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Article
A Polynomial Approach for Thermoelastic Wave Propagation in Functionally Gradient Material Plates
Functionally gradient material (FGM) in service often experience temperature variations that can affect the propagation characteristics of guided waves. This investigation aims to study the propagation of ther...
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Article
Understanding the Causal Relationships Between Opioid Dependence and Risk of Mental Disorders: A Comprehensive Two-Sample Mendelian Randomization Study
Observational studies have reported positive associations between opioid dependence and major mental disorders. However, the causal relationships and causal mechanisms between opioid dependence and mental diso...
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Article
Open AccessMean compression ratio of a self-expandable valve is associated with the need for pacemaker implantation after transcatheter aortic valve replacement
The risk and timing of permanent pacemaker implantation (PPMI) after transcatheter aortic valve replacement (TAVR) is still hard to predict. We aimed to analyze the relationship between the compression ratio o...
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Article
CCDC146 is required for sperm flagellum biogenesis and male fertility in mice
Multiple morphological abnormalities of the flagella (MMAF) is a severe disease of male infertility, while the pathogenetic mechanisms of MMAF are still incompletely understood. Previously, we found that the d...
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Article
Open AccessGSDMD knockdown attenuates phagocytic activity of microglia and exacerbates seizure susceptibility in TLE mice
Temporal lobe epilepsy (TLE) is often characterized pathologically by severe neuronal loss in the hippocampus. Phagocytic activity of microglia is essential for clearing apoptotic neuronal debris, allowing for...
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Article
Open AccessPECSS: Pulmonary Embolism Comprehensive Screening Score to safely rule out pulmonary embolism among suspected patients presenting to emergency department
Pulmonary embolism is a severe cardiovascular disease and can be life-threatening if left untreated. However, the detection rate of pulmonary embolism using existing pretest probability scores remained relativ...
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Article
Open AccessA prediction model for permanent pacemaker implantation after transcatheter aortic valve replacement
This study aims to develop a post-procedural risk prediction model for permanent pacemaker implantation (PPMI) in patients treated with transcatheter aortic valve replacement (TAVR).
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Article
Open AccessTransient neuroinflammation following surgery contributes to long-lasting cognitive decline in elderly rats via dysfunction of synaptic NMDA receptor
Perioperative neurocognitive disorders (PNDs) are considered the most common postoperative complication in geriatric patients. However, its pathogenesis is not fully understood. Surgery-triggered neuroinflamma...
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Article
Open AccessGPR120 modulates epileptic seizure and neuroinflammation mediated by NLRP3 inflammasome
The complex pathophysiology of epilepsy hampers the development of effective treatments. Although more than ten kinds of anti-seizures drugs (ASDs) have good effects on seizure control worldwide, about 30% of ...
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Article
Open AccessThe influence of congenital and developmental cataract surgery on the ocular surface in a six-month follow-up prospective clinical study
The purpose of this study was to identify changes in tear film function and meibomian gland function in children after congenital/developmental cataract surgery.
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Article
Open AccessStatus of higher TGF-β1 and TGF-β2 levels in the aqueous humour of patients with diabetes and cataracts
Transforming growth factor (TGF) is a cytokine that acts on the proliferation, migration, differentiation, and apoptosis of cells and the accumulation of extracellular matrix components. Very few studies have ...
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Article
Open AccessAnalysis of multivariate longitudinal substance use outcomes using multivariate mixed cumulative logit model
Longitudinal assessments of usage are often conducted for multiple substances (e.g., cigarettes, alcohol and marijuana) and research interests are often focused on the inter-substance association. We propose a...
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Article
Effects of pre-imidization on rheological behaviors of polyamic acid solution and thermal mechanical properties of polyimide film: an experiment and molecular dynamics simulation
A series of polyamic acid (PAA) solutions and corresponding polyimide (PI) films with different chemical structures were prepared through a partial pre-imidization process, and the rheological behavior of PAA ...
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Article
Open AccessIntestinal Klebsiella pneumoniae infection enhances susceptibility to epileptic seizure which can be reduced by microglia activation
Epilepsy is a common nervous system disease, and the existing theory does not fully clarify its pathogenesis. Recent research suggests that intestinal microbes may be involved in the development of epilepsy, b...
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Article
Seizures in steroid-responsive encephalopathy
Steroid-responsive encephalopathy is a general term for diseases that are characterized by diffuse brain injury and respond well to corticosteroids or immunosuppressive agents, including Hashimoto’s encephalop...
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Article
Mixed location scale hidden Markov model for the analysis of intensive longitudinal data
Hidden Markov models (HMM) presents an attractive analytical framework for capturing the state-switching process for auto-correlated data. These models have been extended to longitudinal data setting where sim...
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Article
Comparison of two intense pulsed light patterns for treating patients with meibomian gland dysfunction
The objective of this was to determine the efficacy of different patterns of intense pulsed light (IPL) therapy in patients with meibomian gland dysfunction (MGD).
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Article
A shared parameter location scale mixed effect model for EMA data subject to informative missing
In this paper, we address the problem of accounting for informative missing in the context of ecological momentary assessment studies (sometimes referred to as intensive longitudinal studies), where each stud...
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Article
Comparison of deep anterior lamellar keratoplasty and penetrating keratoplasty with respect to postoperative corneal sensitivity and tear film function
To investigate tear film function, central and peripheral corneal sensitivity and corneal subbasal nerve morphology in the cornea after deep anterior lamellar keratoplasty (DALK) compared with penetrating kera...
