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Article
Open AccessApplication of citric acid can enhance the accuracy for 13C-urea breath tests in the diagnosis of Helicobacter pylori infection in Chinese patients
Previous published data have confirmed that the addition of a citric acid meal improves the accuracy of the 13C-urea breath test (13C-UBT). However, some studies have suggested that a citric acid test meal may no...
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Article
Open AccessA multi-kingdom collection of 33,804 reference genomes for the human vaginal microbiome
The human vagina harbours diverse microorganisms—bacteria, viruses and fungi—with profound implications for women’s health. Genome-level analysis of the vaginal microbiome across multiple kingdoms remains limi...
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Article
Open AccessLncRNA KIFAP3-5:1 inhibits epithelial-mesenchymal transition of renal tubular cell through PRRX1 in diabetic nephropathy
Long noncoding RNAs play an important role in several pathogenic processes in diabetic nephropathy, but the relationship with epithelial-mesenchymal transition in DN is unclear. Herein, we found that KIFAP3-5:...
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Article
Open AccessBacteriophage defends murine gut from Escherichia coli invasion via mucosal adherence
Bacteriophage are sophisticated cellular parasites that can not only parasitize bacteria but are increasingly recognized for their direct interactions with mammalian hosts. Phage adherence to mucus is known to...
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Article
Aldehyde oxidase mediated enantioselective metabolic health risk of dinotefuran
Chiral pollutants often pose significant differential environmental health risks. In this study, the biotransformation of chiral dinotefuran (DIN) and its enantioselective metabolic toxicity mechanisms have be...
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Article
Open AccessAssociation of smart elderly care and quality of life among older adults: the mediating role of social support
In the current context of ageing, the field of smart elderly care has gradually developed, contributing to the promotion of health among older adults. While the positive impact on health has been established, ...
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Article
Open AccessAssociation between incorrect postures and curve magnitude of adolescent idiopathic scoliosis in china
Despite advancements in school scoliosis screening (SSS), there are still no effective indicators to estimate the severity of spinal curvature. We aim to investigate the association between incorrect postures ...
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Article
“RNSP (Rannasangpei)” Rescued MK-801-induced Schizophrenia-like Behaviors in Mice via Oxidative Stress and BDNF-TrkB/Akt Pathway
Schizophrenia (SCZ) is a complex, severe psychotic disorder that is highly persistent. Patients often cannot control their emotions and have delusions of victimization, world-weariness, and even suicide. There...
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Article
Open AccessGenomic landscape and distinct molecular subtypes of primary testicular lymphoma
Primary testicular lymphoma (PTL) is a rare lymphoma predominantly occurring in the elderly male population. It is characterized by a limited response to treatment and a heightened tendency towards relapse. Hi...
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Article
High keratin 15 expression reflects favorable prognosis in early cervical cancer patients
Keratin 15 (KRT15) exhibits inconsistent prognostic roles in different cancers, and its prognostic value in early cervical cancer patients who receive tumor resection remains unknown. This study aimed to asses...
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Open AccessOct4 activates IL-17A to orchestrate M2 macrophage polarization and cervical cancer metastasis
Cervical cancer is a common malignant tumor in the female. Interleukin (IL)-17A is a proinflammatory factor and exerts a vital function in inflammatory diseases and cancers. M2 macrophage has been confirmed to...
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Article
Open AccessChidamide and orelabrutinib synergistically induce cell cycle arrest and apoptosis in diffuse large B-cell lymphoma by regulating the PI3K/AKT/mTOR pathway
The initial therapeutic approach for diffuse large B-cell lymphoma (DLBCL) entails a rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) regimen. However, 40% of patients exhibit sub...
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Article
CF-lines: a fusing contour features optimization method for line segment detector
Aiming at the problem that the existing line segment detectors will detect overdense meaningless textures, this paper proposes a fusing contour features optimization method for line segment detector, called CF...
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Article
Open AccessAssociation between high-density lipoprotein cholesterol and lumbar bone mineral density in Chinese: a large cross-sectional study
The association between lipid and bone metabolism, particularly the role of high-density lipoprotein cholesterol (HDL-C) in regulating bone mineral density (BMD), is of significant interest. Despite numerous s...
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Article
Open AccessTargeting HDACs for diffuse large B-cell lymphoma therapy
Histone deacetylases (HDACs) are involved in tumorigenesis and progression, however, their role in diffuse large B-cell lymphoma (DLBCL) is not well understood. In this study, we examined the expression levels...
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Article
Open AccessTRAF6 triggers Mycobacterium-infected host autophagy through Rab7 ubiquitination
Tumor necrosis factor receptor-associated factor 6 (TRAF6) is an E3 ubiquitin ligase that is extensively involved in the autophagy process by interacting with diverse autophagy initiation and autophagosome mat...
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Article
Open AccessAssociation between total cholesterol and lumbar bone density in Chinese: a study of physical examination data from 2018 to 2023
The impact of total cholesterol (TC) on lumbar bone mineral density (BMD) is a topic of interest. However, empirical evidence on this association from demographic surveys conducted in China is lacking. Therefo...
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Article
Open AccessHydrolase mimic via second coordination sphere engineering in metal-organic frameworks for environmental remediation
Enzymes achieve high catalytic activity with their elaborate arrangements of amino acid residues in confined optimized spaces. Nevertheless, when exposed to complicated environmental implementation scenarios, ...
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Article
Open AccessComparison of miRNA transcriptome of exosomes in three categories of somatic cells with derived iPSCs
Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) through epigenetic manipulation. While the essential role of miRNA in reprogramming and maintaining pluripotency is well studied, l...
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Open AccessCorrection: High homocysteine is associated with idiopathic normal pressure hydrocephalus in deep perforating arteriopathy: a cross-sectional study
