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Article
Development and Validation of a Prognostic Model for Postoperative Anastomotic Recurrence in Siewert II or III Adenocarcinomas Without Neoadjuvant Therapy in an East Asian Population
Anastomotic recurrence leads to poor prognosis in patients with Siewert II or III adenocarcinoma who undergo radical gastrectomy and do not receive neoadjuvant therapy. We aimed to establish a prognostic model...
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Article
Open AccessMetabolic landscape and pathogenic insights: a comprehensive analysis of high ovarian response in infertile women undergoing in vitro fertilization
In the realm of assisted reproduction, a subset of infertile patients demonstrates high ovarian response following controlled ovarian stimulation (COS), with approximately 29.7% facing the risk of Ovarian Hype...
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Article
High critical current density in Li6.4La3Zr1.4Ta0.6O12 electrolyte via interfacial engineering with complex hydride
Garnet-type solid-state batteries (SSBs) are considered to be one of the most promising candidates to realize next-generation lithium metal batteries with high energy density and safety. However, the dendrite-...
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Article
Open AccessRadiomic signatures reveal multiscale intratumor heterogeneity associated with tissue tolerance and survival in re-irradiated nasopharyngeal carcinoma: a multicenter study
Post-radiation nasopharyngeal necrosis (PRNN) is a severe adverse event following re-radiotherapy for patients with locally recurrent nasopharyngeal carcinoma (LRNPC) and associated with decreased survival. Bi...
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Article
Ca2+ Regulates Autophagy Through CaMKKβ/AMPK/mTOR Signaling Pathway in Mechanical Spinal cord Injury: An in vitro Study
Spinal cord injury (SCI), resulting in damage of the normal structure and function of the spinal cord, would do great harm to patients, physically and psychologically. The mechanism of SCI is very complex. At ...
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Article
Open AccessStabilization of SAMHD1 by NONO is crucial for Ara-C resistance in AML
Cytarabine (Ara-C) is the first-line drug for the treatment of acute myelogenous leukemia (AML). However, resistance eventually develops, decreasing the efficacy of Ara-C in AML patients. The expression of SAM...
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Article
Open AccessThe synergistic anticancer effect of the bromodomain inhibitor OTX015 and histone deacetylase 6 inhibitor WT-161 in osteosarcoma
Osteosarcoma (OS) is a tumour with a high malignancy level and a poor prognosis. First-line chemotherapy for OS has not been improved for many decades. Bromodomain and extraterminal domain (BET) and histone de...
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Article
Tight junction protein 1 promotes vasculature remodeling via regulating USP2/TWIST1 in bladder cancer
Bladder cancer (BLCA) is the most common malignant tumor of the urinary system and is characterized by high metastatic rates and poor prognosis. The expression of tight junction protein 1 (TJP1) is associated ...
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Article
Open AccessLong non-coding RNA NORAD promotes pancreatic cancer stem cell proliferation and self-renewal by blocking microRNA-202-5p-mediated ANP32E inhibition
Cancer stem cells (CSCs) are key regulators in the processes of tumor initiation, progression, and recurrence. The mechanism that maintains their stemness remains enigmatic, although the role of several long n...
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Article
Open AccessmiR-4293 upregulates lncRNA WFDC21P by suppressing mRNA-decap** enzyme 2 to promote lung carcinoma proliferation
Non-coding RNAs (ncRNAs) involve in diverse biological processes by post-transcriptional regulation of gene expression. Emerging evidence shows that miRNA-4293 plays a significant role in the development of no...
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Article
Targeting the p300/NONO axis sensitizes melanoma cells to BRAF inhibitors
BRAF inhibitors (BRAFi) that target BRAF V600E kinase, a driver mutation found in 50% of melanomas, show a significant antitumor response, but the common emergence of acquired resistance remains a challenge. A...
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Article
Open AccessRole of LncRNAs in regulating cancer amino acid metabolism
The metabolic change of tumor cells is an extremely complicated process that involves the intersection and integration of various signal pathways. Compared with normal tissues, cancer cells show distinguished ...
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Article
Hierarchical Fe3O4@C nanofoams derived from metal–organic frameworks for high-performance lithium storage
A facile method was employed to in situ prepare hierarchical mesoporous Fe3O4@C nanofoams through pyrolysis of a post-treated MIL-53(Fe) precursor. Well-defined carbon network-encapsulated ultrasmall and uniform ...
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Article
Open AccessComparison of haplo-SCT and chemotherapy for young adults with standard-risk Ph-negative acute lymphoblastic leukemia in CR1
Human leukocyte antigen (HLA) haploidentical stem cell transplantation (haplo-SCT) as a postremission treatment for standard risk Philadelphia chromosome-negative acute lymphoblastic leukemia (SR Ph-ALL) in th...
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Article
Open AccessAngiopoietin-2 induces angiogenesis via exosomes in human hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and is a highly vascularized solid tumor. Angiopoietin-2 (ANGPT2) has been described as an attractive target for antiangiogenic therapy. E...
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Article
Macrophage-derived CCL18 promotes osteosarcoma proliferation and migration by upregulating the expression of UCA1
Osteosarcoma (OS), which is the most common primary malignant bone tumor, has a high incidence of pulmonary metastasis. CCL18 (C-C motif chemokine ligand 18), which is secreted by tumor-associated macrophages ...
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Article
Reduced hsa-miR-124-3p levels are associated with the poor survival of patients with hepatocellular carcinoma
Hsa-MicroRNA-124a-3p (hsa-miR-124-3p) is involved in tumor progression in certain malignant tumors. However, its function and clinical implication in hepatocellular carcinoma (HCC) have not yet been illustrate...
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Article
Open AccessLncRNA SNHG5 promotes the progression of osteosarcoma by sponging the miR-212-3p/SGK3 axis
Long non-coding RNA (lncRNA) SNHG5 has been found to play an important role in tumors. Nevertheless, the function and mechanism of lncRNA SNHG5 in osteosarcoma (OS) remains unclear. The purpose of this study w...
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Article
Corrosion and passive behaviour of duplex stainless steel 2205 at different cooling rates in a simulated marine-environment solution
The corrosion and passive behaviour of duplex stainless steel 2205 at six cooling rates (1, 5, 10, 15, 20 °C s−1 and water quenched) in a simulated marine-environment solution was investigated using electrochemic...
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Article
Open AccessThe decade of exosomal long RNA species: an emerging cancer antagonist
Exosomes have emerged as a novel approach for the treatment and diagnosis of cancer after RNA content was discovered in exosomes in 2007. As important meditators of intercellular communication, exosomes have b...
