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Article
Open AccessARID1A loss derepresses a group of human endogenous retrovirus-H loci to modulate BRD4-dependent transcription
Transposable elements (TEs) through evolutionary exaptation have become an integral part of the human genome, offering ample regulatory sequences and sha** chromatin 3D architecture. While the functional imp...
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Chapter and Conference Paper
A Clonal Evolution Simulator for Planning Somatic Evolution Studies
Somatic evolution plays a key role in development, cell differentiation, and normal aging, but also diseases such as cancer. Understanding mechanisms of somatic mutability and how they can vary between cell li...
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Chapter and Conference Paper
Latent Sparse Discriminative Learning for Face Image Set Classification
Image set classification has drawn much attention due to its promising performance to overcome various variations. Recently, the point-to-point distance-based methods have achieved the state-of-the-art perform...
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Chapter and Conference Paper
Tumor Copy Number Deconvolution Integrating Bulk and Single-Cell Sequencing Data
Characterizing intratumor heterogeneity (ITH) is crucial to understanding cancer development, but it is hampered by limits of available data sources. Bulk DNA sequencing is the most common technology to assess...
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Chapter and Conference Paper
Phylogenies Derived from Matched Transcriptome Reveal the Evolution of Cell Populations and Temporal Order of Perturbed Pathways in Breast Cancer Brain Metastases
Metastasis is the mechanism by which cancer results in mortality and there are currently no reliable treatment options once it occurs, making the metastatic process a critical target for new diagnostics and th...
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Article
Collective effects of common SNPs and risk prediction in lung cancer
Lung cancer is the leading cause of cancer deaths in both men and women in the US. While most sporadic lung cancer cases are related to environmental factors such as smoking, genetic susceptibility may also pl...
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Article
Ultrafast preparation of a polyhedral oligomeric silsesquioxane-based ionic liquid hybrid monolith via photoinitiated polymerization, and its application to capillary electrochromatography of aromatic compounds
An ionic liquid hybrid monolithic capillary column was prepared within 7 min via photoinitiated free-radical polymerization of an ionic liquid monomer (1-butyl-3-vinylimidazolium-bis[(trifluoromethyl)sulfonyl]...
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Article
Open AccessAccumulation of minor alleles and risk prediction in schizophrenia
Schizophrenia is a common neuropsychiatric disorder with a lifetime risk of 1%. Accumulation of common polygenic variations has been found to be an important risk factor. Recent studies showed a role for the e...
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Article
Open AccessPromotion of behavior and neuronal function by reactive oxygen species in C. elegans
Reactive oxygen species (ROS) are well known to elicit a plethora of detrimental effects on cellular functions by causing damages to proteins, lipids and nucleic acids. Neurons are particularly vulnerable to R...
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Chapter and Conference Paper
Spatial Variability and Lateral Location of Soil Moisture Monitoring Points on Cotton Mulched Drip Irrigation Field
This experiment was conducted from April to September in 2009 in Baotou-lake Farm of Korla city, **njiang region, China. Two experiment schemes were designed for analyzing the spatial variability and lateral o...
