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Article
Understanding the Causal Relationships Between Opioid Dependence and Risk of Mental Disorders: A Comprehensive Two-Sample Mendelian Randomization Study
Observational studies have reported positive associations between opioid dependence and major mental disorders. However, the causal relationships and causal mechanisms between opioid dependence and mental diso...
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Article
Open AccessMean compression ratio of a self-expandable valve is associated with the need for pacemaker implantation after transcatheter aortic valve replacement
The risk and timing of permanent pacemaker implantation (PPMI) after transcatheter aortic valve replacement (TAVR) is still hard to predict. We aimed to analyze the relationship between the compression ratio o...
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Article
Open AccessPECSS: Pulmonary Embolism Comprehensive Screening Score to safely rule out pulmonary embolism among suspected patients presenting to emergency department
Pulmonary embolism is a severe cardiovascular disease and can be life-threatening if left untreated. However, the detection rate of pulmonary embolism using existing pretest probability scores remained relativ...
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Article
Open AccessA prediction model for permanent pacemaker implantation after transcatheter aortic valve replacement
This study aims to develop a post-procedural risk prediction model for permanent pacemaker implantation (PPMI) in patients treated with transcatheter aortic valve replacement (TAVR).
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Article
Open AccessThe influence of congenital and developmental cataract surgery on the ocular surface in a six-month follow-up prospective clinical study
The purpose of this study was to identify changes in tear film function and meibomian gland function in children after congenital/developmental cataract surgery.
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Article
Open AccessStatus of higher TGF-β1 and TGF-β2 levels in the aqueous humour of patients with diabetes and cataracts
Transforming growth factor (TGF) is a cytokine that acts on the proliferation, migration, differentiation, and apoptosis of cells and the accumulation of extracellular matrix components. Very few studies have ...
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Article
Open AccessAnalysis of multivariate longitudinal substance use outcomes using multivariate mixed cumulative logit model
Longitudinal assessments of usage are often conducted for multiple substances (e.g., cigarettes, alcohol and marijuana) and research interests are often focused on the inter-substance association. We propose a...
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Article
Seizures in steroid-responsive encephalopathy
Steroid-responsive encephalopathy is a general term for diseases that are characterized by diffuse brain injury and respond well to corticosteroids or immunosuppressive agents, including Hashimoto’s encephalop...
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Article
Mixed location scale hidden Markov model for the analysis of intensive longitudinal data
Hidden Markov models (HMM) presents an attractive analytical framework for capturing the state-switching process for auto-correlated data. These models have been extended to longitudinal data setting where sim...
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Article
Comparison of two intense pulsed light patterns for treating patients with meibomian gland dysfunction
The objective of this was to determine the efficacy of different patterns of intense pulsed light (IPL) therapy in patients with meibomian gland dysfunction (MGD).
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Article
A shared parameter location scale mixed effect model for EMA data subject to informative missing
In this paper, we address the problem of accounting for informative missing in the context of ecological momentary assessment studies (sometimes referred to as intensive longitudinal studies), where each stud...
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Article
Comparison of deep anterior lamellar keratoplasty and penetrating keratoplasty with respect to postoperative corneal sensitivity and tear film function
To investigate tear film function, central and peripheral corneal sensitivity and corneal subbasal nerve morphology in the cornea after deep anterior lamellar keratoplasty (DALK) compared with penetrating kera...