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Article
Open AccessChitinases as a potential diagnostic and prognostic biomarker for amyotrophic lateral sclerosis: a systematic review and meta-analysis
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the degeneration of motor neurons, and there is currently a lack of reliable diagnostic biomarkers. This meta-analysis ...
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Article
Sha** future workers in China’s secondary vocational schools — a person-centered study on professional identity and career adaptability
Career adaptability is an important psychological resource to measure the career development of secondary vocational school students, and it has an obvious relationship with the antecedent variables such as pr...
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Article
An Hsp70 promoter–based mouse for heat shock–induced gene modulation
Physical therapy is extensively employed in clinical settings. Nevertheless, the absence of suitable animal models has resulted in an incomplete understanding of the in vivo mechanisms and cellular distributio...
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Article
Open AccessIdentification of Hub Genes in Liver Hepatocellular Carcinoma Based on Weighted Gene Co-expression Network Analysis
Liver hepatocellular carcinoma (LIHC) is a malignant cancer with high incidence and poor prognosis. To investigate the correlation between hub genes and progression of LIHC and to provided potential prognostic...
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Article
Characterization of individual spores of two biological insecticides, Bacillus thuringiensis and Lysinibacillus sphaericus, in response to glutaraldehyde using single-cell optical approaches
Bacillus thuringiensis (Bt) and Lysinibacillus sphaericus (Ls) are the most widely used microbial insecticides. Both encounter unfavorable environmental factors and pesticides in the field. Here, the responses of...
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Article
Open AccessAuthor Correction: NIPBL-mediated RAD21 facilitates tumorigenicity by the PI3K pathway in non-small-cell lung cancer
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Article
Open AccessEpitaxy of wafer-scale single-crystal MoS2 monolayer via buffer layer control
Monolayer molybdenum disulfide (MoS2), an emergent two-dimensional (2D) semiconductor, holds great promise for transcending the fundamental limits of silicon electronics and continue the downscaling of field-effe...
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Article
Open AccessNIPBL-mediated RAD21 facilitates tumorigenicity by the PI3K pathway in non-small-cell lung cancer
It is urgent to identify novel early diagnostic markers and therapeutic targets for non-small-cell lung cancer (NSCLC), which accounts for 85% of lung cancer cases and has a 5-year survival rate of 4–17%. Here...
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Article
Open AccessCortical thickness and white matter microstructure predict freezing of gait development in Parkinson’s disease
The clinical applications of the association of cortical thickness and white matter fiber with freezing of gait (FoG) are limited in patients with Parkinson’s disease (PD). In this retrospective study, using w...
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Article
Open AccessAnti-VEGFR2 F(ab′)2 drug conjugate promotes renal accumulation and glomerular repair in diabetic nephropathy
Poor renal distribution of antibody-based drugs is the key factor contributing to low treatment efficiency for renal diseases and side effects. Here, we prepare F(ab′)2 fragmented vascular endothelial growth fact...
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Article
Open AccessApplications of lung cancer organoids in precision medicine: from bench to bedside
As the leading cause of cancer-related mortality, lung cancer continues to pose a menacing threat to human health worldwide. Lung cancer treatment options primarily rely on chemoradiotherapy, surgery, targeted...
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Article
Cytokine storm and translating IL-6 biology into effective treatments for COVID-19
As of May 3, 2023, the Coronavirus disease 2019 (COVID-19) pandemic has resulted in more than 760 million confirmed cases and over 6.9 million deaths. Several patients have developed pneumonia, which can deter...
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Article
Open AccessAbnormal grey matter structural changes in patients with end-stage kidney disease and mild cognitive impairment: correlations with clinical features
End-stage kidney disease and mild cognitive impairment (ESKD-MCI) affect the quality of life and long-term treatment outcomes of patients affected by these diseases. Clarifying the morphological changes from b...
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Article
Abnormal white matter along fibers by automated fiber quantification in patients undergoing hemodialysis
Abnormal white matter has been reported in patients with end-stage renal disease (ESRD). However, few studies have investigated the relationship between specific damage segments and cognition in ESRD. This stu...
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Article
Open AccessApplication of tip-bendable ureteral access sheath in flexible ureteroscopic lithotripsy: an initial experience of 224 cases
During the last decades, the advent of flexible ureteroscopic lithotripsy has revolutionized the management of upper urinary tract stones. We designed a patented tip-bendable ureteral access sheath to facilita...
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Article
Evaluation of the effective elastic properties of periodic nanofiber composites with surface effect using eigenfunction expansion-variational method
The effective elastic properties of composites with double periodic nanofibers are studied theoretically. Based on the Gurtin–Murdoch surface elasticity theory, the elastic field in the nanocomposite can be ex...
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Article
Depression and anxiety among hemophilia patients enrolled in clinical trials: a multi-center cohort study
Hemophilia patients enrolled in clinical trials often exhibit various physical and psychological symptoms. However, little is known about anxiety and depression among them. This study assessed the effects of d...
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Article
Open AccessMaternal NAT10 orchestrates oocyte meiotic cell-cycle progression and maturation in mice
In mammals, the production of mature oocytes necessitates rigorous regulation of the discontinuous meiotic cell-cycle progression at both the transcriptional and post-transcriptional levels. However, the facto...
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Article
Open AccessDefinitive Endodermal Cells Supply an in vitro Source of Mesenchymal Stem/Stromal Cells
Mesenchymal stem/Stromal cells (MSCs) have great therapeutic potentials, and they have been isolated from various tissues and organs including definitive endoderm (DE) organs, such as the lung, liver and intes...
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Article
Multi-componential metal intercalated graphite hybrids synthesized by co-intercalation polymerization towards high-efficient microwave absorptions
Magnetic expanded graphite (EG) hybrids were synthesized by co-intercalation polymerization of aniline together with transition metal ions. Experimental results show that metal ions (Fe, Co, Ni, and Cu) and ev...
