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Article
Open AccessRapid and Sustained Effect of Ixekizumab on Patient Global, Spinal Pain, Stiffness, and Fatigue in Chinese Patients with Radiographic Axial Spondyloarthritis
Ixekizumab, an interleukin 17A (IL-17A) inhibitor, has demonstrated rapid and sustained improvement in the signs and symptoms in patients with active radiographic axial spondyloarthritis (r-axSpA) in global an...
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Article
Open AccessCRISPR/Cas9 Mediated Deletion of the Uox Gene Generates a Mouse Model of Hyperuricemia with Multiple Complications
Hyperuricemia is a common metabolic disorder with severe complications. We aimed to develop a mouse model for spontaneous hyperuricemia. Uox-/- mouse model was generated on C57BL/6J background by deleting exon 2-...
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Article
Reflective assessment using analytics and artifacts for scaffolding knowledge building competencies among undergraduate students
Knowledge building (KB) competencies are crucial for undergraduates’ creative knowledge work and academic success. While there is substantial research on KB discourse, there are limited efforts in examining ho...
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Article
The influences of ChatGPT on undergraduate students’ demonstrated and perceived interdisciplinary learning
The significance of interdisciplinary learning has been well-recognized by higher education institutions. However, when teaching interdisciplinary learning to junior undergraduate students, their limited disci...
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Article
Metadiscourse, knowledge advancement, and emotions in primary school students’ knowledge building
Knowledge Building principles such as real ideas, authentic problems; epistemic agency; and collective responsibility for advancement of community knowledge convey ways in which Knowledge Building mirrors work...
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Article
Open AccessAn interpretable model based on graph learning for diagnosis of Parkinson’s disease with voice-related EEG
Parkinson’s disease (PD) exhibits significant clinical heterogeneity, presenting challenges in the identification of reliable electroencephalogram (EEG) biomarkers. Machine learning techniques have been integr...
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Chapter and Conference Paper
A Virtual Reality Escape Room Game for Learning Computer Architecture Concepts
The application of virtual Reality (VR) games in education has been explored in recent years with successful outcomes in promoting student engagement and motivation. Escape room, an increasingly popular form o...
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Chapter and Conference Paper
Enhancing the Analysis of Interdisciplinary Learning Quality with GPT Models: Fine-Tuning and Knowledge-Empowered Approaches
Assessing the interdisciplinary learning quality of student learning processes is significant but complex. While some research has experimented with ChatGPT for qualitative analysis of text data through crafti...
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Chapter and Conference Paper
Leveraging Large Language Models for Automated Chinese Essay Scoring
Automated Essay Scoring (AES) plays a crucial role in offering immediate feedback, reducing the workload of educators in grading essays, and improving students’ learning experiences. With strong generalization...
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Article
Using learning analytics to explore the multifaceted engagement in collaborative learning
Engagement is critical in learning, including computer-supported collaborative learning (CSCL). Previous studies have mainly measured engagement using students’ self-reports which usually do not capture the le...
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Article
Open AccessIdentifying self-reported health-related problems in home-based rehabilitation of older patients after hip replacement in China: a machine learning study based on Omaha system theory
With the aging of the population, the number of total hip replacement surgeries is increasing globally. Hip replacement has undergone revolutionary advancements in surgical methods and materials. Due to the sh...
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Article
High-dose radiation-resistant lung cancer cells stored many functional lipid drops through JAK2/p-STAT3/FASN pathway
The understanding of radiation resistance is still unclear. This study aims to explore the new mechanism of radiation resistance in lung cancer from the perspective of lipid metabolism.
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Article
A Common Functional Variant at the Enhancer of the Rheumatoid Arthritis Risk Gene ORMDL3 Regulates its Expression Through Allele-Specific JunD Binding
Genome-wide association studies (GWASs) have identified over 100 loci associated with rheumatoid arthritis (RA); however, the functionally affected genes and the underlying molecular mechanisms contributing to...
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Article
Open AccessSafety and Effectiveness of a Novel Tips Access Set with Steerable Cannula in a Swine Model
This study aimed to assess the safety, effectiveness, and feasibility of the Liverty™ transjugular intrahepatic portosystemic shunt (TIPS) access set, which has an ergonomic handle that allows for in situ cannula...
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Article
Open AccessSpatio-temporal pattern and associate factors of intestinal infectious diseases in Zhejiang Province, China, 2008–2021: a Bayesian modeling study
Despite significant progress in sanitation status and public health awareness, intestinal infectious diseases (IID) have caused a serious disease burden in China. Little was known about the spatio-temporal pat...
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Article
B1-cell-produced anti-phosphatidylserine antibodies contribute to lupus nephritis development via TLR-mediated Syk activation
Autoantibodies produced by B cells play a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE). However, both the cellular source of antiphospholipid antibodies and their contributions to the...
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Article
Integrating infrared technologies in science learning: An evidence-based reasoning perspective
Infrared (IR) technologies have been universally acknowledged as a valuable pedagogical tool for exploring novel and abstract scientific subjects in science education. This study explores the roles of IR imag...
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Article
Profiles of personal and ecological assets: Adolescents’ motivation and engagement in self-driven learning
While opportunities for adolescents to drive their own learning are increasing, differences in motivations for and engagement in these opportunities are rarely investigated. The current study employed a sample...
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Article
Exploring Pre-service Teachers' Democratizing Knowledge in a Knowledge Building Community: Indicators and Results
Democratizing knowledge is about empowering all participants to be legitimate contributors to a group's shared goals and hel** them take pride in advancing community knowledge. It is a crucial principle of K...
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Article
Open AccessPrognostic value of cell-free DNA in cerebrospinal fluid from lung cancer patients with brain metastases during radiotherapy
During the last decades, radiotherapy (RT) for non-small cell lung cancer (NSCLC) with brain metastases (BM) has been developed. However, the lack of predictive biomarkers for therapeutic responses has limited...
