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Open AccessAmeliorating Inflammation in Insulin-resistant Rat Adipose Tissue with Abdominal Massage Regulates SIRT1/NF-κB Signaling
It was the aim of this study to determine whether abdominal massage reverses high-fat diet-induced insulin resistance compared with RSV treatment. A total of sixty male Sprague-Dawley rats were randomly placed...
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Open AccessAbdominal Massage Alleviates Skeletal Muscle Insulin Resistance by Regulating the AMPK/SIRT1/PGC-1α Signaling Pathway
Abdominal massage (AM), a traditional Chinese medicine-based treatment method, has received considerable attention in the recent years. The aim of the present study was to investigate the effect of AM on high-...
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Article
Modelling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes
Human liver cancers, including hepatocellular carcinomas and intra-hepatic cholangiocarcinomas, are often diagnosed late with poor prognosis. A better understanding of cancer initiation could provide potential...
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Erratum: Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin
Nat. Cell Biol. 14, 1203–1211 (2012); published online 7th October 2012; corrected online 14 March 2013 During the preparation of Fig. 8c, the image of c-Fos staining on non-HCC samples was inadvertantly dupli...
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Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin
Understanding stage-dependent oncogenic mechanisms is critical to develop not only targeted therapies, but also diagnostic markers and preventive strategies. The mechanisms acting during cancer initiation rema...
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Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells through promoting the proliferation of cardiac progenitor cells
Generation of induced pluripotent stem cells (iPSCs) has opened new avenues for the investigation of heart diseases, drug screening and potential autologous cardiac regeneration. However, their application is ...
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More synergetic cooperation of Yamanaka factors in induced pluripotent stem cells than in embryonic stem cells
The role of Yamanaka factors as the core regulators in the induction of pluripotency during somatic cell reprogramming has been discovered recently. Our previous study found that Yamanaka factors regulate a de...
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Yamanaka factors critically regulate the developmental signaling network in mouse embryonic stem cells
Yamanaka factors (Oct3/4, Sox2, Klf4, c-Myc) are highly expressed in embryonic stem (ES) cells, and their over-expression can induce pluripotency in both mouse and human somatic cells, indicating that these fa...
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Enhanced efficiency of generating induced pluripotent stem (iPS) cells from human somatic cells by a combination of six transcription factors
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Article
C/EBPαp30 plays transcriptional regulatory roles distinct from C/EBPαp42
CCAAT/enhancer binding protein α (C/EBPα) is a transcriptional regulatory factor that inhibits cell proliferation, and alternative translational initiation produces two polypeptides, C/EBPαp30 and C/EBPαp42. B...