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Article
A Selective Human Bombesin Receptor Subtype-3 Peptide Agonist Mediates CREB Phosphorylation and Transactivation
The native ligand for the G protein-coupled bombesin receptor subtype-3 (BRS-3) has currently not been identified. Studies in mice showed robust BRS-3 expression in the hypothalamic satiety centers, and geneti...
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Article
Effects of Trimethoxystilbene on Proliferation and Apoptosis of Pulmonary Artery Smooth Muscle Cells
Proliferation of pulmonary artery smooth muscle cells (PASMC) is an important contributor to the progress of pulmonary arterial hypertension (PAH). Anti-inflammatory therapies may have therapeutic applicabilit...
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Article
An inactivated Pseudomonas aeruginosa medicament inhibits airway allergic inflammation and improves epithelial functions
The features of asthma are airway hyperresponsiveness (AHR), excess production of Th2 cytokines, and eosinophil accumulation in the lungs. To investigate the antiasthmatic potential of an inactivated Pseudomonas ...
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Article
Carbon cycle in the epikarst systems and its ecological effects in South China
The carbon cycle in a global sense is the biogeochemical process by which carbon is exchanged among the biosphere, pedosphere, geosphere, hydrosphere, and atmosphere of the earth. For epikarst systems, it is t...
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Chapter and Conference Paper
Problem-Based Learning (PBL) in Eight-Year Program of Clinical Medicine in **angya School of Medicine: New Mode Needs Exploration
Introduction Problem-based learning (PBL) is an educational method characterized by the use of patient problems as a context for students to learn problem-solving skills and to acquire knowledge on...
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Article
Estimation of carbon sink fluxes in the Pearl River basin (China) based on a water–rock–gas–organism interaction model
Carbon sequestration resulting from carbonate rock weathering is closely linked to the global carbon cycle and has turned out to be important in the adjustment of atmospheric CO2 levels. Traditional karst dynamic...
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Article
Characteristics of climate change in southwest China karst region and their potential environmental impacts
Global warming, due to the enhanced greenhouse effect, is likely to have significant effect on the hydrological cycle, which would result in more evaporation, more precipitation, and uneven distribution of pre...
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Article
Apelin-13 Impaires Acquisition but Not Consolidation or Expression of Contextual Fear in Rats
Apelin-13, as an endogenous neuropeptide, is the ligand for the G-protein-coupled receptor, APJ, which has recently been demonstrated to be involved in the process that contributes to learning and memory. Prev...
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Article
Open AccessITGB4 deficiency in bronchial epithelial cells directs airway inflammation and bipolar disorder-related behavior
Chronic persistent airway inflammation has been associated with the comorbidity of asthma and bipolar disorder (BD). However, the direct relevance between airway inflammation and BD-like psychiatric comorbidit...
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Article
Anomalous spontaneous electrical potential characteristics of epi-karst in the Longrui Depression, Southern Guangxi Province, China
This paper examines the use of the temporal and spatial distribution of natural electric fields in karst depressions to detect shallow groundwater resources. Under specific osmotic pressures, vadose water is f...
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Article
Open AccessVariable DNA methylation of aging-related genes is associated with male COPD
Chronic obstructive pulmonary disease (COPD) is a chronic lung inflammatory disease which has a close relationship with aging. Genome-wide analysis reveals that DNA methylation markers vary obviously with age....
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Article
Hydrochemical characteristics and karst carbon sink estimation under the influence of allogenic water
The water originating from non-karst area, i.e., allogenic water (AW), has low pH and low calcite saturation. After entering the karst area, the chemical weathering of carbonate rocks would be accelerated and ...
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Article
Influential factors and spatial suitability of the method of limestone tablets in karst carbon cycle study in China
As an intuitive way, the method of limestone tablets (MLT) is often used in dissolution rate calculation and carbon cycle research of carbonate rocks. To clarify the influential factors and spatial suitability...
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Article
Open AccessThe DNA methylation of FOXO3 and TP53 as a blood biomarker of late-onset asthma
Late-onset asthma (LOA) is beginning to account for an increasing proportion of asthma patients, which is often underdiagnosed in the elderly. Studies on the possible relations between aging-related genes and ...
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Article
Open AccessCorrection to: The DNA methylation of FOXO3 and TP53 as a blood biomarker of late-onset asthma
An amendment to this paper has been published and can be accessed via the original article.
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Article
Emodin Attenuates Ozone-Induced Lung Injury Via TLR4/MYD88/NF-κB Signaling Pathways
In defense of the internal and external environment of the lung airway, airway epithelial cells play important roles in resisting external microorganisms, toxic gases, sensitizing substances, and maintaining t...
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Article
Student fatigue and its impact on teaching effectiveness based on online teaching
Since the outbreak of COVID-19 in 2019, many countries have taken measures such as controlling the flow of people, logistics and reducing crowds. Educational institutions have shifted from traditional face-to-...
