62 Result(s)

Article

Mycophenolic acid inhibits SLE-associated cytokine expression and promotes apoptosis of peripheral blood mononuclear cells from patients with systemic lupus erythematosus

To investigate the effect of the novel immunosuppressant mycophenolic acid (MPA) on cytokine production and apoptosis of the peripheral blood mono-nuclear cells (PBMC) of patients with systemic lupus erythemat...

Ding-lei Su, Hui-juan Wang, **ao-hui Ji, Yuan-yuan Li… in Acta Pharmacologica Sinica (2006)

Article

Dehydroevodiamine attenuates calyculin A-induced tau hyperphos-phorylation in rat brain slices

This study was to investigate the effect of dehydroevodiamine (DHED) on Alzheimer's disease (AD)-like tau hyperphosphorylation induced by calyculin A (CA), an inhibitor of protein phosphatase (PP)-2A and PP-1,...

Jiang Fang, Rong Liu, Qing Tian, ** Hong… in Acta Pharmacologica Sinica (2007)

Article

Rosiglitazone sensitizes hepatocellular carcinoma cell lines to 5-fluorouracil antitumor activity through activation of the PPARγ signaling pathway

Resistance to 5-fluorouracil (5-FU) is a major cause of chemotherapy failure in advanced hepatocellular carcinoma (HCC).Rosiglitazone, a peroxisome proliferator-activated receptor γ (PPARγ) agonist, has a cruc...

Liang-qi Cao, **ao-li Wang, Qian Wang, ** Xue… in Acta Pharmacologica Sinica (2009)

Article

Prenatal exposure to lipopolysaccharide alters the intrarenal renin–angiotensin system and renal damage in offspring rats

Prenatal exposure to inflammation produces offspring that are hypertensive in adulthood. This study explored alterations of the renin–angiotensin system (RAS) during the development of hypertension induced by ...

Xue-Qin Hao, Hai-Gang Zhang, Zhi-Bing Yuan, Dan-Li Yang… in Hypertension Research (2010)

Article

The important roles of RET, VEGFR2 and the RAF/MEK/ERK pathway in cancer treatment with sorafenib

To elucidate the roles of receptor tyrosine kinases RET and VEGFR2 and the RAF/MEK/ERK signaling cascade in cancer treatment with sorafenib.

Wei-feng Mao, Min-hua Shao, Pin-ting Gao, Ji Ma, Hui-juan Li… in Acta Pharmacologica Sinica (2012)

Article

Comparative pharmacokinetics of cefuroxime lysine after single intravenous, intraperitoneal, and intramuscular administration to rats

To compare the pharmacokinetic parameters of cefuroxime lysine, a new second-generation of cephalosporin antibiotics, after intravenous (IV), intraperitoneal (IP), or intramuscular (IM) administration.

Long-shan Zhao, Ran Yin, Bin-bin Wei, Qing Li… in Acta Pharmacologica Sinica (2012)

Article

Lanthanum carbonate for the treatment of hyperphosphatemia in CKD 5D: multicenter, double blind, randomized, controlled trial in mainland China

Serum phosphorus control is critical for chronic kidney disease (CKD) 5D patients. Currently, clinical profile for an oral phosphorus binder in the mainland Chinese population is not available.

**g Xu, Yi-**ang Zhang, Xue-Qing Yu, Zhi-Hong Liu, Li-Ning Wang… in BMC Nephrology (2013)

Article

Mycophenolic acid derivative 118 improves outcome of skin grafts by suppressing IL-17 production

To investigate the effects and underlying mechanisms of 118, a novel derivative of mycophenolic acid, in a murine allogeneic skin graft model.

Fang-yuan Kong, Wei Chen, Shi-jun He, Ze-min Lin, … in Acta Pharmacologica Sinica (2013)

Article

Bornyl caffeate induces apoptosis in human breast cancer MCF-7 cells via the ROS- and JNK-mediated pathways

To investigate the effects of bornyl caffeate discovered in several species of plant on human breast cancer cells in vitro and the underlying mechanisms.

Chuan-bin Yang, Wei-**g Pei, Jia Zhao, Yuan-yuan Cheng… in Acta Pharmacologica Sinica (2014)

Article

Epidemiologic characterization of 30 confirmed cases of human infection with avian influenza A(H7N9) virus in Hangzhou, China

We examined the clinical and epidemiological characteristics of 30 cases of human infection with avian influenza A(H7N9) virus in Hangzhou and investigated their external environments to provide evidence for c...

Hua Ding, Li **e, Zhou Sun, Qing-Jun Kao, Ren-Jie Huang… in BMC Infectious Diseases (2014)

Article

Identification of anti-inflammatory fractions of Geranium wilfordii using tumor necrosis factor-alpha as a drug target on Herbochip® – an array-based high throughput screening platform

Geranium wilfordii is one of the major species used as Herba Geranii (lao-guan-cao) in China, it is commonly used solely or in polyherbal formulations for treatment of joint pain resulted from rheumatoid arthriti...

Min Huang, Pei-Wun Yao… in BMC Complementary and Alternative Medicine (2015)

Article

Features of COPD patients by comparing CAT with mMRC: a retrospective, cross-sectional study

The group assignment of chronic obstructive pulmonary disease (COPD) may differ depending on whether the COPD assessment test (CAT) or modified Medical Research Council dyspnoea scale (mMRC) is used.

Wei-Chang Huang, Ming-Feng Wu, Hui-Chen Chen… in npj Primary Care Respiratory Medicine (2015)

Article

Validation of a new simple scale to measure symptoms in heart failure from traditional Chinese medicine view: a cross-sectional questionnaire study

Current clinical practices used to functionally classify heart failure (HF) are time-consuming, expensive, or require complex calculations. This study aimed to design an inquiry list from the perspective of tr...

Tieh-Cheng Fu, Yi-Chung Lin, Ching-Mao Chang… in BMC Complementary and Alternative Medicine (2016)

Article

World Congress Integrative Medicine & Health 2017: part two

Carolyn Ee, Sharmala Thuraisingam… in BMC Complementary and Alternative Medicine (2017)