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  1. Article

    Open Access

    FAM3A Ameliorates Brain Impairment Induced by Hypoxia–Ischemia in Neonatal Rat

    Hypoxia–ischemia (HI) during crucial periods of brain formation can lead to changes in brain morphology, propagation of neuronal stimuli, and permanent neurodevelopmental impairment, which can have profound ef...

    Qing Song, Qingying Gao, Taotao Chen, Ting Wen in Cellular and Molecular Neurobiology (2023)

  2. Article

    Open Access

    Ameliorating Inflammation in Insulin-resistant Rat Adipose Tissue with Abdominal Massage Regulates SIRT1/NF-κB Signaling

    It was the aim of this study to determine whether abdominal massage reverses high-fat diet-induced insulin resistance compared with RSV treatment. A total of sixty male Sprague-Dawley rats were randomly placed...

    Tianjiao Gao, Shaotao Chen, Yiran Han, Dongmei Zhang in Cell Biochemistry and Biophysics (2022)

  3. Article

    Open Access

    Abdominal Massage Alleviates Skeletal Muscle Insulin Resistance by Regulating the AMPK/SIRT1/PGC-1α Signaling Pathway

    Abdominal massage (AM), a traditional Chinese medicine-based treatment method, has received considerable attention in the recent years. The aim of the present study was to investigate the effect of AM on high-...

    Yiran Han, Zeyuan Lu, Shaotao Chen, Chongwen Zhong in Cell Biochemistry and Biophysics (2021)

  4. No Access

    Article

    Modelling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes

    Human liver cancers, including hepatocellular carcinomas and intra-hepatic cholangiocarcinomas, are often diagnosed late with poor prognosis. A better understanding of cancer initiation could provide potential...

    Lulu Sun, Yuqing Wang, ** Cen, **aolong Ma, Lei Cui, Zhixin Qiu in Nature Cell Biology (2019)

  5. Article

    Erratum: Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin

    Nat. Cell Biol. 14, 1203–1211 (2012); published online 7th October 2012; corrected online 14 March 2013 During the preparation of Fig. 8c, the image of c-Fos staining on non-HCC samples was inadvertantly dupli...

    Lihua Min, Yuan Ji, Latifa Bakiri, Zhixin Qiu, ** Cen, **aotao Chen in Nature Cell Biology (2013)

  6. No Access

    Article

    Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin

    Understanding stage-dependent oncogenic mechanisms is critical to develop not only targeted therapies, but also diagnostic markers and preventive strategies. The mechanisms acting during cancer initiation rema...

    Lihua Min, Yuan Ji, Latifa Bakiri, Zhixin Qiu, ** Cen, **aotao Chen in Nature Cell Biology (2012)

  7. Article

    Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells through promoting the proliferation of cardiac progenitor cells

    Generation of induced pluripotent stem cells (iPSCs) has opened new avenues for the investigation of heart diseases, drug screening and potential autologous cardiac regeneration. However, their application is ...

    Nan Cao, Zumei Liu, Zhongyan Chen, Jia Wang, Taotao Chen, **aoyang Zhao in Cell Research (2012)

  8. Article

    More synergetic cooperation of Yamanaka factors in induced pluripotent stem cells than in embryonic stem cells

    The role of Yamanaka factors as the core regulators in the induction of pluripotency during somatic cell reprogramming has been discovered recently. Our previous study found that Yamanaka factors regulate a de...

    **yan Huang, Taotao Chen, **aosong Liu, **g Jiang, **song Li in Cell Research (2009)

  9. Article

    Yamanaka factors critically regulate the developmental signaling network in mouse embryonic stem cells

    Yamanaka factors (Oct3/4, Sox2, Klf4, c-Myc) are highly expressed in embryonic stem (ES) cells, and their over-expression can induce pluripotency in both mouse and human somatic cells, indicating that these fa...

    **aosong Liu, **yan Huang, Taotao Chen, Ying Wang, Shunmei **n, Jian Li in Cell Research (2008)

  10. Article

    Enhanced efficiency of generating induced pluripotent stem (iPS) cells from human somatic cells by a combination of six transcription factors

    **g Liao, Zhao Wu, Ying Wang, Lu Cheng, Chun Cui, Yuan Gao, Taotao Chen in Cell Research (2008)

  11. Article

    C/EBPαp30 plays transcriptional regulatory roles distinct from C/EBPαp42

    CCAAT/enhancer binding protein α (C/EBPα) is a transcriptional regulatory factor that inhibits cell proliferation, and alternative translational initiation produces two polypeptides, C/EBPαp30 and C/EBPαp42. B...

    Chunxi Wang, **aotao Chen, Yan** Wang, Jialei Gong, Gengxi Hu in Cell Research (2007)