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Article
Theoretical investigation of Aryl/Alkyl halide reduction with hydrated electrons from energy and AIMD aspects
In this study, the reactions of hydrated electron (e−(aq)) with alkyl and aryl halides were simulated with an ab initial molecular dynamics (AIMD) method to reveal the underlying mechanism. An original protocol w...
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Article
Open AccessRatiometric electrochemical OR gate assay for NSCLC-derived exosomes
Non-small cell lung cancer (NSCLC) is the most common pathological type of LC and ranks as the leading cause of cancer deaths. Circulating exosomes have emerged as a valuable biomarker for the diagnosis of NSC...
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Article
Systematic and comprehensive strategy for metabolite profiling in bioanalysis using software-assisted HPLC-Q-TOF: magnoflorine as an example
Metabolite profiling plays a crucial role in drug discovery and development, and HPLC–Q-TOF has evolved into a powerful and effective high-resolution analytical tool for metabolite detection. However, traditio...
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Article
Study on the PK profiles of magnoflorine and its potential interaction in Cortex phellodendri decoction by LC-MS/MS
Magnoflorine, an aporphine alkaloid in Cortex phellodendri, is increasingly attracting research attention because of its antidiabetic effects. However, at present, little information on its pharmacokinetics (PK) ...