28 Result(s)
within
**ao-yu Jia
Life Sciences
-
Article
Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor
Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins, showing a potential threat to humans. Here we report the infectivity and pathogenicity of the SARS-CoV-2-related virus, ...
-
Article
Proteomics Sequencing Reveals the Role of TGF-β Signaling Pathway in the Peripheral Blood of Offspring Rats Exposed to Fluoride
The underlying mechanism of fluorosis has not been fully elucidated. The purpose of this study was to explore the mechanism of fluorosis induced by sodium fluoride (NaF) using proteomics. Six offspring rats ex...
-
Article
Open AccessThrombomodulin reduces α-synuclein generation and ameliorates neuropathology in a mouse model of Parkinson’s disease
The neurotoxic α-synuclein (α-syn) oligomers play an important role in the occurrence and development of Parkinson’s disease (PD), but the factors affecting α-syn generation and neurotoxicity remain unclear. W...
-
Article
Open AccessMulti-modal molecular determinants of clinically relevant osteoporosis subtypes
Due to a rapidly aging global population, osteoporosis and the associated risk of bone fractures have become a wide-spread public health problem. However, osteoporosis is very heterogeneous, and the existing s...
-
Article
Exome sequencing identifies genes associated with sleep-related traits
Sleep is vital for human health and has a moderate heritability. Previous genome-wide association studies have limitations in capturing the role of rare genetic variants in sleep-related traits. Here we conduc...
-
Article
Species diversity, updated classification and divergence times of the phylum Mucoromycota
Zygomycetes are phylogenetically early diverging, ecologically diverse, industrially valuable, agriculturally beneficial, and clinically pathogenic fungi. Although new phyla and subphyla have been constantly e...
-
Article
Identifying modifiable factors and their joint effect on dementia risk in the UK Biobank
Previous hypothesis-driven research has identified many risk factors linked to dementia. However, the multiplicity and co-occurrence of risk factors have been underestimated. Here we analysed data of 344,324 p...
-
Article
Open AccessSubty**-based platform guides precision medicine for heavily pretreated metastatic triple-negative breast cancer: The FUTURE phase II umbrella clinical trial
Triple-negative breast cancer (TNBC) is a heterogeneous disease and lacks effective treatment. Our previous study classified TNBCs into four subtypes with putative therapeutic targets. Here, we report the fina...
-
Article
Open AccessMetavirome of 31 tick species provides a compendium of 1,801 RNA virus genomes
The increasing prevalence and expanding distribution of tick-borne viruses globally have raised health concerns, but the full repertoire of the tick virome has not been assessed. We sequenced the meta-transcri...
-
Article
Open AccessTrafficked Malayan pangolins contain viral pathogens of humans
Pangolins are the most trafficked wild animal in the world according to the World Wildlife Fund. The discovery of SARS-CoV-2-related coronaviruses in Malayan pangolins has piqued interest in the viromes of the...
-
Article
Open AccessThe Kandelia obovata transcription factor KoWRKY40 enhances cold tolerance in transgenic Arabidopsis
WRKY transcription factors play key roles in plant development processes and stress response. Kandelia obovata is the most cold-resistant species of mangrove plants, which are the important contributors to coasta...
-
Article
Correction to: Synthetic antimicrobial agents inhibit aflatoxin production
A Correction to this paper has been published: https://doi.org/10.1007/s42770-021-00501-7
-
Article
Synthetic antimicrobial agents inhibit aflatoxin production
Antimicrobial peptides (AMPs) are biologically active molecules that can eradicate bacteria by destroying the bacterial membrane structure, causing the bacteria to rupture. However, little is known about the e...
-
Article
Open AccessCancer-associated fibroblast-derived CXCL11 modulates hepatocellular carcinoma cell migration and tumor metastasis through the circUBAP2/miR-4756/IFIT1/3 axis
Cancer-associated fibroblasts (CAFs) are commonly acquired activated extracellular matrix (ECM)-producing myofibroblasts, a phenotypes with multiple roles in hepatic fibrogenesis and carcinogenesis via crossta...
-
Article
Intramuscular injection of tetracycline decreased gut microbial diversity in mouse
Antibiotics contribute a lot to human beings and can kill bacteria effectively. However, more and more studies show that antibiotics can disturb the intestinal microbial community. It has been widely reported ...
-
Article
Open AccessThe suppression of apoptosis by α-herpesvirus
Apoptosis, an important innate immune mechanism that eliminates pathogen-infected cells, is primarily triggered by two signalling pathways: the death receptor pathway and the mitochondria-mediated pathway. How...
-
Article
Open AccessT cell infiltration is associated with kidney injury in patients with anti-glomerular basement membrane disease
Cell-mediated autoimmunity, particularly that involving autoreactive T cells, participates in mediating anti-glomerular basement membrane (GBM) disease. However, direct kidney injury mediated by renal infiltra...
-
Article
Development of microsatellite markers for six Tetranychus species by transfer from Tetranychus urticae genome
Microsatellite markers are frequently used to explore the population genetic structure of organisms. Spider mites (genus Tetranychus) are important agricultural pests. Several markers have been developed for T. u...
-
Article
Open AccessComparative genomic analysis identifies structural features of CRISPR-Cas systems in Riemerella anatipestifer
Riemerella anatipestifer infection is a contagious disease that has resulted in major economic losses in the duck industry worldwide. This study attempted to characterize CRISPR-Cas sy...
-
Article
Autotoxicity of the soil of consecutively cultured tea plantations on tea (Camellia sinensis) seedlings
The production and quality of Tie-Guan-Yin tea (Camellia sinensis) decrease with time after continuous picking over multiple years. However, it is unclear how the soils of consecutively cultured tea plantations a...
