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Article
Enhancing the Adhesion Interface Between Asphalt and Basalt Fibers Through Surface Modification with Titanate Coupling Agents
Basalt fiber is prone to slip and fall off in asphalt system. To improve the interfacial adhesion strength between basalt fibers (BFs) and asphalt, titanate coupling agents (TCAs) were applied to BF-reinforced...
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Article
Algorithms of isogeometric analysis for MIST-based structural topology optimization in MATLAB
In this paper, a new isogeometric topology optimization (ITO) method based on the moving iso-surface threshold (MIST) method is proposed, and the corresponding MATLAB code is provided. The same nonuniform rati...
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Article
Open AccessApplication of exponential smoothing method and SARIMA model in predicting the number of admissions in a third-class hospital in Zhejiang Province
To establish the exponential smoothing prediction model and SARIMA model to predict the number of inpatients in a third-class hospital in Zhejiang Province, and evaluate the prediction effect of the two models...
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Article
Open AccessApplication of problem based learning (PBL) and case based learning (CBL) in the teaching of international classification of diseases encoding
To study the application of PBL combined with CBL teaching mode in the teaching of international classification of diseases (ICD) encoding, so as to improve students' grasp of ICD encoding knowledge. From Marc...
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Article
Open AccessMolecular insights into Spindlin1-HBx interplay and its impact on HBV transcription from cccDNA minichromosome
Molecular interplay between host epigenetic factors and viral proteins constitutes an intriguing mechanism for sustaining hepatitis B virus (HBV) life cycle and its chronic infection. HBV encodes a regulatory ...
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Article
Open AccessCorrection: HBeAg mediates inflammatory functions of macrophages by TLR2 contributing to hepatic fibrosis
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Article
Open AccessHBeAg mediates inflammatory functions of macrophages by TLR2 contributing to hepatic fibrosis
We and others have confirmed activation of macrophages plays a critical role in liver injury and fibrogenesis during HBV infection. And we have also proved HBeAg can obviously induce the production of macropha...
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Article
Multi-scale topology optimization for minimizing structural compliance of cellular composites with connectable graded microstructures
This paper presents a multi-scale topology optimization method for connectable graded microstructures based on the moving iso-surface threshold (MIST) method, in which both the configuration of the microstruct...
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Article
Open AccessFN-EDA mediates angiogenesis of hepatic fibrosis via integrin-VEGFR2 in a CD63 synergetic manner
Pathological angiogenesis is an important component of hepatic fibrosis along with fibrous deposition, but its role is not well understood. Here, we demonstrated that fibronectin containing extra domain A(FN-E...
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Article
Develo** Spindlin1 small-molecule inhibitors by using protein microarrays
The use of protein microarrays containing human methyllysine effector molecules enabled discovery of a potent and selective inhibitor of the interaction of the Tudor-domain-containing protein Spindlin1 with H3...
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Article
Open AccessEHMT2 inhibitor BIX-01294 induces apoptosis through PMAIP1-USP9X-MCL1 axis in human bladder cancer cells
BIX-01294, an euchromatic histone-lysine N-methyltransferase 2 (EHMT2) inhibitor, has been reported to induce apoptosis in human neuroblastoma cells and inhibit the proliferation of bladder cancer cells. Howev...
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Article
Pricing options with credit risk in a reduced form model
This article investigates the valuation of European option with credit risk in a reduced form model. We assume that the interest rate follows the Vasicek model and the intensity of default is driven by a jump ...
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Article
Quantification of Doxorubicin in Pegylated Polymer Micelles in Rat Plasma by Methanol Precipitation–Ultrasonic Emulsion Breaking Method and UPLC–MS–MS
This study established a new methanol precipitation–ultrasonic emulsion breaking method for extraction of doxorubicin from polymeric micelles and developed a UPLC–MS/MS method for the determination of doxorubi...
