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Article
O2ath: an OpenMP offloading toolkit for the sunway heterogeneous manycore platform
The next generation Sunway supercomputer employs the SW26010pro processor, which features a specialized on-chip heterogeneous architecture. Applications with significant hotspots can benefit from the great com...
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Article
Cover plant functional types alter the abundance and composition of hydrophobic compounds: The relationship with soil water repellency on the Chinese Loess Plateau
It is widely accepted that soil water repellency (SWR) is mainly caused by hydrophobic compounds from plants and microbes. The relation between these hydrophobic compounds, which are defined as SWR biomarkers,...
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Article
Open AccessDeep medullary vein damage correlates with small vessel disease in small vessel occlusion acute ischemic stroke
We aim to investigate whether cerebral small vessel disease (cSVD) imaging markers correlate with deep medullary vein (DMV) damage in small vessel occlusion acute ischemic stroke (SVO-AIS) patients.
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Article
Celastrol ameliorates energy metabolism dysfunction of hypertensive rats by dilating vessels to improve hemodynamics
The impact of hypertension on tissue and organ damage is mediated through its influence on the structure and function of blood vessels. This study aimed to examine the potential of celastrol, a bioactive compo...
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Article
Open AccessNucleotide excision repair deficiency is a targetable therapeutic vulnerability in clear cell renal cell carcinoma
Due to a demonstrated lack of DNA repair deficiencies, clear cell renal cell carcinoma (ccRCC) has not benefitted from targeted synthetic lethality-based therapies. We investigated whether nucleotide excision ...
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Article
Open AccessCirculating cell-free DNA fragmentation is a stepwise and conserved process linked to apoptosis
Circulating cell-free DNA (cfDNA) is a pool of short DNA fragments mainly released from apoptotic hematopoietic cells. Nevertheless, the precise physiological process governing the DNA fragmentation and molecu...
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Article
Open AccessEnhanced radiosensitivity and chemoradiation efficacy in nasopharyngeal carcinoma via a dual-targeted SPION@polymer hybrid nanosensitizer
Cisplatin-based nanoparticles show good potential in enhancing the effect of nasopharynx carcinoma (NPC) therapy but are still limited by their low radiation sensitization and poor tumor targeting ability. Her...
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Article
Open AccessTowards practical and massively parallel quantum computing emulation for quantum chemistry
Quantum computing is moving beyond its early stage and seeking for commercial applications in chemical and biomedical sciences. In the current noisy intermediate-scale quantum computing era, the quantum resour...
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Article
Correction to: Castor1 overexpression regulates microglia M1/M2 polarization via inhibiting mTOR pathway
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Article
Collateral-Core Ratio as a Novel Predictor of Clinical Outcomes in Acute Ischemic Stroke
The interaction effect between collateral circulation and ischemic core size on stroke outcomes has been highlighted in acute ischemic stroke (AIS). However, biomarkers that assess the magnitude of this intera...
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Article
Castor1 overexpression regulates microglia M1/M2 polarization via inhibiting mTOR pathway
Microglia are resident immune cells in the brain and are closely associated with central nervous system inflammation and neurodegenerative diseases. It is known that mammalian target of rapamycin (mTOR) pathwa...
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Article
Manganese-doped mesoporous polydopamine nanoagent for T1–T2 magnetic resonance imaging and tumor therapy
Theranostic nanodrugs combining magnetic resonance imaging (MRI) and cancer therapy have attracted extensive interest in cancer diagnosis and treatment. Herein, a manganese (Mn)-doped mesoporous polydopamine (...
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Chapter and Conference Paper
Electric Field Simulation and Optimization of Environmentally Friendly ±400 kV DC Wall Bushing
SF6 is still widely used as insulation medium for DC wall bushing, although it possesses strong greenhouse effect. C4F7N/CO2 mixture gas has attracted attention as a potential SF6 alternative gas. In this paper, ...
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Article
Open AccessPsychological stress induces depressive-like behavior associated with bone marrow-derived monocyte infiltration into the hippocampus independent of blood–brain barrier disruption
Psychological stress is one of the most important factors that trigger emotional disorders, such as depression and anxiety. Emerging evidence suggests that neuroinflammation exacerbated by bidirectional commun...
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Article
Accelerating susceptibility-weighted imaging with deep learning by complex-valued convolutional neural network (ComplexNet): validation in clinical brain imaging
Susceptibility-weighted imaging (SWI) is crucial for the characterization of intracranial hemorrhage and mineralization, but has the drawback of long acquisition times. We aimed to propose a deep learning mode...
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Article
Open AccessMorphologic CT and MRI features of primary parotid squamous cell carcinoma and its predictive factors for differential diagnosis with mucoepidermoid carcinoma
Primary parotid squamous cell carcinoma (SCC) is a rare entity with a poor prognosis. Pathologically, the diagnosis of it requires the exclusion of parotid mucoepidermoid carcinoma (MEC). Currently, the imagin...
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Article
Non-clinical immunogenicity, biodistribution and toxicology evaluation of a chimpanzee adenovirus-based COVID-19 vaccine in rat and rhesus macaque
Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in 2019 has rapidly expanded into a serious global pandemic. Due to the high morbidity and mor...
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Article
Automatic system for high-throughput and high-sensitivity diagnosis of SARS-CoV-2
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had severe consequences for health and the global economy. To control the transmissio...
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Chapter and Conference Paper
A Study on the Generalized Normalization Transformation Activation Function in Deep Learning Based Image Compression
compression has a long history, being widely applied in numerous applications. Yet, the commonly applied approach is based on traditional signal processing, such as JPEG. The lack of lea...
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Chapter and Conference Paper
System Design Based on the Dynamic Simulation Platform of Urban Rail Transit Traction Power Supply
In the initial construction and scientific research activities of urban rail transit, there are high requirements for the management analysis and use of train line operation data, line parameters, electrical p...
