linker, and cytotoxin— need to be carefully optimized. The sel...
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Book
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Article
Synthesis and characterization of a series of carbamate-linked cationic lipids for gene delivery
A series of pH-sensitive lipids, 1a-h [(2,3-bis-alkyl-carbamoyloxy-propyl)-trialkylammonium halide] and 2a-d (1-dimethylamino-2,3-bis-alkylcarbamoyloxy-propane), with carbamate linkages between the hydrocarbon ch...