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Article
Open AccessChromosomal-scale genome assembly and annotation of the land slug (Meghimatium bilineatum)
Meghimatium bilineatum is a notorious pest land slug used as a medicinal resource to treat ailments in China. Although this no-model species is unique in terms of their ecological security and medicinal value, th...
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Article
Effects of climate change on the potential habitat distribution of swimming crab Portunus trituberculatus under the species distribution model
Over the last decades, the species distribution model (SDM) has become an essential tool for studying the potential effects of climate change on species distribution. In this study, an ensemble SDM was develop...
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Article
Semisolid Extrusion 3D Printing of Propranolol Hydrochloride Gummy Chewable Tablets: an Innovative Approach to Prepare Personalized Medicine for Pediatrics
The demand for personalized medicine has received extensive attention, especially in pediatric preparations. An emerging technology, extrusion-based 3D printing, is highly attractive in the field of personaliz...
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Article
Effect of Different Absorption Enhancers on the Nasal Absorption of Nalmefene Hydrochloride
The purpose of this work is to explore the effects of novel absorption enhancers on the nasal absorption of nalmefene hydrochloride (NMF). First, the influence of absorption enhancers with different concentrat...
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Article
Open AccessTaste Masking Study Based on an Electronic Tongue: the Formulation Design of 3D Printed Levetiracetam Instant-Dissolving Tablets
Proper taste-masking formulation design is a critical issue for instant-dissolving tablets (IDTs). The purpose of this study is to use the electronic tongue to design the additives of the 3D printed IDTs to im...
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Article
Open AccessLong-read sequencing and de novo assembly of a Chinese genome
Short-read sequencing has enabled the de novo assembly of several individual human genomes, but with inherent limitations in characterizing repeat elements. Here we sequence a Chinese individual HX1 by single-mol...
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Article
Ecological risks and potential sources of heavy metals in agricultural soils from Huanghuai Plain, China
A total of 224 agricultural soil samples from Huanghuai Plain in China were investigated for the concentrations of seven heavy metals (As, Cd, Cr, Hg, Ni, Pb, and Zn). The mean concentrations of the metals wer...
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Article
Open AccessThe association between XPC Lys939Gln gene polymorphism and urinary bladder cancer susceptibility: a systematic review and meta-analysis
Numerous epidemiological studies have been conducted to explore the association between the Lys939Gln polymorphism of Xeroderma pigmentosum group C (XPC) gene and urinary bladder cancer susceptibility. However...