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Article
Open AccessEstablishment of an ovarian cancer exhausted CD8+T cells-related genes model by integrated analysis of scRNA-seq and bulk RNA-seq
Ovarian cancer (OC) was the fifth leading cause of cancer death and the deadliest gynecological cancer in women. This was largely attributed to its late diagnosis, high therapeutic resistance, and a dearth of ...
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Article
Side-Chain-Type Polyimide-Cu Complexes with Suppressed Activation Energy of Relaxation for Advanced High-Temperature Capacitor
The burgeoning growth of the new energy vehicles and aviation industry has escalated the need for energy storage capacitors capable of stable operation in harsh environments. The advent of metal-polyimide comp...
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Article
Open AccessThe rise of baobab trees in Madagascar
The baobab trees (genus Adansonia) have attracted tremendous attention because of their striking shape and distinctive relationships with fauna1. These spectacular trees have also influenced human culture, inspir...
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Article
Open AccessShort-chain fatty acid-producing bacterial strains attenuate experimental ulcerative colitis by promoting M2 macrophage polarization via JAK/STAT3/FOXO3 axis inactivation
Patients with inflammatory bowel disease (IBD), dysbiosis, and immunosuppression who receive fecal microbiota transplantation (FMT) from healthy donors are at an increased risk of develo** bacteremia. This s...
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Article
γ-Radiation Induced Deposition of Au Nanoparticles on Defect-Rich CdS for Enhanced CO2 Photoreduction Under Visible Light
Photoreduction of CO2 into high-value chemicals is one of the promising strategies to mitigate CO2 emission and alleviate energy challenges, while the design and development of high-performance photocatalysts are...
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Article
NνDEx-100 conceptual design report
Observing nuclear neutrinoless double beta (0 \(\nu \beta \beta\) ν ...
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Article
A review of the effect of tungsten alloying on the microstructure and properties of steels
With the continuous development of science and technology, the increasingly severe service environment makes people put forward higher requirements for the performance of alloy steel. Tungsten has unique prope...
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Article
Open AccessCorrection: CircSMARCC1 facilitates tumor progression by disrupting the crosstalk between prostate cancer cells and tumor-associated macrophages via miR-1322/CCL20/CCR6 signaling
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Article
An iterative blending integrating grinding force model considering grain size and dislocation density evolution
The dynamic force load in grinding process is considered as a crucial factor affecting the quality of parts, and a better understanding of the mechanism of force generation is conducive to revealing the evolut...
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Article
Generation of genuine entanglement up to 51 superconducting qubits
Scalable generation of genuine multipartite entanglement with an increasing number of qubits is important for both fundamental interest and practical use in quantum-information technologies1,2. On the one hand, m...
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Article
Open AccessMetavirome of 31 tick species provides a compendium of 1,801 RNA virus genomes
The increasing prevalence and expanding distribution of tick-borne viruses globally have raised health concerns, but the full repertoire of the tick virome has not been assessed. We sequenced the meta-transcri...
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Article
Open AccessLoss of function of CMPK2 causes mitochondria deficiency and brain calcification
Brain calcification is a critical aging-associated pathology and can cause multifaceted neurological symptoms. Cerebral phosphate homeostasis dysregulation, blood-brain barrier defects, and immune dysregulatio...
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Article
Open AccessCircSMARCC1 facilitates tumor progression by disrupting the crosstalk between prostate cancer cells and tumor-associated macrophages via miR-1322/CCL20/CCR6 signaling
Circular RNAs (circRNAs) mediate the infiltration of tumor-associated macrophages (TAMs) to facilitate carcinogenesis and development of various types of cancers. However, the role of circRNAs in regulating ma...
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Article
Catalyst particle shapes and pore structure engineering for hydrodesulfurization and hydrodenitrogenation reactions
Catalyst particle shapes and pore structure engineering are crucial for alleviating internal diffusion limitations in the hydrodesulfurization (HDS)/hydrodenitrogenation (HDN) of gas oil. The effects of cataly...
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Article
Open AccessReconstructed covalent organic frameworks
Covalent organic frameworks (COFs) are distinguished from other organic polymers by their crystallinity1–3, but it remains challenging to obtain robust, highly crystalline COFs because the framework-forming react...
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Article
Open AccessRestoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing
The age-dependent decline in remyelination potential of the central nervous system during ageing is associated with a declined differentiation capacity of oligodendrocyte progenitor cells (OPCs). The molecular...
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Article
Highly efficient nanocatalyst Ni1Co9@graphene for hydrolytic dehydrogenation of sodium borohydride
Bimetal materials derived from transition metals can be good catalyst candidates towards some specific reactions. When loaded on graphene (GP), these catalysts exhibit remarkable performance in the hydrolysis ...
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Article
Open AccessYinQiSanHuang Jiedu decoction for the treatment of hepatitis B-related compensated liver cirrhosis: study protocol for a multi-center randomized controlled trial
Hepatitis B-related compensated liver cirrhosis is related to a higher risk of hepatocellular carcinoma, and antiviral therapy is the preferred method. As the pathological mechanisms of liver fibrosis are comp...
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Article
Prognostic potential of layer-specific global longitudinal strain in patients with non-ST-segment elevated acute coronary syndrome and preserved left ventricular ejection fraction
This study sought to investigate the prognostic potential of layer-specific global longitudinal strain (GLS) in predicting cardiac events among non-ST-segment elevated acute coronary syndrome (NSTE-ACS) patien...
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Article
Open AccessSerum lnc34a is a potential prediction biomarker for bone metastasis in hepatocellular carcinoma patients
Early screening and intervention therapies are crucial to improve the prognosis of hepatocellular carcinoma (HCC) patients with bone metastasis. We aimed to identify serum lncRNA as a prediction biomarker in H...
