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Chapter
The Internalization and Intracellular Trafficking of ADCs
Internalization is thought to be an important process during the antibody-based therapeutics. As ADC internalizes, it is transported to lysosome for degradation and payload is released to target intracellular ...
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Chapter
Antibody-Drug Conjugates: Basic Concepts and Structures
Antibody-drug conjugates (ADCs) are new modality of anticancer therapeutics. To enhance the translation, three components of an ADC drug—antibody, linker, and cytotoxin— need to be carefully optimized. The sel...
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Book
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Article
Open AccessDYRK2 downregulation in colorectal cancer leads to epithelial–mesenchymal transition induction and chemoresistance
Colorectal cancer (CRC) is among the most prominent causes of cancer-associated mortality in the world, with chemoresistance representing one of the leading causes of treatment failure. However, the mechanisms...
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Article
Open AccessCorrection to: Homologous targeting nanoparticles for enhanced PDT against osteosarcoma HOS cells and the related molecular mechanisms
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Article
Open AccessHomologous targeting nanoparticles for enhanced PDT against osteosarcoma HOS cells and the related molecular mechanisms
No prominent advancements in osteosarcoma (OS) treatment have been made in the past 20 years. Although photodynamic therapy (PDT) is an emerging technique for cancer therapy, the lack of targeted photosensitiz...
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Article
Open AccessRhoA enhances osteosarcoma resistance to MPPa-PDT via the Hippo/YAP signaling pathway
Osteosarcoma (OS) is the most prevalent primary bone malignancy affecting adolescents, yet the emergence of chemoradiotherapeutic resistance has limited efforts to cure affected patients to date. Pyropheophorb...
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Article
A Hénon-like map inspired by the generalized discrete-time FitzHugh–Nagumo model
The patterns of discharge activity are closely associated with the physiological manifestation of neurons, and hence, it is particularly significant to understand the dynamic behavior of the patterns. In this ...
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Article
Efficient development and expression of scFv recombinant proteins against PD-L1 surface domain and potency in cancer therapy
PD-L1 is a 40 kDa trans-membrane protein of B7 family and an important T cell regulator. Binding of PD-L1 and PD-1 inhibits proliferation and activation of T cell results cell exhaustion. This phenomenon can b...
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Article
Mixed-mode oscillations and bifurcation analysis in a pituitary model
Bursting is an intrinsically electrical activity in excitable cells such as endocrine cells and many types of neurons. Our purpose is to recognize the pituitary model from a new perspective and provide guidanc...
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Article
Recombinant ω-Conotoxin MVIIA Possesses Strong Analgesic Activity
ω-Conotoxin (CTX) MVIIA is a specific antagonist of N-type voltage-sensitive calcium channels. A synthetic peptide version of CTX MVIIA (ziconotide) has been approved by the US FDA for severe and chronic pain....
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Article
Synthesis and characterization of a series of carbamate-linked cationic lipids for gene delivery
A series of pH-sensitive lipids, 1a-h [(2,3-bis-alkyl-carbamoyloxy-propyl)-trialkylammonium halide] and 2a-d (1-dimethylamino-2,3-bis-alkylcarbamoyloxy-propane), with carbamate linkages between the hydrocarbon ch...
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Article
Modification of ricin A chain, by addition of endoplasmic reticulum (KDEL) or Golgi (YQRL) retention sequences, enhances its cytotoxicity and translocation
A pKK expression system in Escherichia coli was used to produce recombinant ricin A chain (rRTA) and rRTA modified by addition of organelle-specific amino acid retention sequences, including KDEL (an endoplas...
