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Open AccessYu Linzhu alleviates primary ovarian insufficiency in a rat model by improving proliferation and energy metabolism of granulosa cells through hif1α/cx43 pathway
Yu Linzhu (YLZ) is a classical Chinese traditional formula, which has been used for more than 600 years to regulate menstruation to help pregnancy. However, the mechanism of modern scientific action of YLZ nee...
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Article
Open AccessPlasma cell-free DNA 5-hydroxymethylcytosine and whole-genome sequencing signatures for early detection of esophageal cancer
Esophageal cancer is a highly incidence and deadly disease with a poor prognosis, especially in develo** countries. Owing to the lack of specific symptoms and early diagnostic biomarkers, most patients are d...
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Open AccessRetraction Note: Forecasting algorithm of tourism service trade based on PSO-optimized hybrid RVM model
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Open AccessRETRACTED ARTICLE: Forecasting algorithm of tourism service trade based on PSO-optimized hybrid RVM model
As a comprehensive form of trade, tourism service trade has had a profound impact on the economies of various countries. This research mainly discusses the tourism service trade forecasting algorithm based on ...
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Article
Open AccessCardiovascular characteristics of patients initially diagnosed breast cancer
We aimed to explore the cardiovascular characteristics of patients who were initially diagnosed with breast cancer.
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Open AccessMolecular epidemiology and genetic diversity of norovirus among hospitalized children with acute gastroenteritis in Tian**, China, 2018–2020
Norovirus (NoV) is a major cause of viral acute gastroenteritis (AGE) in children worldwide. Epidemiological analysis with respect to the virus strains is limited in China. This study aimed to investigate the ...
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Article
Open AccessDietary flaxseed oil rich in omega-3 suppresses severity of type 2 diabetes mellitus via anti-inflammation and modulating gut microbiota in rats
Type 2 diabetes mellitus (T2DM) is closely associated with hyperglycemia, abnormal lipid profiles, chronic low-grade inflammation and gut dysbiosis. Dietary intervention plays a crucial role in the control of ...
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Article
Open AccessIRGS: an immune-related gene classifier for lung adenocarcinoma prognosis
Tumour cells interfere with normal immune functions by affecting the expression of some immune-related genes, which play roles in the prognosis of cancer patients. In recent years, immunotherapy for tumours ha...
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The History of Zhongguancun
The Zhongguancun area was formerly an old river way for the Yongding River, which was known to Bei**g residents as “Zhong Wan er (or Middle Bay).” As early as the Ming Dynasty, the area’s picturesque scenery ...
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Article
Open AccessmTOR Overactivation in Mesenchymal cells Aggravates CCl4− Induced liver Fibrosis
Hepatic stellate cells are of mesenchymal cell type located in the space of Disse. Upon liver injury, HSCs transactivate into myofibroblasts with increase in expression of fibrillar collagen, especially collag...