-
Article
Open AccessBiomolecular condensates with complex architectures via controlled nucleation
The structure and function of biomolecular condensates are closely related. However, many studies and applications of this relationship are prevented because controlling the mesoscale architecture of condensat...
-
Article
Open AccessTargeting nucleic acid phase transitions as a mechanism of action for antimicrobial peptides
Antimicrobial peptides (AMPs), which combat bacterial infections by disrupting the bacterial cell membrane or interacting with intracellular targets, are naturally produced by a number of different organisms, ...
-
Article
Amyloid formation as a protein phase transition
The formation of amyloid fibrils is a general class of protein self-assembly behaviour, which is associated with both functional biology and the development of a number of disorders, such as Alzheimer and Park...
-
Article
Open AccessSpatially non-uniform condensates emerge from dynamically arrested phase separation
The formation of biomolecular condensates through phase separation from proteins and nucleic acids is emerging as a spatial organisational principle used broadly by living cells. Many such biomolecular condens...
-
Article
Open AccessImpact of treatment modalities on prognosis of patients with metastatic renal collecting duct carcinoma
Although patients with renal collecting duct carcinoma (CDC) benefit from surgery, the value of cytoreductive nephrectomy (CNx) for the prognosis of patients with metastatic CDC remains unclear. Hence, in this...
-
Article
Open AccessThe role of reactive oxygen species derived from different NADPH oxidase isoforms and mitochondria in oxalate-induced oxidative stress and cell injury
Hyperoxaluria is a risk factor for urolithiasis and can cause renal epithelial cell injury secondary to oxidative stress. Reactive oxygen species (ROS) produced during cell damage originate from different sour...
-
Chapter and Conference Paper
Mining Generalised Emerging Patterns
Emerging Patterns (EPs) are a data mining model that is useful as a means of discovering distinctions inherently present amongst a collection of datasets. However, current EP mining algorithms do not handle at...
