1,141 Result(s)
within
**ao-wei Chen
-
Article
Open AccessATP6V0A1-dependent cholesterol absorption in colorectal cancer cells triggers immunosuppressive signaling to inactivate memory CD8+ T cells
Obesity shapes anti-tumor immunity through lipid metabolism; however, the mechanisms underlying how colorectal cancer (CRC) cells utilize lipids to suppress anti-tumor immunity remain unclear. Here, we show th...
-
Article
The ALMaQUEST Survey XV: The dependence of the molecular-to-atomic gas ratios on resolved optical diagnostics
The atomic-to-molecular gas conversion is a critical step in the baryon cycle of galaxies, which sets the initial conditions for subsequent star formation and influences the multi-phase interstellar medium. We...
-
Article
Robotic versus laparoscopic pelvic lateral lymph node dissection in locally advanced rectal cancer: a systemic review and meta-analysis
There are few available studies that compare the feasibility, efficacy, and safety of robotic pelvic lateral lymph node dissection compared to laparoscopic pelvic lateral lymph node dissection (LPLND) in advan...
-
Article
Utilizing procalcitonin, C-reactive protein, and serum amyloid A in combination for diagnosing sepsis due to urinary tract infection
In this study, we aimed to evaluate the combined diagnostic value of procalcitonin (PCT), C-reactive protein (CRP), and serum amyloid A (SAA) in sepsis caused by urinary tract infection.
-
Article
Open AccessExploring the oncogenic potential of circSOD2 in clear cell renal cell carcinoma: a novel positive feedback loop
Existing studies have found that circular RNAs (circRNAs) act as sponges for micro RNAs (miRNAs) to control downstream genes. However, the specific functionalities and mechanisms of circRNAs in human clear cel...
-
Article
Alterations in Serum Lipids and Lipoproteins Induced by Neoadjuvant Chemotherapy in Patients with Osteosarcoma around the Knee Joint: A Retrospective Analysis
To investigate the serum lipid profiles of patients with localized osteosarcoma around the knee joint before and after neoadjuvant chemotherapy.
-
Article
Open AccessSensory ASIC3 channel exacerbates psoriatic inflammation via a neurogenic pathway in female mice
Psoriasis is an immune-mediated skin disease associated with neurogenic inflammation, but the underlying molecular mechanism remains unclear. We demonstrate here that acid-sensing ion channel 3 (ASIC3) exacerb...
-
Article
Mobile phone addiction and emptiness among Chinese college students: the chain mediating role of attention control and self-concept clarity
Although mobile phones can provide temporary sensory pleasure to satisfy people’s psychological needs, prolonged use of mobile phones may lead to unpleasant and even empty feelings. Thus, this study constructe...
-
Article
A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease
With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) and the publication of the metabolic dysfunction-associated fatty liver disease (MAFLD) nomenclature in 2020...
-
Article
Open AccessHigh prevalence of exon-13 variants in USH2A-related retinal dystrophies in Taiwanese population
Biallelic pathogenic variants in USH2A lead to Usher syndrome or non-syndromic retinitis pigmentosa, and shown to have geographical and ethnical distribution in previous studies. This study provided a deeper unde...
-
Article
Open AccessDUSP22 inhibits lung tumorigenesis by suppression of EGFR/c-Met signaling
DUSP22, an atypical dual-specificity phosphatase enzyme, plays a significant role in regulating multiple kinase signaling pathways by dephosphorylation. Our study demonstrated that decreased DUSP22 expression ...
-
Article
Development of accumulative roll bonding for metallic composite material preparation and mechanical/functional applications
Accumulative roll bonding (ARB) is a severe plastic deformation method to prepare the metallic composite material by physical method at room to elevate temperature, without the generation of additional waste s...
-
Article
Achieving high power factor in GaSb with intrinsically high mobility via Ge do**
The thermoelectric power factor is as crucial as their overall thermoelectric performance. GaSb-based compounds are deemed to achieve high power factor owing to their intrinsically high mobility compared to cl...
-
Article
Open AccessCombined associations of visceral adipose tissue and adherence to a Mediterranean lifestyle with T2D and diabetic microvascular complications among individuals with prediabetes
It’s unclear if excess visceral adipose tissue (VAT) mass in individuals with prediabetes can be countered by adherence to a Mediterranean lifestyle (MEDLIFE). We aimed to examine VAT mass, MEDLIFE adherence, ...
-
Article
Correction: Nomogram based on pretreatment hepatic and renal function indicators for survival prediction of locally advanced esophageal squamous cell carcinoma with treatment of neoadjuvant chemoradiotherapy plus surgery
-
Article
Open AccessPOEMS syndrome with undetectable M-protein: a case report and literature review
Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is a rare plasma cell (PC) neoplasm with associated paraneoplastic syndrome. According to the current diagnostic crite...
-
Article
A high-density microfluidic bioreactor for the automated manufacturing of CAR T cells
The manufacturing of autologous chimaeric antigen receptor (CAR) T cells largely relies either on fed-batch and manual processes that often lack environmental monitoring and control or on bioreactors that cann...
-
Article
Open AccessCreatine and l-carnitine attenuate muscular laminopathy in the LMNA mutation transgenic zebrafish
Lamin A/C gene (LMNA) mutations contribute to severe striated muscle laminopathies, affecting cardiac and skeletal muscles, with limited treatment options. In this study, we delve into the investigations of five ...
-
Article
Open AccessGasdermin D deficiency aborts myeloid calcium influx to drive granulopoiesis in lupus nephritis
Gasdermin D (GSDMD) is emerging as an important player in autoimmune diseases, but its exact role in lupus nephritis (LN) remains controversial. Here, we identified markedly elevated GSDMD in human and mouse L...
-
Article
Moving window incremental multidimensional scale analysis-based operational modal analysis for linear slow time varying structure
In order to solve the problems of low precision and high time cost in operational modal analysis for linear slow time-varying (LSTV) structures, a moving window incremental multidimensional scale analysis (MWI...
