26 Result(s)
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Article
Open AccessExtraordinary expansion of a Sorangium cellulosum genome from an alkaline milieu
Complex environmental conditions can significantly affect bacterial genome size by unknown mechanisms. The So0157-2 strain of Sorangium cellulosum is an alkaline-adaptive epothilone producer that grows across a w...
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Open AccessInterferon regulatory factor 9 is critical for neointima formation following vascular injury
Interferon regulatory factor 9 (IRF9) has various biological functions and regulates cell survival; however, its role in vascular biology has not been explored. Here we demonstrate a critical role for IRF9 in ...
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Article
Open AccessCantharidin represses invasion of pancreatic cancer cells through accelerated degradation of MMP2 mRNA
Cantharidin is an active constituent of mylabris, a traditional Chinese medicine and is a potent and selective inhibitor of protein phosphatase 2A (PP2A) that plays an important role in cell cycle control, apo...
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Open AccessCharacterization of the promoter region of the bovine long-chain acyl-CoA synthetase 1 gene: Roles of E2F1, Sp1, KLF15 and E2F4
The nutritional value and eating qualities of beef are enhanced when the unsaturated fatty acid content of fat is increased. Long-chain acyl-CoA synthetase 1 (ACSL1) plays key roles in fatty acid transport and...
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Open AccessRed emission fluorescent probes for visualization of monoamine oxidase in living cells
Here we report two novel red emission fluorescent probes for the highly sensitive and selective detection of monoamine oxidase (MAO) with large Stokes shift (227 nm). Both of the probes possess solid state flu...
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Open AccessForced co-expression of IL-21 and IL-7 in whole-cell cancer vaccines promotes antitumor immunity
Genetic modification of whole-cell cancer vaccines to augment their efficacies has a history of over two and a half decades. Various genes and gene combinations, targeting different aspects of immune responses...
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Open AccessAn optimized transit peptide for effective targeting of diverse foreign proteins into chloroplasts in rice
Various chloroplast transit peptides (CTP) have been used to successfully target some foreign proteins into chloroplasts, but for other proteins these same CTPs have reduced localization efficiencies or fail c...
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Open AccessChronic Intermittent Hypobaric Hypoxia Improves Cardiac Function through Inhibition of Endoplasmic Reticulum Stress
We investigated the role of endoplasmic reticulum stress (ERS) in chronic intermittent hypobaric hypoxia (CIHH)-induced cardiac protection. Adult male Sprague-Dawley rats were exposed to CIHH treatment simulat...
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Article
Open AccessMouse strain differences in SSRI sensitivity correlate with serotonin transporter binding and function
Selective serotonin reuptake inhibitors (SSRIs) bind 5-HT transporters, leading to the accumulation of 5-HT and amelioration of depression. Although different mouse strains show varying sensitivity to SSRIs in...
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Open AccessIGF-1-mediated PKM2/β-catenin/miR-152 regulatory circuit in breast cancer
Dysregulation of miRNAs is important in breast cancer initiation and malignant progression. Recently we showed that miR-152 downregulation is associated with breast cancer development, yet the underlying mecha...
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Open AccessMedial preoptic area in mice is capable of mediating sexually dimorphic behaviors regardless of gender
The medial preoptic area (mPOA) differs between males and females in nearly all species examined to date, including humans. Here, using fiber photometry recordings of Ca2+ transients in freely behaving mice, we s...
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Open AccessPrecise control of SCRaMbLE in synthetic haploid and diploid yeast
Compatibility between host cells and heterologous pathways is a challenge for constructing organisms with high productivity or gain of function. Designer yeast cells incorporating the Synthetic Chromosome Rear...
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Open AccessAuthor Correction: Precise control of SCRaMbLE in synthetic haploid and diploid yeast
The original version of this Article omitted a declaration from the Competing Interests statement, which should have included the following: ‘J.D.B. is a founder and Director of the following: Neochromosome, I...
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Article
Open AccessOptimized pupal age of Tenebrio molitor L. (Coleoptera: Tenebrionidae) enhanced mass rearing efficiency of Chouioia cunea Yang (Hymenoptera: Eulophidae)
Chouioia cunea Yang (Hymenoptera: Eulophidae) has been widely used for biological control of the fall webworm, Hyphantria cunea (Drury) (Lepidoptera: Arctiidae), in China. The yellow mealworm, Tenebrio molitor L....
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Open AccessSystematic analysis reveals the prevalence and principles of bypassable gene essentiality
Gene essentiality is a variable phenotypic trait, but to what extent and how essential genes can become dispensable for viability remain unclear. Here, we investigate ‘bypass of essentiality (BOE)’ — an undere...
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Article
Open AccessA ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours
Accumulating evidence indicates that the zinc-finger transcription factor ZEB1 is predominantly expressed in the stroma of several tumours. However, the role of stromal ZEB1 in tumour progression remains unexp...
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Open AccessReversible thermal regulation for bifunctional dynamic control of gene expression in Escherichia coli
Genetically programmed circuits allowing bifunctional dynamic regulation of enzyme expression have far-reaching significances for various bio-manufactural purposes. However, building a bio-switch with a post l...
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Open AccessProfiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth
Numerous substrates have been identified for Type I and II arginine methyltransferases (PRMTs). However, the full substrate spectrum of the only type III PRMT, PRMT7, and its connection to type I and II PRMT s...
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Open AccessThree chromosome-level duck genome assemblies provide insights into genomic variation during domestication
Domestic ducks are raised for meat, eggs and feather down, and almost all varieties are descended from the Mallard (Anas platyrhynchos). Here, we report chromosome-level high-quality genome assemblies for meat...
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Open AccessAnthrahydroquinone-2-6-disulfonate is a novel, powerful antidote for paraquat poisoning
Paraquat (PQ) is a widely used fast-acting pyridine herbicide. Accidental ingestion or self-administration via various routes can cause severe organ damage. Currently, no effective antidote is available commer...
