105 Result(s)
within
**ao-liang Wang
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessLandform and lithospheric development contribute to the assembly of mountain floras in China
Although it is well documented that mountains tend to exhibit high biodiversity, how geological processes affect the assemblage of montane floras is a matter of ongoing research. Here, we explore landform-spec...
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Open AccessHemodynamic parameters and diabetes mellitus in community-dwelling middle-aged adults and elders: a community-based study
Hemodynamic parameters have been correlated with stroke, hypertension, and arterial stenosis. While only a few small studies have examined the link between hemodynamics and diabetes mellitus (DM). This case-co...
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Open AccessVitrification-enabled enhancement of proton conductivity in hydrogen-bonded organic frameworks
Hydrogen-bonded organic frameworks (HOFs) are versatile materials with potential applications in proton conduction. Traditional approaches involve incorporating humidity control to address grain boundary chall...
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Article
Open AccessGenetic drivers of heterogeneity in type 2 diabetes pathophysiology
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic c...
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Open AccessThe association between alcohol, betel nut, and cigarette use with hepatitis C virus infection in Taiwan
Hepatitis C virus (HCV) infection may cause chronic liver disease, liver cirrhosis, and liver cancer. It has been reported to associate with habits including alcohol, betel nut and cigarette use. We aimed to i...
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Open AccessStabilizing ruthenium dioxide with cation-anchored sulfate for durable oxygen evolution in proton-exchange membrane water electrolyzers
Ruthenium dioxide is the most promising alternative to the prevailing but expensive iridium-based catalysts for the oxygen evolution reaction in proton-exchange membrane water electrolyzers. However, the under...
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Open AccessBoth people living in the COVID-19 epicenter and those who have recently left are at a higher risk of loneliness
There is little empirical data on the heightened risk of loneliness among individuals residing in the COVID-19 epicenter or those who have recently left. This study compared the risk of loneliness in individua...
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Open AccessIGSF6 is a novel biomarker to evaluate immune infiltration in mismatch repair-proficient colorectal cancer
Immunotherapy has dramatically changed the landscape of treatment for colorectal cancer (CRC), but currently lack of effective predictive biomarker, especially for tumors with mismatch repair (MMR) proficiency...
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Open AccessBacterial genome size and gene functional diversity negatively correlate with taxonomic diversity along a pH gradient
Bacterial gene repertoires reflect adaptive strategies, contribute to ecosystem functioning and are limited by genome size. However, gene functional diversity does not necessarily correlate with taxonomic dive...
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Open AccessA route to metalloligands consolidated silver nanoclusters by grafting thiacalix[4]arene onto polyoxovanadates
Metalloligands provide a potent strategy for manipulating the surface metal arrangements of metal nanoclusters, but their synthesis and subsequent installation onto metal nanoclusters remains a significant cha...
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Open AccessA glutamatergic DRN–VTA pathway modulates neuropathic pain and comorbid anhedonia-like behavior in mice
Chronic pain causes both physical suffering and comorbid mental symptoms such as anhedonia. However, the neural circuits and molecular mechanisms underlying these maladaptive behaviors remain elusive. Here usi...
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Open AccessIndividual bat virome analysis reveals co-infection and spillover among bats and virus zoonotic potential
Bats are reservoir hosts for many zoonotic viruses. Despite this, relatively little is known about the diversity and abundance of viruses within individual bats, and hence the frequency of virus co-infection a...
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Enantioconvergent Cu-catalysed N-alkylation of aliphatic amines
Chiral amines are commonly used in the pharmaceutical and agrochemical industries1. The strong demand for unnatural chiral amines has driven the development of catalytic asymmetric methods1,2. Although the N-alky...
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Open AccessMesoporous Pt@Pt-skin Pt3Ni core-shell framework nanowire electrocatalyst for efficient oxygen reduction
The design of Pt-based nanoarchitectures with controllable compositions and morphologies is necessary to enhance their electrocatalytic activity. Herein, we report a rational design and synthesis of anisotropi...
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Open AccessCENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis I
Chromosome segregation is initiated by cohesin degradation, which is driven by anaphase-promoting complex/cyclosome (APC/C). Chromosome cohesin is removed by activated separase, with the degradation of securin...
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Open AccessThermal management of chips by a device prototype using synergistic effects of 3-D heat-conductive network and electrocaloric refrigeration
With speeding up development of 5 G chips, high-efficient thermal structure and precise management of tremendous heat becomes a substantial challenge to the power-hungry electronics. Here, we demonstrate an in...
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Open AccessUltrasound-assessed diaphragm dysfunction predicts clinical outcomes in hemodialysis patients
Skeletal muscle atrophy is prevalent and remarkably increases the risk of cardiovascular (CV) events and mortality in hemodialysis (HD) patients. However, whether diaphragm dysfunction predicts clinical outcom...
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Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion
High cholesterol is a major risk factor for cardiovascular disease1. Currently, no drug lowers cholesterol through directly promoting cholesterol excretion. Human genetic studies have identified that the loss-of-...
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Open AccessRoom-temperature dynamic nuclear polarization enhanced NMR spectroscopy of small biological molecules in water
Nuclear magnetic resonance (NMR) spectroscopy is a powerful and popular technique for probing the molecular structures, dynamics and chemical properties. However the conventional NMR spectroscopy is bottleneck...
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Open AccessSelective and predicable amine conjugation sites by kinetic characterization under excess reagents
The site selectivity for lysine conjugation on a native protein is difficult to control and characterize. Here, we applied mass spectrometry to examine the conjugation kinetics of Trastuzumab-IgG (Her-IgG) and...
