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Article
Open AccessA chromosome-level genome assembly and annotation of the medicinal plant Lepidium apetalum
As a traditional Chinese medicine, Lepidium apetalum is commonly used for purging the lung, relieving dyspnea, alleviating edema, and has the significant pharmacological effects on cardiovascular disease, hyperli...
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Chapter and Conference Paper
English and Spanish Bilinguals’ Language Processing: An ALE-Based Meta-analysis of Neuroimaging Studies
The neural mechanisms underlying language processing in English and Spanish bilinguals remain a topic of intense investigation. No neuroimaging meta-analyses about English and Spanish bilinguals’ language proc...
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Article
Open AccessCharacteristics and mechanisms of mosaicism in prenatal diagnosis cases by application of SNP array
With the application of chromosome microarray, next-generation sequencing and other highly sensitive genetic techniques in disease diagnosis, the detection of mosaicism has become increasingly prevalent. This ...
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Article
Open AccessIntegrated bioinformatics analysis for identifying key genes and pathways in female and male patients with dilated cardiomyopathy
Dilated cardiomyopathy (DCM) is a common cause of heart failure, and males are more likely to suffer from DCM than females. This research aimed at exploring possible DCM-associated genes and their latent regul...
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Article
Four New Phenolic Glycosides from the Seeds of Lepidium apetalum
Four new phenolic glycosides lepidiumosides A–D (1–4) were isolated from the water extract of the seeds of Lepidium apetalum Willd. Their structures were determined by extensive spectroscopic (UV, IR, HR-ESI-MS, ...
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Article
Acacetin inhibits myocardial mitochondrial dysfunction by activating PI3K/AKT in SHR rats fed with fructose
To explore the effect of acacetin on myocardial mitochondrial dysfunction in spontaneously hypertensive rats (SHR) with insulin resistance (IR), and the possible mechanism. Rapid IR was first induced in fructo...
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Article
Diagnostic efficacy and influence factors of urinary protein/creatinine ratio replacing 24-h urine protein as an evaluator of proteinuria in children
The aim was to investigate the diagnostic efficacy of urinary protein/creatinine ratio (UPCR) and factors influencing its substitutability of 24-h urine protein (24hUP) in children with proteinuria.
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Article
Open AccessExtract of Corallodiscus flabellata attenuates renal fibrosis in SAMP8 mice via the Wnt/β-catenin/RAS signaling pathway
Fibrosis is one of the most common pathological features of the aging process of the kidney, and fibrosis in aging kidneys also aggravates the process of chronic kidney disease (CKD). Corallodiscus flabellata B. ...
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Article
Amentoflavone Ameliorates Memory Deficits and Abnormal Autophagy in Aβ25−35-Induced Mice by mTOR Signaling
Alzheimer’s disease (AD) is a neurodegenerative disease in which autophagy plays a crucial role. Amentoflavone is a flavonoid obtained from various plants and has been shown to have AD-resistant neuroprotectiv...
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Article
Open AccessPrenatal diagnosis of 7 cases with uniparental disomy by utilization of single nucleotide polymorphism array
The phenotypes of uniparental disomy (UPD) are variable, which may either have no clinical impact, lead to clinical signs and symptoms. Molecular analysis is essential for making a correct diagnosis. This stud...
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Article
Open AccessElectrochemiluminescence immunosensor for cytokeratin fragment antigen 21-1 detection using electrochemically mediated atom transfer radical polymerization
The cytokeratin fragment antigen 21-1 (CYFRA 21-1) protein is a critical tumor biomarker tightly related to non-small cell lung cancer (NSCLC). Herein, we prepared an effective electrochemiluminescence (ECL) i...
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Article
Open AccessAcacetin improves endothelial dysfunction and aortic fibrosis in insulin-resistant SHR rats by estrogen receptors
The aim of the work was to investigate the effects of acacetin on endothelial dysfunction and aortic fibrosis in insulin-resistant SHR rats and explore its mechanism. Seven-week-old male spontaneously hyperten...
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Article
Open Access3D Printing of Well Dispersed Electrospun PLGA Fiber Toughened Calcium Phosphate Scaffolds for Osteoanagenesis
Although the toughening of Calcium phosphate (CaP) scaffold by the addition of fiber has been well recognized, integrated mechanical, structural and functional considerations have been neglected in the design ...
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Article
Open AccessMolecular delineation of small supernumerary marker chromosomes using a single nucleotide polymorphism array
Defining the phenotype-genotype correlation of small supernumerary marker chromosomes (sSMCs) remains a challenge in prenatal diagnosis. We karyotyped 20,481 amniotic fluid samples from pregnant women and expl...
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Article
A novel bi-modal probe based on BaHoF5 and Cu-doped QDs with enhanced CT contrast efficiency and fluorescent brightness for tumor-targeting imaging
In this work, a novel bi-modal imaging probe with enhanced CT contrast efficiency and FL brightness was constructed, in which the combination of a binary CT contrast agent BaHoF5 and Cu-doped QDs served as a vehi...
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Article
A Novel N Staging System for Predicting Survival in Patients with Medullary Thyroid Cancer
Despite the crucially prognostic value of lymph node metastasis (LNM) in patients with medullary thyroid cancer (MTC), only the LNM compartment alone was reflected in the 8th edition of the American Joint Comm...
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Article
Open AccessThe protective effect and mechanism of catalpol on high glucose-induced podocyte injury
Catalpol, a natural iridoid glycoside in Rehmannia glutinosa, can alleviate proteinuria associated with diabetic nephropathy (DN), however, whether catalpol has a protective effect against podocyte injury in DN r...
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Article
Synthesis of visible light-driven graphene based ZnFe mixed metal oxide for efficient degradation of tetracycline
Magnetically separable reduced graphene oxide (RGO)-based ZnFe mixed metal oxide (MMO) nanocomposite (MMO/RGO) was prepared via a scalable and low energy-consuming co-precipitation-calcination process. The pre...
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Article
A carnation-like rGO/Bi2O2CO3/BiOCl composite: efficient photocatalyst for the degradation of ciprofloxacin
A ternary reduced graphene oxide based Bi2O2CO3/BiOCl (rBB) composite was prepared for the first time via a facile hydrothermal approach. The composite has a carnation-like morphology and consists of self-assembl...
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Article
Porous Co3O4 nanosheets as a high-performance non-enzymatic sensor for glucose detection
Novel porous Co3O4 nanosheets (NSs) were synthesized on the flexible carbon cloth (CC) substrate by a facile hydrothermal method and applied to construct a non-enzymatic sensor for glucose detection. The sensor i...
