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  1. No Access

    Article

    ETV6 dependency in Ewing sarcoma by antagonism of EWS-FLI1-mediated enhancer activation

    The EWS-FLI1 fusion oncoprotein deregulates transcription to initiate the paediatric cancer Ewing sarcoma. Here we used a domain-focused CRISPR screen to implicate the transcriptional repressor ETV6 as a uniqu...

    Yuan Gao, Xue-Yan He, **aoli S. Wu, Yu-Han Huang, Shushan Toneyan… in Nature Cell Biology (2023)

  2. No Access

    Article

    A pliable ERα cistrome evades therapy

    The transcription factor oestrogen receptor alpha (ERα) has long been targeted for therapeutic benefit in cancer, but drug resistance can emerge through a multitude of mechanisms. A study now reveals how the E...

    **aoli S. Wu, Christopher R. Vakoc in Nature Cell Biology (2020)

  3. No Access

    Article

    Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma

    Core regulatory transcription factors (CR TFs) orchestrate the placement of super-enhancers (SEs) to activate transcription of cell-identity specifying gene networks, and are critical in promoting cancer. Here...

    Berkley E. Gryder, Silvia Pomella, Carly Sayers, **aoli S. Wu… in Nature Genetics (2019)