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Article
Structural and mechanistic basis for nucleosomal H2AK119 deubiquitination by single-subunit deubiquitinase USP16
Epigenetic regulators have a crucial effect on gene expression based on their manipulation of histone modifications. Histone H2AK119 monoubiquitination (H2AK119Ub), a well-established hallmark in transcription...
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Article
Open AccessEffects and mechanisms of Porphyromonas gingivalis outer membrane vesicles induced cardiovascular injury
The outer membrane vesicles (OMVs) derived from Porphyromonas gingivalis (P. gingivalis) have long been acknowledged for their crucial role in the initiation of periodontitis. However, the implications of P. ging...
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Article
Absorbable Clips Applied in Thoracoscopic Anatomical Lung Resection in Younger Children
This study aims to evaluate the feasibility and safety of a 5-mm absorbable clips applied in thoracoscopic anatomical lung resection in younger children.
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Article
Learning curve for total thoracoscopic segmentectomy in treating pediatric patients with congenital lung malformation
Total thoracoscopic segmentectomy (TTS) is a technically challenging procedure in children but results in more parenchyma preservation, better pain control, better cosmetic results, and a shorter hospital stay...
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Article
Open AccessPrevious pulmonary infection impacts thoracoscopic procedure outcomes in patients with congenital lung malformations: a retrospective cohort study
Patients with congenital lung malformations (CLMs) are at high risk for develo** pulmonary infection. Nonetheless, prophylactic surgical excision of asymptomatic CLMs is controversial and often delayed to sy...
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Article
Open AccessAccelerating corneal wound healing using exosome-mediated targeting of NF-κB c-Rel
The integrity of the corneal epithelium is essential for the maintenance of the physiological function of the cornea. Studies have found that inflammation greatly delays corneal wound healing. NF-κB c-Rel is p...
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Article
Correction to: Production and characterization of a novel interspecific somatic hybrid combining drought tolerance and high quality of sweet potato and Ipomoea triloba L
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Article
Production and characterization of a novel interspecific somatic hybrid combining drought tolerance and high quality of sweet potato and Ipomoea triloba L.
A novel interspecific somatic hybrid combining drought tolerance and high quality of sweet potato and Ipomoea triloba L. was obtained and its genetic and ep...
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Article
Open AccessMicroRNA-21 promotes pancreatic β cell function through modulating glucose uptake
Pancreatic β cell dysfunction contributes to the pathogenesis of type 2 diabetes. MiR-21 has been shown to be induced in the islets of glucose intolerant patients and type 2 diabetic mice. However, the role of...
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Article
Enhanced endosomal escape of dendrigraft poly-L-lysine polymers for the efficient gene therapy of breast cancer
Dendrimer, such as dendrigraft poly-L-lysine (DGL) polymers, with high surface charge density, well-defined structure, and narrow poly-dispersity is often employed as a gene vector, but its transfection effici...
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Article
Open AccessThe congenital sternoclavicular sinus: a single-institution retrospective study of 88 patients
Sinus near the sternoclavicular joint was considered as a rare congenital neck abnormality. Though it was reported as a dermoid sinus in some literatures, the embryological origin of the sinus was unclear. Thi...
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Article
Open AccessA novel sweetpotato bZIP transcription factor gene, IbbZIP1, is involved in salt and drought tolerance in transgenic Arabidopsis
The overexpression of IbbZIP1 leads to a significant upregulation of abiotic-related genes, suggesting that IbbZIP1 gene confers salt and drought tolerance in transgenic Arabidopsis.
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Article
Open AccessPotent anti-tumor immunostimulatory biocompatible nanohydrogel made from DNA
Unmethylated CpG oligodeoxynucleotides are potent immunostimulatory motifs in activating both innate and acquired immune system by inducing Th1 type antigen-specific T cell responses, but their instability in ...
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Article
Open AccessA soluble starch synthase I gene, IbSSI, alters the content, composition, granule size and structure of starch in transgenic sweet potato
Soluble starch synthase I (SSI) is a key enzyme in the biosynthesis of plant amylopectin. In this study, the gene named IbSSI, was cloned from sweet potato, an important starch crop. A high expression level of Ib...
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Article
Open AccessTranscript profile analysis reveals important roles of jasmonic acid signalling pathway in the response of sweet potato to salt stress
Sweet potato is an important food and bio-energy crop, and investigating the mechanisms underlying salt tolerance will provide information for salt-tolerant breeding of this crop. Here, the root transcriptomes...
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Article
Open AccessA genome-wide BAC-end sequence survey provides first insights into sweetpotato (Ipomoea batatas (L.) Lam.) genome composition
Sweetpotato, Ipomoea batatas (L.) Lam., is an important food crop widely grown in the world. However, little is known about the genome of this species because it is a highly heterozygous hexaploid. Gaining a more...
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Article
The Simultaneous Determination of Tricarboxylic Acid Cycle Acids and 2-Hydroxyglutarate in Serum from Patients with Nasopharyngeal Carcinoma Via GC–MS
The tricarboxylic acid (TCA) cycle has recently been in the spotlight in the field of oncology. Mutations in the enzymes called cytosolic isocitrate dehydrogenases (IDHs) are a common feature in several types ...
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Article
IbSIMT1, a novel salt-induced methyltransferase gene from Ipomoea batatas, is involved in salt tolerance
S-adenosyl-methionine (SAM)-dependent methyltransferase (MTase) genes are a multigene family; however, only a few have been characterized at the functional level. In the present study, a novel sa...
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Article
Overexpression of IbP5CR enhances salt tolerance in transgenic sweetpotato
Pyrroline-5-carboxylate reductase (P5CR) lies at the converging point of the glutamate and ornithine pathways and is the last and critical enzyme in proline biosynthesis. In the present study, a P5CR gene, named
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Article
A genetic linkage map based on AFLP and SSR markers and map** of QTL for dry-matter content in sweetpotato
We developed a genetic linkage map of sweetpotato using amplified fragment length polymorphism (AFLP) and simple sequence repeat (SSR) markers and a map** population consisting of 202 individuals derived fro...
