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Article
Open AccessTargeting HIC1/TGF-β axis-shaped prostate cancer microenvironment restrains its progression
Prostate cancer (PCa) is a malignant tumor that seriously threatens men’s health worldwide. Recently, stromal cells in the tumor microenvironment (TME) have been reported to contribute to the progression of PC...
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Article
Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression
Prostate cancer shows remarkable clinical heterogeneity, which manifests in spatial and clonal genomic diversity. By contrast, the transcriptomic heterogeneity of prostate tumours is poorly understood. Here we...
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Article
Open AccessLINC00675 activates androgen receptor axis signaling pathway to promote castration-resistant prostate cancer progression
The development of prostate cancer (PCa) from androgen-deprivation therapy (ADT) sensitive to castration resistant (CRPC) seriously impacts life quality and survival of PCa patients. Emerging evidence shows th...
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Article
Open AccessMicrovesicles and chemokines in tumor microenvironment: mediators of intercellular communications in tumor progression
Increasing evidence indicates that the ability of cancer cells to convey biological information to recipient cells within the tumor microenvironment (TME) is crucial for tumor progression. Microvesicles (MVs) ...
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Article
Open AccessTNF-α sensitizes chemotherapy and radiotherapy against breast cancer cells
Despite new developments in cancer therapy, chemotherapy and radiotherapy remain the cornerstone of breast cancer treatment. Therefore, finding ways to reduce the toxicity and increase sensitivity is particula...
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Article
The effect and side effects of Gemcitabine plus Vinorelbine in patients with triple-negative metastatic breast cancer
The aim of this study was to evaluate the anti-tumor activity and safety of Gemcitabine (GEM) combined with Vinorelbine (NVB) in patients with advanced TNABC after chemotherapy.
