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  1. No Access

    Article

    HIPK2 suppresses tumor growth and progression of hepatocellular carcinoma through promoting the degradation of HIF-1α

    Aberrant angiogenesis of hepatocellular carcinoma (HCC) leads to tumor growth and local or distant metastasis. Uncovering the underlying mechanisms for the neoangiogenesis of HCC can provide novel potential th...

    Peizhan Chen, **aohua Duan, **aoguang Li, **gquan Li, Qian Ba, Hui Wang in Oncogene (2020)

  2. Article

    Open Access

    A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection

    COVID-19 is a systemic disease involving multiple organs. We previously established a platform to derive organoids and cells from human pluripotent stem cells to model SARS-CoV-2 infection and perform drug scr...

    Xuming Tang, Dongxiang Xue, Tuo Zhang, Benjamin E. Nilsson-Payant… in Nature Cell Biology (2023)

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  3. Article

    Open Access

    Checkpoint kinase 2 controls insulin secretion and glucose homeostasis

    After the discovery of insulin, a century ago, extensive work has been done to unravel the molecular network regulating insulin secretion. Here we performed a chemical screen and identified AZD7762, a compound...

    Angie Chi Nok Chong, J. Jeya Vandana, Ginnie Jeng, Ge Li… in Nature Chemical Biology (2024)

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