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Article
Open AccessGenetic constraint at single amino acid resolution in protein domains improves missense variant prioritisation and gene discovery
One of the major hurdles in clinical genetics is interpreting the clinical consequences associated with germline missense variants in humans. Recent significant advances have leveraged natural variation observ...
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Article
Visualization of Blood–Brain Barrier Disruption in Septic Mice with the New Method Based on in Vivo Imaging Technology
Dynamic monitoring of the blood–brain barrier (BBB) functional status in septic mice can help to explore the pathological mechanisms. Therefore, we proposed a new method for monitoring BBB permeability and app...
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Article
Open AccessSirenian genomes illuminate the evolution of fully aquatic species within the mammalian superorder afrotheria
Sirenians of the superorder Afrotheria were the first mammals to transition from land to water and are the only herbivorous marine mammals. Here, we generated a chromosome-level dugong (Dugong dugon) genome. A co...
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Article
Radical partial vulvectomy combined with through vulva incision laparoendoscopic single-site inguinal lymphadenectomy for vulva cancer
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Article
20-Deoxyingenol Activates Mitophagy Through TFEB and Promotes Functional Recovery After Spinal Cord Injury
Spinal cord injury (SCI) can lead to permanent paralysis and various motor, sensory and autonomic nervous system dysfunction. The complex pathophysiological processes limit the effectiveness of many clinical t...
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Article
Open AccessThe Mutual Regulatory Role of Ferroptosis and Immunotherapy in Anti-tumor Therapy
Ferroptosis is a form of cell death that is triggered by the presence of ferrous ions and is characterized by lipid peroxidation induced by these ions. The mechanism exhibits distinct morphological characteris...
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Article
Open AccessThe impact of the combat method on radiomics feature compensation and analysis of scanners from different manufacturers
This study investigated whether the Combat compensation method can remove the variability of radiomic features extracted from different scanners, while also examining its impact on the subsequent predictive pe...
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Article
hP-MSCs attenuate severe acute pancreatitis in mice via inhibiting NLRP3 inflammasome-mediated acinar cell pyroptosis
Severe acute pancreatitis (SAP) is a serious gastrointestinal disease that is facilitated by pancreatic acinar cell death. The protective role of human placental mesenchymal stem cells (hP-MSCs) in SAP has bee...
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Article
Open AccessPrognostic impact and immunotherapeutic implications of NETosis-related prognostic model in clear cell renal cell carcinoma
The ramifications of necroptosis on the prognostication of clear cell renal cell carcinoma (ccRCC) remain inadequately expounded.
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Article
Open AccessA multi-view fusion lightweight network for CRSwNPs prediction on CT images
Accurate preoperative differentiation of the chronic rhinosinusitis (CRS) endotype between eosinophilic CRS (eCRS) and non-eosinophilic CRS (non-eCRS) is an important topic in predicting postoperative outcomes...
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Article
Open AccessDeep learning in computed tomography to predict endotype in chronic rhinosinusitis with nasal polyps
As treatment strategies differ according to endotype, rhinologists must accurately determine the endotype in patients affected by chronic rhinosinusitis with nasal polyps (CRSwNP) for the appropriate managemen...
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Chapter and Conference Paper
PmmNDD: Predicting the Pathogenicity of Missense Mutations in Neurodegenerative Diseases via Ensemble Learning
Accurately distinguishing between pathogenic and benign mutations continues to pose a significant challenge in the clinical genetic testing of patients with neurodegenerative diseases (NDDs). In theory, comput...
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Chapter and Conference Paper
Application of Hydrogen Reburning Technology in Low Nitrogen Combustion in 660 MW Coal-Fired Boilers
Coal-fired boilers are one of the main sources of NOx emissions, and controlling the generation and emission of nitrogen oxides is a hot issue of general concern in today’s society. Hydrogen has the characteristi...
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Chapter and Conference Paper
SR-GNN: Spectral Residuals with Graph Neural Networks for Anomaly Detection in ADS-B Data
The Automatic Dependent Surveillance–Broadcast (ADS-B) system is an essential component of the air traffic system. However, its protocol lacks data encryption and authentication, making it highly vulnerable to...
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Article
Inter-laboratory validation by event-specific qPCR methods for the detection of genetically modified insect and herbicide-tolerant maize DBN9501
DBN9501 is a new maize transgenic event characterised by being resistance to insects and herbicides. To meet genetically modified (GM)-labeling requirements and monitor the unintended release of genetically mo...
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Article
A note on a Cohen-type theorem for Artinian modules
In this paper, we prove that a finitely embedded R-module M is Artinian if and only if for every prime ideal \(\mathfrak {p}\) ...
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Article
Open AccessHow can technology leverage university teaching & learning innovation? A longitudinal case study of diffusion of technology innovation from the knowledge creation perspective
This paper expands the innovation diffusion framework by adding a conceptual and empirical exploration of knowledge creation into understanding university technology-enhanced teaching and learning innovation. ...
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Article
Stable buffer couple series for rhizosphere oxidant-reductant potential regulation suitable for rice hydroponic cultivation experiments
Reduction–oxidation potential (Eh) determines element speciation and availability. Establishing rhizosphere surrounding with stable Eh by hydroponics plays an important role in several disciplines. But it’s still...
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Article
A multi-stream network for retrosynthesis prediction
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Article
Open AccessCorrection: Polygenic risk for triglyceride levels in the presence of a high impact rare variant
