5 Result(s)
within
**aoyong Pan
Biomedicine
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Article
Open AccessAttSiOff: a self-attention-based approach on siRNA design with inhibition and off-target effect prediction
Small interfering RNA (siRNA) is often used for function study and expression regulation of specific genes, as well as the development of small molecule drugs. Selecting siRNAs with high inhibition and low off...
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Article
Lentiviral delivery of co-packaged Cas9 mRNA and a Vegfa-targeting guide RNA prevents wet age-related macular degeneration in mice
Therapeutic genome editing requires effective and targeted delivery methods. The delivery of Cas9 mRNA using adeno-associated viruses has led to potent in vivo therapeutic efficacy, but can cause sustained Cas9 e...
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Article
Inferring novel genes related to oral cancer with a network embedding method and one-class learning algorithms
Oral cancer (OC) is one of the most common cancers threatening human lives. However, OC pathogenesis has yet to be fully uncovered, and thus designing effective treatments remains difficult. Identifying genes ...
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Article
HIV infection alters the human epigenetic landscape
Many complex diseases or traits are the results of both genetic and environmental factors. The environmental factors affect the human body by modifying its epigenetics, which controls the activity of genomes w...
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Article
Open AccessTranscriptomic landscape of lncRNAs in inflammatory bowel disease
Inflammatory bowel disease (IBD) is a complex multi-factorial inflammatory disease with Crohn’s disease (CD) and ulcerative colitis (UC) being the two most common forms. A number of transcriptional profiling s...
