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Article
H2S Regulates the Phenotypic Transformation of Astrocytes Following Cerebral Ischemia/Reperfusion via Inhibiting the RhoA/ROCK Pathway
The role of hydrogen sulfide (H2S) on the phenotypic change of astrocytes following cerebral ischemia/reperfusion (I/R) in mice was investigated in present study. We tested the expression of glial fibrillary acid...
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Article
Chemical and Molecular Profiling of Dissolved Organic Matter within Varied Compost: A Comprehensive Spectroscopic Study
Limited information is available regarding the chemical and molecular compositions and structures of dissolved organic matter (DOM) originating from diverse matured composts. In this study, the compost DOM ext...
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Article
Harnessing digital innovation for cultural heritage: a study on communicating West Lake folk tales through digital picture books
This study revolves around the design of digital picture books for the preservation and dissemination of West Lake folk tales, exploring their application and value in the inheritance of cultural heritage and ...
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Article
Open AccessAutomation of the meshing process of geological data
This work proposes a novel meshing technique that is able to extract surfaces from processed seismic data and integrate surfaces that were constructed using other extraction techniques. Contrary to other exist...
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Article
Open AccessFicolin 3 promotes ferroptosis in HCC by downregulating IR/SREBP axis-mediated MUFA synthesis
Targeting ferroptosis has been identified as a promising approach for the development of cancer therapies. Monounsaturated fatty acid (MUFA) is a type of lipid that plays a crucial role in inhibiting ferropto...
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Article
Two-dimensional porous carbon derived from pollen with enlarged interlayer distance enhanced electrocatalytic oxidation of n-valeraldehyde to octane
Electrocatalytic n-valeraldehyde oxidation reaction was an inexpensive and eco-friendly method to control n-valeraldehyde contamination and produce high value-added octane. However, low-cost and readily available...
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Article
Key factors controlling nitrogen transformation and efflux at the sediment–water interface: a comparative study from different trophic reservoirs
Dam construction can impact nitrogen accumulation in reservoir sediments and may potentially lead to internal release due to intricate nitrogen cycling at the sediment–water interface (SWI), exacerbating nitro...
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Article
Creating a zero amylose barley with high soluble sugar content by genome editing
Amylose biosynthesis is strictly associated with granule-bound starch synthase I (GBSSI) encoded by the Waxy gene. Mutagenesis of single bases in the Waxy gene, which induced by CRISPR/Cas9 genome editing, caused...
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Article
Reduction of Typical Antibiotic Resistance Genes and Mobile Gene Elements in Sewage Sludge During Sludge Bioleaching with Acidithiobacillus ferrooxidans
Sewage sludge was considered a critical reservoir for the propagation of antibiotic resistance genes (ARGs) and its treatment and disposal were important for the environment and human health. This study invest...
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Article
Highly selective photocatalytic oxidation of methane to methyl hydroperoxide
Partial oxidation of methane into primary oxidation products with high value remains a challenge. In this work, photocatalytic oxidation of methane (CH4) with high methyl hydroperoxide (CH3OOH) selectivity is ach...
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Article
Virtual Planning and Patient-Specific Graft Design for Aortic Repairs
Patients presenting with coarctation of the aorta (CoA) may also suffer from co-existing transverse arch hypoplasia (TAH). Depending on the risks associated with the surgery and the severity of TAH, clinicians...
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Article
Open AccessStructural insights into the mechanism of protein transport by the Type 9 Secretion System translocon
Secretion systems are protein export machines that enable bacteria to exploit their environment through the release of protein effectors. The Type 9 Secretion System (T9SS) is responsible for protein export ac...
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Article
A Non-uniform Equivalent Model for Free Vibration Analysis of Sandwich Composite Panels with Trapezoidal Lattice Core
Free vibration characteristics of the trapezoidal lattice sandwich composite panels are investigated based on a novel equivalent plate model.
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Article
Open AccessRandomized controlled trial study of intelligent rehabilitation training system for functional ankle instability
To investigate the intervention effect of an intelligent rehabilitation training system on patients with functional ankle instability (FAI) and to advance the research to optimise the effect of FAI rehabilitat...
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Article
Open AccessProspective learning curve analysis of en bloc resection of bladder tumor using an ex vivo porcine model
As a relatively new surgical technique, the learning curve of en bloc resection of bladder tumor (ERBT) in ex vivo models remains unaddressed. This study aimed to explore the learning curve of ERBT in an ex vivo ...
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Article
Open AccessIdentification and verification of a prognostic autophagy-related gene signature in hepatocellular carcinoma
This study aimed to investigate the potential of autophagy-related genes (ATGs) as a prognostic signature for HCC and explore their relationships with immune cells and immune checkpoint molecules. A total of 4...
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Article
Open AccessTuning oxidant and antioxidant activities of ceria by anchoring copper single-site for antibacterial application
The reaction system of hydrogen peroxide (H2O2) catalyzed by nanozyme has a broad prospect in antibacterial treatment. However, the complex catalytic activities of nanozymes lead to multiple pathways reacting in ...
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Article
Open AccessPersonalized neoantigen vaccine enhances the therapeutic efficacy of bevacizumab and anti-PD-1 antibody in advanced non-small cell lung cancer
Clinically, a considerable number of non-small cell lung cancer (NSCLC) patients are unable to receive or resist chemotherapy, and the efficacy of non-chemotherapy treatment strategies based on anti-angiogenic...
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Article
Automatic portals layout for VR navigation
Portals layout in a large virtual scene can help users improve navigation efficiency, but determining the number and the positions of the portals has some challenges. In this paper, we propose two automatic vi...
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Article
Open AccessProteomics-driven noninvasive screening of circulating serum protein panels for the early diagnosis of hepatocellular carcinoma
Early diagnosis of hepatocellular carcinoma (HCC) lacks highly sensitive and specific protein biomarkers. Here, we describe a staged mass spectrometry (MS)-based discovery-verification-validation proteomics wo...
