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Article
Open AccessBrain pharmacokinetics of two BBB penetrating bispecific antibodies of different size
Transferrin receptor (TfR1) mediated enhanced brain delivery of antibodies have been studied extensively in preclinical settings. However, the brain pharmacokinetics, i.e. brain entry, distribution and elimina...
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Article
Quantification of SV2A Binding in Rodent Brain Using [18F]SynVesT-1 and PET Imaging
Synapse loss is a hallmark of Alzheimer’s disease (AD) and correlates with cognitive decline. The validation of a noninvasive in vivo imaging approach to quantify synapse would greatly facilitate our understandin...
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Article
Open AccessAstroglial Responses to Amyloid-Beta Progression in a Mouse Model of Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by amyloid-beta (Aβ) deposition, hyperphosphorylation of tau, and neuroinflammation. Astrocytes, the most abundant glial cell type in the ...
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Article
Open AccessPharmacokinetics, biodistribution and brain retention of a bispecific antibody-based PET radioligand for imaging of amyloid-β
Monoclonal antibodies (mAbs) have not been used as positron emission tomography (PET) ligands for in vivo imaging of the brain because of their limited passage across the blood-brain barrier (BBB). However, due t...
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Article
The Advent of Ultra-high Volume Thoracic Surgical Centers in Shanghai
A core principle in surgery is that high surgical volumes are conducive toward better outcomes. Ultra-high volume centers (UHVCs) have now emerged in thoracic surgery in China that now perform a volume of thor...
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Article
Open AccessEfficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells
Immunotherapy is a very fast expanding field within drug discovery and, hence, rapid and inexpensive expression of antibodies would be extremely valuable. Antibodies are, however, difficult to express. Multifu...
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Article
Open AccessAntibody-based PET imaging of amyloid beta in mouse models of Alzheimer’s disease
Owing to their specificity and high-affinity binding, monoclonal antibodies have potential as positron emission tomography (PET) radioligands and are currently used to image various targets in peripheral organ...
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Chapter and Conference Paper
A Practical Strategy to Study Stochastic Chaos
Stochastic chaos often appears in random nonlinear dynamic systems. Based on orthogonal polynomial approximation and ergodic theorem, a practical strategy for studying stochastic chaos is proposed and illustra...
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Article
Bifurcation and Chaos Analysis of Stochastic Duffing System Under Harmonic Excitations
The Chebyshev polynomial approximation is applied to the dynamic response problem of a stochastic Duffing system with bounded random parameters, subject to harmonic excitations. The stochastic Duffing system i...
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Article
Response Statistics of Three-Degree-of-Freedom Nonlinear System to Narrow-Band Random Excitation
The principal resonance of a 3-DOF nonlinear system to narrow-band random external excitations is investigated. The method of multiple scales is used to derive the equations for modulation of amplitude and pha...
