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Article
Theoretical investigation of Aryl/Alkyl halide reduction with hydrated electrons from energy and AIMD aspects
In this study, the reactions of hydrated electron (e−(aq)) with alkyl and aryl halides were simulated with an ab initial molecular dynamics (AIMD) method to reveal the underlying mechanism. An original protocol w...
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Article
Open AccessRatiometric electrochemical OR gate assay for NSCLC-derived exosomes
Non-small cell lung cancer (NSCLC) is the most common pathological type of LC and ranks as the leading cause of cancer deaths. Circulating exosomes have emerged as a valuable biomarker for the diagnosis of NSC...
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Article
Open AccessYAP 5-methylcytosine modification increases its mRNA stability and promotes the transcription of exosome secretion-related genes in lung adenocarcinoma
YAP is a transcriptional co-activator with critical roles in tumorigenesis. However, its upstream regulatory mechanism, especially how its mRNA stability is regulated, remains to be further studied. Here, we v...
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Article
Weakly Supervised Anomaly Detection Based on Two-Step Cyclic Iterative PU Learning Strategy
Weakly supervised anomaly detection for surveillance video is a highly challenging task due to inaccurate label information and sparse and diverse distribution of abnormal samples. In this paper, we define the...
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Article
Open AccessYAP ISGylation increases its stability and promotes its positive regulation on PPP by stimulating 6PGL transcription
Yes-associated protein (YAP) activation is crucial for tumor formation and development, and its stability is regulated by ubiquitination. ISGylation is a type of ubiquitination like post-translational modifica...
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Article
Open AccessThe essential roles of m6A RNA modification to stimulate ENO1-dependent glycolysis and tumorigenesis in lung adenocarcinoma
Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer. Patient prognosis is poor, and the existing therapeutic strategies for LUAD are far from satisfactory. Recently, targeting N6-methyladenos...
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Article
Open AccessCorrection to: Identifying the active components of Baihe–Zhimu decoction that ameliorate depressive disease by an effective integrated strategy: a systemic pharmacokinetics study combined with classical depression model tests
In the original publication of this article [1], another affiliation (Affiliation 3: University of Chinese Academy of Sciences, Bei**g 100049, People’s Republic of China.) for the author Ziqiong Guo is missin...
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Open AccessIdentifying the active components of Baihe–Zhimu decoction that ameliorate depressive disease by an effective integrated strategy: a systemic pharmacokinetics study combined with classical depression model tests
Modern pharmacological studies have demonstrated that Baihe–Zhimu decoction (BZD) has antidepressant effects. However, the complex composition and lack of clear evaluation standards for BZD make it less likely...
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Article
Functional characterization of two alkane hydroxylases in a versatile Pseudomonas aeruginosa strain NY3
Pseudomonas aeruginosa strain NY3 has an extraordinary capacity to utilize a wide range of substrates, including n–alkanes of lengths C5 to C34, aromatic compounds, phenols, diesel and cr...
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Article
Open AccessComplete Defluorination of Perfluorinated Compounds by Hydrated Electrons Generated from 3-Indole-acetic-acid in Organomodified Montmorillonite
Here we describe a unique process that achieves complete defluorination and decomposition of perfluorinated compounds (PFCs) which comprise one of the most recalcitrant and widely distributed classes of toxic ...
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Article
Systematic and comprehensive strategy for metabolite profiling in bioanalysis using software-assisted HPLC-Q-TOF: magnoflorine as an example
Metabolite profiling plays a crucial role in drug discovery and development, and HPLC–Q-TOF has evolved into a powerful and effective high-resolution analytical tool for metabolite detection. However, traditio...
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Study on the PK profiles of magnoflorine and its potential interaction in Cortex phellodendri decoction by LC-MS/MS
Magnoflorine, an aporphine alkaloid in Cortex phellodendri, is increasingly attracting research attention because of its antidiabetic effects. However, at present, little information on its pharmacokinetics (PK) ...
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Article
Open AccessMolecular characterization of China rabies virus vaccine strain
Rabies virus (RV), the agent of rabies, can cause a severe encephalomyelitis in several species of mammals, including humans. As a human rabies vaccine strain employed in China, the genetic knowledge of the aG...
