7 Result(s)

Article

Author Correction: Darinaparsin (ZIO-101) enhances the sensitivity of small-cell lung cancer to PARP inhibitors

Guo-zhen Cao, Li-ying Ma, Zong-hui Zhang, **ao-lin Wang… in Acta Pharmacologica Sinica (2023)

Article

Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma

HDAC inhibitors (HDACis) have been intensively studied for their roles and potential as drug targets in T-cell lymphomas and other hematologic malignancies. Bisthianostat is a novel bisthiazole-based pan-HDACi...

Yu-bo Zhou, Yang-ming Zhang, Hong-hui Huang, Li-**g Shen… in Acta Pharmacologica Sinica (2022)

Article

In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubine

Berberrubine (BRB) is the primary metabolite of berberine (BBR) that has shown a stronger glucose-lowering effect than BBR in vivo. On the other hand, BRB is quickly and extensively metabolized into berberrubine-...

Na Yang, Run-bin Sun, **ng-long Chen, Le Zhen, Chun Ge… in Acta Pharmacologica Sinica (2017)

Article

Biochemical features of the adhesion G protein-coupled receptor CD97 related to its auto-proteolysis and HeLa cell attachment activities

CD97 belongs to the adhesion GPCR family characterized by a long ECD linked to the 7TM via a GPCR proteolytic site (GPS) and plays important roles in modulating cell migration and invasion. CD97 (EGF1-5) is a ...

Li-yun Yang, **ao-fang Liu, Yang Yang, Lin-lin Yang… in Acta Pharmacologica Sinica (2017)

Article

Strontium ranelate reduces cartilage degeneration and subchondral bone remodeling in rat osteoarthritis model

To investigate whether strontium ranelate (SR), a new antiosteoporotic agent, could attenuate cartilage degeneration and subchondral bone remodeling in osteoarthritis (OA).

De-gang Yu, Hui-feng Ding, Yuan-qing Mao, Ming Liu, Bo Yu… in Acta Pharmacologica Sinica (2013)

Article

Pharmacokinetic interactions induced by content variation of major water-soluble components of Danshen preparation in rats

To investigate the pharmacokinetic interactions induced by content variation of the main water-soluble components of Danshen injection in rats.

Bo-bo Chang, Lin Zhang, Wan-wen Cao, Yuan Cao, Wen-liang Yang… in Acta Pharmacologica Sinica (2010)

Article

L-carnitine and taurine synergistically inhibit the proliferation and osteoblastic differentiation of vascular smooth muscle cells

To investigate the synergistic action of L-carnitine (LC) and taurine (TAU) on the proliferation and osteoblastic differentiation of vascular smooth muscle cells (VSMCs).

Hui **e, Bing Yang, **n-min Zhou, Feng-lin Song, Jian-ming Li… in Acta Pharmacologica Sinica (2010)