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    Manganese regulation of COPII condensation controls circulating lipid homeostasis

    Precise control of circulating lipids is instrumental in health and disease. Bulk lipids, carried by specialized lipoproteins, are secreted into the circulation, initially via the coat protein complex II (COPI...

    **ao Wang, Runze Huang, Yawei Wang, Wen**g Zhou, Yating Hu in Nature Cell Biology (2023)

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    PTENα and PTENβ promote carcinogenesis through WDR5 and H3K4 trimethylation

    PTENα and PTENβ are two longer translational variants of phosphatase and tensin homolog (PTEN) messenger RNA. Their expressional regulations and functions in carcinogenesis remain largely unknown. Here, we dem...

    Shao-Ming Shen, Cheng Zhang, Meng-Kai Ge, Shuang-Shu Dong, Li **a in Nature Cell Biology (2019)

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    Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer

    The zinc-finger transcription factor Snail1 is inappropriately expressed in breast cancer and associated with poor prognosis. While interrogating human databases, we uncovered marked decreases in relapse-free ...

    Ting Ni, **ao-Yan Li, Na Lu, Teng An, Zhi-** Liu, Rong Fu in Nature Cell Biology (2016)