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Article
Open AccessMulti-omics and single cell characterization of cancer immunosenescence landscape
Cellular senescence (CS) is closely related to tumor progression. However, the studies about CS genes across human cancers have not explored the relationship between cancer senescence signature and telomere le...
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Article
Immunotherapies for the Effective Treatment of Primary Autoimmune Cerebellar Ataxia: a Case Series
Primary autoimmune cerebellar ataxia (PACA) is an idiopathic sporadic cerebellar ataxia that is thought to be immune-mediated but lacks biomarkers or a known cause. Here, we report two cases of immune-mediated...
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Article
Open AccessChatGPT: when the artificial intelligence meets standardized patients in clinical training
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Article
The expression level of Neuronal Calcium Sensor 1 can predict the prognosis of cytogenetically normal AML
Acute myeloid leukemia (AML) is malignant clonal expansion of myeloid blasts with high heterogeneity and numerous molecular biomarkers have been found to judge the prognosis in some specific classifications of...
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Article
Characterization of neuroinflammation pattern in anti-LGI1 encephalitis based on TSPO PET and symptom clustering analysis
TSPO PET with radioligand [18F]DPA-714 is an emerging molecular imaging technique that reflects cerebral inflammation and microglial activation, and it has been recently used in central nervous system diseases. I...
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Article
Presence of Rare Variants is Associated with Poorer Survival in Chinese Patients with Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with phenotypic and genetic heterogeneity. Recent studies have suggested an oligogenic basis of ALS, in which the co-occurrence of two ...
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Article
Impact of Ridge-Furrow Rainwater Harvesting with Biochar Application on Soil Hydrothermal Condition, Nutrient, and Alfalfa Fodder Yield in the Loess Plateau in China
Alfalfa (Medicago sativa L.) production is constrained mainly by water deficit and poor soil fertility in the Loess Plateau in China. Ridge-furrow rainwater harvesting with biochar application could improve soil ...
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Article
Effects of ridge-furrow rainwater harvesting with biochar application on soil physical properties and alfalfa fodder yield in semiarid region in China
Erratic climatic conditions and poor intrinsic soil properties are major challenges constraining agricultural sustainability, resilience, and food security in the Loess Plateau in China. Thus, it is necessary ...
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Article
Global characterization of megakaryocytes in bone marrow, peripheral blood, and cord blood by single-cell RNA sequencing
Megakaryocytes (MK) are mainly derived from bone marrow and are mainly involved in platelet production. Studies have shown that MK derived from bone marrow may have immune function, and that MK from peripheral...
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Article
RDIVpSGP motif of ASPP2 binds to 14-3-3 and enhances ASPP2/k18/14-3-3 ternary complex formulation to promote BRAF/MEK/ERK signal inhibited cell proliferation in hepatocellular carcinoma
The Apoptosis Stimulating Protein of p53 2 (ASPP2) is a heterozygous insufficient tumor suppressor; however, its molecular mechanism(s) in tumor suppression is not completely understood. ASPP2 plays an essenti...
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Article
Open AccessHeterogeneity induced GZMA-F2R communication inefficient impairs antitumor immunotherapy of PD-1 mAb through JAK2/STAT1 signal suppression in hepatocellular carcinoma
Tumor heterogeneity has been associated with immunotherapy and targeted drug resistance in hepatocellular carcinoma (HCC). However, communications between tumor and cytotoxic cells are poorly understood to dat...
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Article
Open AccessKnockout of ASPP2 promotes DEN-induced hepatocarcinogenesis via the NF-κB pathway in mice
Apoptosis-stimulating protein p53 2 (ASPP2) is a member of the p53-binding protein family, which is closely related to tumor development. However, the precise mechanism of ASPP2 in liver inflammation and tumor...
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Article
Open AccessOptimal encephalitis/meningitis roadmap via precise diagnosis and treatment (IMPROVE): a study protocol for a randomized controlled trial
Encephalitis/meningitis brings a heavy disease burden, and the origin of disease remains unknown in 30–40% of patients. It is greatly significant that combinations of nucleic acid amplification and autoimmune ...
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Article
Open AccessAssociation study between genetic variants and the risk of schizophrenia in the Chinese population based on GWAS-implicated 6p21.3–23.1 human genome region: a case-control study
Schizophrenia is a polygenic disease; however, the specific risk genetic variants of schizophrenia are still largely unknown. Single nucleotide polymorphism (SNP) is important genetic factor for the susceptibi...
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Article
KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements
Tumours use various strategies to evade immune surveillance1,2. Immunotherapies targeting tumour immune evasion such as immune checkpoint blockade have shown considerable efficacy on multiple cancers3,4 but are i...
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Chapter and Conference Paper
Influence of Nanofluids Inlet and Outlet Positions on CPU Cooling Performance
In order to promote the development of CPU, the intensity of heat emission in limited heat transfer surface becomes larger and larger. Air, water, and ethylene glycol as the common cooling mediums cannot meet ...
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Article
Open AccessPrognosis value of RBBP8 expression in plasma cell myeloma
Plasma cell myeloma (PCM) secretes monoclonal immunoglobulin (Ig) by clonal plasma cells of abnormal proliferation in the bone marrow. As PCM is incurable, it is necessary to find new biomarkers to predict the...
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Article
Effect of Quenching Temperature on Microstructure and Properties of Al-Bearing High-Boron High-Speed Steel
Microstructure and properties of the alloys could be changed by heat treatment process. In this work, effect of quenching temperature on the microstructure of Al-bearing high-boron high-speed steel (AB-HSS) wa...
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Article
Open AccessThe Prognostic Significance of PDE7B in Cytogenetically Normal Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a malignant hematological disease in which nearly half have normal cytogenetics. We have tried to find some significant molecular markers for this part of the cytogenetic normal...
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Article
Open AccessHigh expression of UBE2T predicts poor prognosis and survival in multiple myeloma
Multiple myeloma (MM) is one of hematological malignancies, characterized by malignant proliferation of plasma cells. Biomarkers play an important role in evaluating the development and prognosis of MM. Ubiqui...
